Search Results - "Mattson, Gail K."

Synthesis and evaluation of carbamate and aryl ether substituted pyrazinones as corticotropin releasing factor-1 (CRF1) receptor antagonists by Ahuja, Vijay T., Hartz, Richard A., Molski, Thaddeus F., Mattson, Gail K., Lentz, Kimberley A., Grace, James E., Lodge, Nicholas J., Bronson, Joanne J., Macor, John E.

“…[Display omitted] A series of pyrazinone-based compounds incorporating either carbamate or aryl ether groups was synthesized and evaluated as…”
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Conformationally Restricted Homotryptamines. Part 7: 3-cis-(3-Aminocyclopentyl)indoles As Potent Selective Serotonin Reuptake Inhibitors by King, H. Dalton, Meng, Zhaoxing, Deskus, Jeffrey A, Sloan, Charles P, Gao, Qi, Beno, Brett R, Kozlowski, Edward S, LaPaglia, Melissa A, Mattson, Gail K, Molski, Thaddeus F, Taber, Matthew T, Lodge, Nicholas J, Mattson, Ronald J, Macor, John E

“…A series of conformationally restricted homotryptamines has been synthesized and shown to be potent inhibitors of hSERT. Conformational restriction of the…”
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[18F](R)-5-chloro-1-(1-cyclopropyl-2-methoxyethyl)-3-(4-(2-fluoroethoxy)-2,5-dimethyl phenylamino)pyrazin-2(1H)-one: Introduction of N3-phenylpyrazinones as potential CRF-R1 PET imaging agents by Deskus, Jeffrey A., Dischino, Douglas D., Mattson, Ronald J., Ditta, Jonathan L., Parker, Michael F., Denhart, Derek J., Zuev, Dmitry, Huang, Hong, Hartz, Richard A., Ahuja, Vijay T., Wong, Henry, Mattson, Gail K., Molski, Thaddeus F., Grace, James E., Zueva, Larisa, Nielsen, Julia M., Dulac, Heidi, Li, Yu-Wen, Guaraldi, Mary, Azure, Michael, Onthank, David, Hayes, Megan, Wexler, Eric, McDonald, Jennifer, Lodge, Nicholas J., Bronson, Joanne J., Macor, John E.

“…Based on a favorable balance between CRF-R1 affinity, lipophilicity and metabolic stability, compound 10 was evaluated for potential development as PET…”
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Conformationally Restricted Homotryptamines. 2. Indole Cyclopropylmethylamines as Selective Serotonin Reuptake Inhibitors by Mattson, Ronald J, Catt, John D, Denhart, Derek J, Deskus, Jeffrey A, Ditta, Jonathan L, Higgins, Mendi A, Marcin, Lawrence R, Sloan, Charles P, Beno, Brett R, Gao, Qi, Cunningham, Melissa A, Mattson, Gail K, Molski, Thaddeus F, Taber, Matthew T, Lodge, Nicholas J

“…A series of indole cyclopropylmethylamines were found to be potent serotonin reuptake inhibitors. Nitrile substituents at the 5 and 7 positions of the indole…”
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Potential CRF1R PET imaging agents: 1-Fluoroalkylsubstituted 5-halo-3-(arylamino)pyrazin-2(1H)-ones by Denhart, Derek J., Zuev, Dmitry, Ditta, Jonathan L., Hartz, Richard A., Ahuja, Vijay T., Mattson, Ronald J., Huang, Hong, Mattson, Gail K., Zueva, Larisa, Nielsen, Julia M., Kozlowski, Edward S., Lodge, Nicholas J., Bronson, Joanne J., Macor, John E.

“…A series of pyrazinones were prepared and evaluated as potential CRF1R PET imaging agents. Optimization of their CRF1R binding potencies and octanol–phosphate…”
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Conformationally restricted homotryptamines. Part 6: Indole-5-cycloalkyl methylamines as selective serotonin reuptake inhibitors by Ditta, Jonathan L., Denhart, Derek J., Deskus, Jeffrey A., Epperson, James R., Meng, Zhaoxing, Gao, Qi, Mattson, Gail K., LaPaglia, Mellissa A., Taber, Matthew T., Molski, Thaddeus F., Lodge, Nicholas J., Mattson, Ronald J., Macor, John E.

