Search Results - "Mattner, Filomena"

Synthesis and Biological Evaluation of Substituted [18F]Imidazo[1,2-a]pyridines and [18F]Pyrazolo[1,5-a]pyrimidines for the Study of the Peripheral Benzodiazepine Receptor Using Positron Emission Tomography by Fookes, Christopher J. R, Pham, Tien Q, Mattner, Filomena, Greguric, Ivan, Loc’h, Christian, Liu, Xiang, Berghofer, Paula, Shepherd, Rachael, Gregoire, Marie-Claude, Katsifis, Andrew

“…The fluoroethoxy and fluoropropoxy substituted 2-(6-chloro-2-phenyl)imidazo[1,2-a]pyridin-3-yl)-N,N-diethylacetamides 8 (PBR102) and 12 (PBR111) and…”
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Investigation of M1 M4 Muscarinic Receptors in the Anterior Cingulate Cortex in Schizophrenia, Bipolar Disorder, and Major Depression Disorder by Zavitsanou, Katerina, Katerina, Zavitsanou, Katsifis, Andrew, Andrew, Katsifis, Mattner, Filomena, Filomena, Mattner, Huang, Xu-Feng, Xu-Feng, Huang

“…Abnormal cholinergic neurotransmission has been suggested to occur in psychiatric illness. Therefore, this study investigated cholinergic muscarinic receptors…”
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Pharmacological evaluation of [123I]-CLINDE: a radioiodinated imidazopyridine-3-acetamide for the study of peripheral benzodiazepine binding sites (PBBS) by Mattner, Filomena, Mardon, Karine, Katsifis, Andrew

“…Purpose The study aims to evaluate the iodinated imidazopyridine, N ′, N ′-diethyl-6-Chloro-(4′-[ 123 I]iodophenyl)imidazo[1,2-a]pyridine-3-acetamide ([ 123…”
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Influence of trishomocubanes on sigma receptor binding of N-(1-benzyl-piperidin-4-yl)-4-[123I]iodobenzamide in vivo in the rat brain by Liu, Xiang, Mattner, Filomena, Katsifis, Andrew, Christie, MacDonald, Kassiou, Michael

“…Three new trishomocubane analogues based on the 4-azahexacyclo[5.4.1.0(2,6).0(3,10).0(5,9).0(8,11)] dodecane-3-ol skeleton have been synthesised and assessed…”
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Increased translocator protein (TSPO) binding throughout neurodevelopment in the perinatal phencyclidine rodent model of schizophrenia by Lum, Jeremy S., du Bois, Teresa M., Mattner, Filomena, Katsifis, Andrew, Brown, Samara J., Huang, Xu-Feng, Newell, Kelly A.

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Central nervous system expression and PET imaging of the translocator protein in relapsing-remitting experimental autoimmune encephalomyelitis by Mattner, Filomena, Staykova, Maria, Berghofer, Paula, Wong, Heng Jian, Fordham, Susan, Callaghan, Paul, Jackson, Timothy, Pham, Tien, Gregoire, Marie-Claude, Zahra, David, Rahardjo, Gita, Linares, David, Katsifis, Andrew

“…Glial neuroinflammation is associated with the development and progression of multiple sclerosis. PET imaging offers a unique opportunity to evaluate…”
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Synthesis and pharmacological evaluation of [F]PBR316: a novel PET ligand targeting the translocator protein 18 kDa (TSPO) with low binding sensitivity to human single nucleotide polymorphism rs6971 by Mattner, Filomena, Katsifis, Andrew, Bourdier, Thomas, Loc'h, Christian, Berghofer, Paula, Fookes, Christopher, Hung, Tzong-Tyng, Jackson, Timothy, Henderson, David, Pham, Tien, Lee, Brendan J, Shepherd, Rachael, Greguric, Ivan, Wyatt, Naomi, Le, Thanh, Poon, Jackson, Power, Carl, Fulham, Michael

“…Radiopharmaceuticals that target the translocator protein 18 kDa (TSPO) have been investigated with positron emission tomography (PET) to study…”
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PET imaging of brain inflammation during early epileptogenesis in a rat model of temporal lobe epilepsy by Dedeurwaerdere, Stefanie, Callaghan, Paul D, Pham, Tien, Rahardjo, Gita L, Amhaoul, Halima, Berghofer, Paula, Quinlivan, Mitchell, Mattner, Filomena, Loc'h, Christian, Katsifis, Andrew, Grégoire, Marie-Claude

“…Background Recently, inflammatory cascades have been suggested as a target for epilepsy therapy. Positron emission tomography (PET) imaging offers the unique…”
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Evaluation of [123I]-CLINDE as a potent SPECT radiotracer to assess the degree of astroglia activation in cuprizone-induced neuroinflammation by Mattner, Filomena, Bandin, David Linares, Staykova, Maria, Berghofer, Paula, Gregoire, Marie Claude, Ballantyne, Patrice, Quinlivan, Mitchell, Fordham, Susan, Pham, Tien, Willenborg, David O., Katsifis, Andrew

“…Purpose The purpose of this study was to assess the feasibility and sensitivity of the high-affinity translocator protein (TSPO) ligand [ 123 I]-CLINDE in…”
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Double Application of Translocator Protein Ligands and RAW Cells Inflammatory Milieu by Staykova, Maria, Mattner, Filomena, Linares, David, Katsifis, Andrew

