Search Results - "Mattiuz, Giorgio"
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The RNA editing enzyme APOBEC1 induces somatic mutations and a compatible mutational signature is present in esophageal adenocarcinomas
Published in Genome biology (31-07-2014)“…The AID/APOBECs are deaminases that act on cytosines in a diverse set of pathways and some of them have been linked to the onset of genetic alterations in…”
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Effects of common Gram-negative pathogens causing male genitourinary-tract infections on human sperm functions
Published in Scientific reports (28-09-2021)“…Male genitourinary tract (MGT) bacterial infections are considered responsible for 15% of male infertility, but the mechanisms underlying decreased semen…”
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An elusive debate on the evidence for RNA editing in SARS-CoV-2
Published in RNA biology (2024)Get full text
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Vaginal Lactobacilli and Vaginal Dysbiosis-Associated Bacteria Differently Affect Cervical Epithelial and Immune Homeostasis and Anti-Viral Defenses
Published in International journal of molecular sciences (17-06-2021)“…Persistent infection with High Risk-Human Papilloma Viruses (HR-HPVs) is a primary cause of cervical cancer worldwide. Vaginal-dysbiosis-associated bacteria…”
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Author Correction: Effects of common Gram-negative pathogens causing male genitourinary-tract infections on human sperm functions
Published in Scientific reports (07-10-2021)Get full text
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COVID-19 annual update: a narrative review
Published in Human genomics (24-07-2023)“…Three and a half years after the pandemic outbreak, now that WHO has formally declared that the emergency is over, COVID-19 is still a significant global…”
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Prospective genetic germline evaluation in a consecutive group of adult patients aged <60 years with myelodysplastic syndromes
Published in HemaSphere (01-07-2024)“…Relevance of germline (GL) predisposition in myelodysplastic syndromes (MDSs) was stressed in both 2022 WHO and International Consensus classifications, but…”
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Splice variants of activation induced deaminase (AID) do not affect the efficiency of class switch recombination in murine CH12F3 cells
Published in PloS one (24-03-2015)“…Activation Induced Deaminase (AID) triggers the antigen-driven antibody diversification processes through its ability to edit DNA. AID dependent DNA damage is…”
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Hypervirulent Klebsiella pneumoniae Strains Modulate Human Dendritic Cell Functions and Affect TH1/TH17 Response
Published in Microorganisms (Basel) (07-02-2022)“…Hypervirulent Klebsiella pneumoniae (Hv-Kp) strains have emerged as pathogens causing life-threatening, invasive disease even in immunocompetent hosts…”
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Evidence for host-dependent RNA editing in the transcriptome of SARS-CoV-2
Published in Science advances (01-06-2020)“…The COVID-19 outbreak has become a global health risk, and understanding the response of the host to the SARS-CoV-2 virus will help to combat the disease. RNA…”
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Treatment with Oral Azacitidine in Elderly Patients with Higher Risk Myelodysplastic Syndromes after Response to Subcutaneous Azacitidine
Published in Blood (15-11-2022)Get full text
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The Combination of Decitabine Plus Venetoclax Is an Active Salvage Therapy for AML Post HR-MDS Progressed during Treatment with Azacitidine Based Regimens
Published in Blood (15-11-2022)Get full text
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TP53 VAF as an Easier Prognostic Indicator in Myelodysplastic Neoplasms in Comparison With Tp53 Allelic Status
Published in Clinical lymphoma, myeloma and leukemia (01-09-2024)Get full text
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MDS-679 TP53 VAF as an Easier Prognostic Indicator in Myelodysplastic Neoplasms in Comparison With Tp53 Allelic Status
Published in Clinical lymphoma, myeloma and leukemia (01-09-2024)“…Biallelic TP53 inactivation negatively affects overall survival (OS) and leukemia-free survival (LFS) of patients with myelodysplastic syndromes (MDS), whereas…”
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Treatment of Elderly Patients with Higher Risk Myelodysplastic Syndromes with Oral Azacitidine
Published in Blood (02-11-2023)“…Background Oral formulations ofhypomethylating agents decitabine (ASTX727) and azacitidine (cc-486, AZA) were approved respectively for treatment of higher…”
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Impact of Mutational Burden and IPSS-M on Response to ESAs in Lower Risk Myelodysplastic Neoplasms
Published in Blood (02-11-2023)“…INTRODUCTION Lower risk myelodysplastic neoplasms (LR-MDS), as defined by IPSS-R, are frequently presenting with anemia which is primarily treated with…”
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MDS-462 Response to Erythropoiesis-Stimulating Agent Therapy in IPSS-R Lower Risk Myelodysplastic Syndrome Patients Restratified According to IPSS-M
Published in Clinical lymphoma, myeloma and leukemia (01-09-2023)“…Erythropoiesis-stimulating agents (ESAs) are commonly used to treat anemic low-risk myelodysplastic syndrome (MDS) patients. Response to these agents is…”
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