“…Racemic 5-(trans-2-aminomethylcyclopropyl)indoles, 5-(trans-2-aminomethylcyclopentyl) indoles, and 5-(cis-2-aminomethylcyclopentyl)indoles were synthesized and…”
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Pharmacological characterization and appetite suppressive properties of BMS-193885, a novel and selective neuropeptide Y1 receptor antagonist by ANTAL-ZIMANYI, Ildiko, BRUCE, Marc. A, ORTIZ, Astrid A, POINDEXTER, Graham S, LEBOULLUEC, Karen L, IBEN, Lawrence G, MATTSON, Gail K, MCGOVERN, Rachel T, HOGAN, John B, LEAHY, Christina L, FLOWERS, Sharon C, STANLEY, Jennifer A

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Synthesis, Structure−Activity Relationships, and In Vivo Evaluation of N 3-Phenylpyrazinones as Novel Corticotropin-Releasing Factor-1 (CRF1) Receptor Antagonists by Hartz, Richard A, Ahuja, Vijay T, Arvanitis, Argyrios G, Rafalski, Maria, Yue, Eddy W, Denhart, Derek J, Schmitz, William D, Ditta, Jonathan L, Deskus, Jeffrey A, Brenner, Allison B, Hobbs, Frank W, Payne, Joseph, Lelas, Snjezana, Li, Yu-Wen, Molski, Thaddeus F, Mattson, Gail K, Peng, Yong, Wong, Harvey, Grace, James E, Lentz, Kimberley A, Qian-Cutrone, Jingfang, Zhuo, Xiaoliang, Shu, Yue-Zhong, Lodge, Nicholas J, Zaczek, Robert, Combs, Andrew P, Olson, Richard E, Bronson, Joanne J, Mattson, Ronald J, Macor, John E

“…Evidence suggests that corticotropin-releasing factor-1 (CRF1) receptor antagonists may offer therapeutic potential for the treatment of diseases associated…”
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Potential CRF1R PET imaging agents: N-Fluoroalkyl-8-(6-methoxy-2-methyl-pyridin-3-yl)-2,7-dimethyl-N-alkylpyrazolo[1,5-a][1,3,5]triazin-4-amines by ZUEV, Dmitry, MATTSON, Ronald J, LODGE, Nicholas J, BRONSON, Joanne J, MACOR, John E, HONG HUANG, MATTSON, Gail K, ZUEVA, Larisa, NIELSEN, Julia M, KOZLOWSKI, Edward S, STELLA HUANG, Xiaohua, DEDONG WU, QI GAO

“…A series of N-fluoroalkyl-8-(6-methoxy-2-methylpyridin-3-yl)-2,7-dimethyl-N-alkylpyrazolo[1,5-a][1,3,5]triazin-4-amines were prepared and evaluated as…”
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Conformationally restricted homotryptamines. Part 5: 3-(trans-2-aminomethylcyclopentyl)indoles as potent selective serotonin reuptake inhibitors by Denhart, Derek J., Deskus, Jeffrey A., Ditta, Jonathan L., Gao, Qi, Dalton King, H., Kozlowski, Edward S., Meng, Zhaoxing, LaPaglia, Melissa A., Mattson, Gail K., Molski, Thaddeus F., Taber, Matthew T., Lodge, Nicholas J., Mattson, Ronald J., Macor, John E.

“…A series of amines with structure 10 were synthesized and tested for inhibition of the human serotonin transporter (hSERT). A series of racemic…”
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Conformationally restricted homotryptamines 3. Indole tetrahydropyridines and cyclohexenylamines as selective serotonin reuptake inhibitors by Deskus, Jeffrey A., Epperson, James R., Sloan, Charles P., Cipollina, Joseph A., Dextraze, Pierre, Qian-Cutrone, Jingfang, Gao, Qi, Ma, Baoqing, Beno, Brett R., Mattson, Gail K., Molski, Thaddeus F., Krause, Rudolph G., Taber, Matthew T., Lodge, Nicholas J., Mattson, Ronald J.

“…A series of indole tetrahydropyridine and indole cyclohexenylamines was prepared, and their binding affinities at the human serotonin transporter (SERT) were…”
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Synthesis and hSERT activity of homotryptamine analogs. Part 6: [3+2] dipolar cycloaddition of 3-vinylindoles by Marcin, Lawrence R., Mattson, Ronald J., Gao, Qi, Wu, Dedong, Molski, Thaddeus F., Mattson, Gail K., Lodge, Nicholas J.

