Search Results - "Matulis, D"

Synthesis and histone deacetylases inhibitory activity of pyrimidine‐based 1,3,4‐oxadiazoles by Jakubkiene, V., Labalaukyte, I., Schweipert, M., Zubriene, A., Meyer‐Almes, F.‐J., Matulis, D., Tumkevicius, S.

“…The histone deacetylases (HDACs) are being explored as a promising therapeutic target for the treatment of various diseases. Here, the synthesis of a series of…”
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A combinatorial biophysical approach; FTSA and SPR for identifying small molecule ligands and PAINs by Redhead, M., Satchell, R., Morkūnaitė, V., Swift, D., Petrauskas, V., Golding, E., Onions, S., Matulis, D., Unitt, J.

“…Biophysical methods have emerged as attractive screening techniques in drug discovery both as primary hit finding methodologies, as in the case of weakly…”
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Synthesis of a new heterocyclic system: 3-phenylbenzimidazo[1,2-c]-[1,2,3]selenadiazole by Labanauskas, L, Dudutiene, V, Matulis, D, Urbelis, G

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High-dose therapy and autologous stem cell transplant does not result in long-term disease-free survival in patients with recurrent chemotherapy-sensitive ALK-negative anaplastic large-cell lymphoma by ZAMKOFF, K. W, MATULIS, M. D, MEHTA, A. C, BEATY, M. W, HUTCHISON, R. E, GENTILE, T. C

“…Primary systemic anaplastic lymphoma kinase (ALK)-negative anaplastic large-cell lymphoma (ALCL) has a poor prognosis. This study sought to determine if…”
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Simplified assay for VWF cleaving protease (ADAMTS13) activity and inhibitor in plasma by Knovich, Mary Ann, Craver, Karen, Matulis, Melissa D., Lawson, Heather, Owen, John

“…The absence of VWF cleaving protease activity (VWFcp, ADAMTS13) has recently been identified as a central component in the pathogenesis of TTP. Several assays…”
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Thermodynamic Stability of Carbonic Anhydrase:  Measurements of Binding Affinity and Stoichiometry Using ThermoFluor by Matulis, Daumantas, Kranz, James K, Salemme, F. Raymond, Todd, Matthew J

“…ThermoFluor (a miniaturized high-throughput protein stability assay) was used to analyze the linkage between protein thermal stability and ligand binding…”
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Protein–Ligand Binding Database (PLBD) of crystal structures and intrinsic thermodynamic parameters by Lingė, D., Gedgaudas, M., Merkys, A., Petrauskas, V., Vaitkus, A., Grybauskas, A., Paketurytė, V., Zubrienė, A., Zakšauskas, A., Mickevičiūtė, A., Smirnovienė, J., Baranauskienė, L., Čapkauskaitė, E., Dudutienė, V., Urniežius, E., Konovalovas, A., Kazlauskas, E., Shubin, K., Schiöth, H. B., Chen, W.-Y., Ladbury, J. E., Gražulis, S., Matulis, D.

“…Abstract only…”
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Selective precipitation of proteins by Lovrien, R E, Matulis, D

“…Selective precipitation of proteins can be used as a bulk method to recover the majority of proteins from a crude lysate, as a selective method to fractionate…”
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Intrinsic vs. observed thermodynamic and kinetic parameters of carbonic anhydrase-ligand interaction by Linkuviene, V., Talibov, Vladimir O., Danielson, U. Helena, Matulis, D.

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Ligand-Protein Coprecipitative Isolation by Matrix Stacking and Entanglement by LOVRIEN, REX, WU, CHARLES, MATULIS, DAUMANTAS

“…Ligands are being developed for the upstream isolation-purification of sought-for proteins from dilute crudes by ligand-protein coprecipitation. The ligands…”
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1-Anilino-8-Naphthalene Sulfonate Anion-Protein Binding Depends Primarily on Ion Pair Formation by Matulis, Daumantas, Lovrien, Rex

“…The ANS − (1-anilino-8-naphthalene sulfonate) anion is strongly, dominantly bound to cationic groups of water-soluble proteins and polyamino acids through ion…”
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Thermodynamics of Cationic Lipid Binding to DNA and DNA Condensation:  Roles of Electrostatics and Hydrophobicity by Matulis, Daumantas, Rouzina, Ioulia, Bloomfield, Victor A

“…Alkylammonium binding to DNA was studied by isothermal titration calorimetry. Experimental data, obtained as functions of alkyl chain length, salt…”
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Thermodynamics of DNA binding and condensation: isothermal titration calorimetry and electrostatic mechanism by Matulis, D, Rouzina, I, Bloomfield, V A

“…The thermodynamics of binding of the trivalent cations cobalt hexammine and spermidine to plasmid DNA was studied by isothermal titration calorimetry. Two…”
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Thermodynamics of the hydrophobic effect. III. Condensation and aggregation of alkanes, alcohols, and alkylamines by Matulis, Daumantas

“…Knowledge of the energetics of the low solubility of non-polar compounds in water is critical for the understanding of such phenomena as protein folding and…”
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1-Anilino-8-naphthalene sulfonate as a protein conformational tightening agent by Matulis, Daumantas, Baumann, Christoph G., Bloomfield, Victor A., Lovrien, Rex E.

“…1‐Anilino‐8‐naphthalene sulfonate (ANS) anion is conventionally considered to bind to preexisting hydrophobic (nonpolar) surfaces of proteins, primarily…”
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Hsp90 stabilizes Cdc25A and counteracts heat shock-mediated Cdc25A degradation and cell-cycle attenuation in pancreatic carcinoma cells by GIESSRIG, Benedikt, KRIEGER, Sigurd, KOPF, Sabine, KAZLAUSKAS, Egidijus, MAZAL, Peter, SZEKERES, Thomas, HENGSTSCHLÄGER, Markus, MATULIS, Daumantas, JÄGER, Walter, KRUPITZA, Georg, ROSNER, Margit, HUTTARY, Nicole, SAIKO, Philipp, ALAMI, Mouad, MESSAOUDI, Samir, PEYRAT, Jean-François, MACIUK, Alexandre, GOLLINGER, Michaela

“…Pancreas cancer cells escape most treatment options. Heat shock protein (Hsp)90 is frequently over-expressed in pancreas carcinomas and protects a number of…”
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Discovery and Validation of SIRT2 Inhibitors Based on Tenovin-6: Use of a 1 H-NMR Method to Assess Deacetylase Activity by Pirrie, L, McCarthy, AR, Major, LL, Morkunaite, V, Zubriene, A, Matulis, D, Lain, S, Lebl, T, Westwood, NJ

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Objects moving on fixed paths location uncertainty in GSM network by Matulis, D.

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Discovery and validation of SIRT2 inhibitors based on tenovin-6: use of a ¹H-NMR method to assess deacetylase activity by Pirrie, Lisa, McCarthy, Anna R, Major, Louise L, Morkūnaitė, Vaida, Zubrienė, Asta, Matulis, Daumantas, Lain, Sonia, Lebl, Tomas, Westwood, Nicholas J

“…The search for potent and selective sirtuin inhibitors continues as chemical tools of this type are of use in helping to assign the function of this…”
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Thermodynamics of Cationic Lipid Binding to DNA and DNA Condensation: Roles of Electrostatics and Hydrophobicity by Matulis, D, Rouzina, I, Bloomfield, V A

“…Alkylammonium binding to DNA was studied by isothermal titration calorimetry. Experimental data, obtained as functions of alkyl chain length, salt…”
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