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Evaluation of CLINDE as potent translocator protein (18 kDa) SPECT radiotracer reflecting the degree of neuroinflammation in a rat model of microglial activation by Arlicot, Nicolas, Katsifis, Andrew, Garreau, Lucette, Mattner, Filomena, Vergote, Jackie, Duval, Stéphanie, Bodard, Sylvie, Guilloteau, Denis, Chalon, Sylvie

“…Background The translocator protein (TSPO; 18 kDa), the new name of the peripheral-type benzodiazepine receptor, is localised in mitochondria of glial cells…”
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Discovery of [18F]N-(2-(Diethylamino)ethyl)-6-fluoronicotinamide: A Melanoma Positron Emission Tomography Imaging Radiotracer with High Tumor to Body Contrast Ratio and Rapid Renal Clearance by Greguric, Ivan, Taylor, Stephen R, Denoyer, Delphine, Ballantyne, Patrice, Berghofer, Paula, Roselt, Peter, Pham, Tien Q, Mattner, Filomena, Bourdier, Thomas, Neels, Oliver C, Dorow, Donna S, Loc’h, Christian, Hicks, Rodney J, Katsifis, Andrew

“…The high melanoma uptake and rapid body clearance displayed by our series of [123I]iodonicotinamides prompted the development of…”
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In vivo imaging of brain lesions with [11C]CLINME, a new PET radioligand of peripheral benzodiazepine receptors by Boutin, Hervé, Chauveau, Fabien, Thominiaux, Cyrille, Kuhnast, Bertrand, Grégoire, Marie-Claude, Jan, Sébastien, Trebossen, Régine, Dollé, Frédéric, Tavitian, Bertrand, Mattner, Filomena, Katsifis, Andrew

“…The peripheral benzodiazepine receptor (PBR) is expressed by microglial cells in many neuropathologies involving neuroinflammation. PK11195, the reference…”
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In vivo evaluation of the therapeutic potential of novel translocator protein (TSPO) ligands for the treatment of Alzheimer’s disease by Asih, Prita Riana, Ji, Bin, Katsifis, Andrew, Mattner, Filomena, Caruso, Donatella, Melcangi, Roberto Cosimo, Higuchi, Makoto, Martins, Ralph N, Barron, Anna M

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O1‐11‐02: In vivo evaluation of the therapeutic potential of novel translocator protein (TSPO) ligands for the treatment of Alzheimer's disease by Asih, Prita Riana, Ji, Bin, Katsifis, Andrew, Mattner, Filomena, Caruso, Donatella, Melcangi, Roberto Cosimo, Higuchi, Makoto, Martins, Ralph N., Barron, Anna M.

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Synthesis of [11C]PBR170, a novel imidazopyridine, for imaging the translocator protein with PET by Bourdier, Thomas, Henderson, David, Fookes, Christopher J.R., Lam, Peter, Mattner, Filomena, Fulham, Michael, Katsifis, Andrew

“…The translocator protein (TSPO) ligand 2-(6,8-dichloro-2-(4-ethoxyphenyl)imidazo[1,2-a]pyridin-3-yl)–N-(2-fluoropyridin-3-yl)–N-methylacetamide (PBR170), is a…”
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Pharmacological evaluation of an [ 123I] labelled imidazopyridine-3-acetamide for the study of benzodiazepine receptors by Mattner, Filomena, Mardon, Karine, Loc'h, Christian, Katsifis, Andrew

“…In vitro binding of the iodinated imidazopyridine, N′, N′-dimethyl-6-methyl-(4′-[ 123I]iodophenyl)imidazo[1,2-a]pyridine-3-acetamide [ 123I]IZOL to…”
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P4‐198: NOVEL TRANSLOCATOR PROTEIN (TSPO) LIGANDS FOR THE POTENTIAL TREATMENT OF ALZHEIMER'S DISEASE: A NEXT GENERATION ALTERNATIVE TO CONVENTIONAL HORMONE THERAPY by Asih, Prita Riana, Barron, Anna M., Ji, Bin, Katsifis, Andrew, Mattner, Filomena, Verdile, Giuseppe, Gupta, Veer Bala, Trengove, Rob, Martins, Ralph N.

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NOVEL TRANSLOCATOR PROTEIN (TSPO) LIGANDS FOR THE POTENTIAL TREATMENT OF ALZHEIMER'S DISEASE: A NEXT GENERATION ALTERNATIVE TO CONVENTIONAL HORMONE THERAPY by Asih, Prita Riana, Barron, Anna M, Ji, Bin, Katsifis, Andrew, Mattner, Filomena, Verdile, Giuseppe, Gupta, Veer Bala, Trengove, Rob, Martins, Ralph N

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A rapid solid-phase extraction method for measurement of non-metabolised peripheral benzodiazepine receptor ligands, [18 F]PBR102 and [18 F]PBR111, in rat and primate plasma by Katsifis, Andrew, Loc'h, Christian, Henderson, David, Bourdier, Thomas, Pham, Tien, Greguric, Ivan, Lam, Peter, Callaghan, Paul, Mattner, Filomena, Eberl, Stefan, Fulham, Michael

“…Abstract Objectives To develop a rapid and reliable method for estimating non-metabolised PBR ligands fluoroethoxy ([18 F]PBR102)- and fluoropropoxy ([18…”
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