“…A series of ring constrained homotryptamine analogs was prepared in 5 steps from 1-tosyl-3-vinylindoles via [3+2] dipolar cycloaddition with cyclic nitrones…”
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Synthesis and structure-activity relationships of N3-pyridylpyrazinones as corticotropin-releasing factor-1 (CRF1) receptor antagonists by HARTZ, Richard A, AHUJA, Vijay T, SCHMITZ, William D, MOLSKI, Thaddeus F, MATTSON, Gail K, LODGE, Nicholas J, BRONSON, Joanne J, MACOR, John E

“…A series of N(3)-pyridylpyrazinones was investigated as corticotropin-releasing factor-1 receptor antagonists. It was observed that the binding affinity of…”
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Conformationally restricted homotryptamines. Part 4: Heterocyclic and naphthyl analogs of a potent selective serotonin reuptake inhibitor by Dalton King, H., Denhart, Derek J., Deskus, Jeffrey A., Ditta, Jonathan L., Epperson, James R., Higgins, Mendi A., Kung, Joyce E., Marcin, Lawrence R., Sloan, Charles P., Mattson, Gail K., Molski, Thaddeus F., Krause, Rudolph G., Bertekap, Robert L., Lodge, Nicholas J., Mattson, Ronald J., Macor, John E.

“…Hybrid molecules containing the cyclopropylmethylamino side chain found in the parent homotryptamine system and an isosteric heteroaryl or naphthyl core were…”
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Synthesis and evaluation of 5,5-diphenylimidazolones as potent human neuropeptide Y5 receptor antagonists by Gillman, Kevin W., Higgins, Mendi A., Poindexter, Graham S., Browning, Marc, Clarke, Wendy J., Flowers, Sharon, Grace, James E., Hogan, John B., McGovern, Rachel T., Iben, Lawrence G., Mattson, Gail K., Ortiz, Astrid, Rassnick, Stefanie, Russell, John W., Antal-Zimanyi, Ildiko

“…A series of novel 5,5-diphenylimidazolones was synthesized and evaluated for activity against the human neuropeptide Y5 receptor. The 3-pyridyl analog 46…”
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Homotryptamines as potent and selective serotonin reuptake inhibitors (SSRIs) by Schmitz, William D., Denhart, Derek J., Brenner, Allison B., Ditta, Jonathan L., Mattson, Ronald J., Mattson, Gail K., Molski, Thaddeus F., Macor, John E.

“…A series of N, N-dimethylhomotryptamines was prepared and their binding affinities at the serotonin transporter (SERT) are reported. A series of N,…”
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Isosteric N-arylpiperazine replacements in a series of dihydropyridine NPY1 receptor antagonists by GUANGLIN LUO, MATTSON, Gail K, BRUCE, Marc A, WONG, Henry, MURPHY, Brian J, LONGHI, Daniel, ANTAL-ZIMANYI, Ildiko, POINDEXTER, Graham S

“…4-Amino-N-arylpiperidines serve as effective bioisosteres for N-arylpiperazines in the series of dihydropyridine NPY1 receptor antagonists. These were prepared…”
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Differentially functionalized diamines as novel ligands for the NPY2 receptor by ANDRES, Charles J, ZIMANYI, Ildiko Antal, DESHPANDE, Milind S, IBEN, Lawrence G, GRANT-YOUNG, Katharine, MATTSON, Gail K, WEIXU ZHAI

“…The synthesis of novel ligands for the NPY(2) receptor using solid phase split pool methodology is described. One of the analogues, diamine 16, was found to be…”
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Dihydropyridine neuropeptide Y Y1 receptor antagonists by POINDEXTER, Graham S, BRUCE, Marc A, MATTSON, Gail K, KOZLOWSKI, Michael, ARCURI, Meredith, ANTAL-ZIMANYI, Ildiko, LEBOULLUEC, Karen L, MONKOVIC, Ivo, MARTIN, Scott W, PARKER, Eric M, IBEN, Larry G, MCGOVERN, Rachel T, ORTIZ, Astrid A, STANLEY, Jennifer A

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Synthesis and structure–activity relationships of N 3-pyridylpyrazinones as corticotropin-releasing factor-1 (CRF 1) receptor antagonists by Hartz, Richard A., Ahuja, Vijay T., Schmitz, William D., Molski, Thaddeus F., Mattson, Gail K., Lodge, Nicholas J., Bronson, Joanne J., Macor, John E.

“…The structure–activity relationships of a series of N 3-pyridylpyrazinones as corticotropin-releasing factor-1 receptor antagonists was investigated. A series…”
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