Search Results - "Mattie, S."

C-type Lectin Mincle Recognizes Glucosyl-diacylglycerol of Streptococcus pneumoniae and Plays a Protective Role in Pneumococcal Pneumonia by Behler-Janbeck, Friederike, Takano, Tomotsugu, Maus, Regina, Stolper, Jennifer, Jonigk, Danny, Tort Tarrés, Meritxell, Fuehner, Thomas, Prasse, Antje, Welte, Tobias, Timmer, Mattie S M, Stocker, Bridget L, Nakanishi, Yoichi, Miyamoto, Tomofumi, Yamasaki, Sho, Maus, Ulrich A

“…Among various innate immune receptor families, the role of C-type lectin receptors (CLRs) in lung protective immunity against Streptococcus pneumoniae (S…”
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The trehalose glycolipid C18Brar promotes antibody and T-cell immune responses to Mannheimia haemolytica and Mycoplasma ovipneumoniae whole cell antigens in sheep by Gupta, Sandeep K, Parlane, Natalie, Bridgeman, Benjamin, Lynch, Amy T, Dangerfield, Emma M, Timmer, Mattie S M, Stocker, Bridget L, Wedlock, D Neil

“…Bronchopneumonia is a common respiratory disease in livestock. Mannheimia haemolytica is considered the main causative pathogen leading to lung damage in…”
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Synthesis of Branched Trehalose Glycolipids and Their Mincle Agonist Activity by Bird, Jessie H, Khan, Ashna A, Nishimura, Naoya, Yamasaki, Sho, Timmer, Mattie S. M, Stocker, Bridget L

“…The macrophage inducible C-type lectin (Mincle) is a pattern recognition receptor that recognizes trehalose dimycolate (TDM), and trehalose dibehenate (TDB)…”
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Lipidated Brartemicin Analogues Are Potent Th1-Stimulating Vaccine Adjuvants by Foster, Amy J, Nagata, Masahiro, Lu, Xiuyuan, Lynch, Amy T, Omahdi, Zakaria, Ishikawa, Eri, Yamasaki, Sho, Timmer, Mattie S. M, Stocker, Bridget L

“…Effective Th1-stimulating vaccine adjuvants typically activate antigen presenting cells (APCs) through pattern recognition receptors (PRRs). Macrophage…”
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Stereochemistry, lipid length and branching influences Mincle agonist activity of monoacylglycerides by Khan, Ayesha, Braganza, Chriselle D, Kodar, Kristel, Timmer, Mattie S M, Stocker, Bridget L

“…Herein, we report on the synthesis of a series of enantiomerically pure linear, iso-branched, and α-branched monoacyl glycerides (MAGs) in 63-72% overall…”
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Lipophilic glucose monoesters and glycosides are potent human Mincle agonists by Braganza, Chriselle D, Kodar, Kristel, Teunissen, Thomas, Andreassend, Sarah K, Khan, Ayesha, Timmer, Mattie S M, Stocker, Bridget L

“…Macrophage inducible C-type lectin (Mincle) is a pattern recognition receptor on myeloid cells that represents a promising target for Th1-stimulating…”
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Chimeric NOD2 Mincle Agonists as Vaccine Adjuvants by Dangerfield, Emma M., Ishizuka, Shigenari, Kodar, Kristel, Yamasaki, Sho, Timmer, Mattie S. M., Stocker, Bridget L.

“…There is a need for improved vaccine adjuvants to augment vaccine efficacy. One way to address this is by targeting multiple immune cell pathogen recognition…”
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Agonistic or antagonistic mucosal-associated invariant T (MAIT) cell activity is determined by the 6-alkylamino substituent on uracil MR1 ligands by Braganza, Chriselle D, Motozono, Chihiro, Sonoda, Koh-Hei, Yamasaki, Sho, Shibata, Kensuke, Timmer, Mattie S M, Stocker, Bridget L

“…Mucosal-associated invariant T (MAIT) are a subset of innate-like T cells that are activated by uracil ligands presented by MR1. For the first time, we…”
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Recent Developments in the Synthesis of Pyrrolidine-Containing Iminosugars by Stocker, Bridget L., Dangerfield, Emma M., Win-Mason, Anna L., Haslett, Gregory W., Timmer, Mattie S. M.

“…As noted inhibitors of glycosidases, iminosugars have enormous therapeutic potential in the treatment of a number of diseases such as cancer, diabetes, and…”
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Protecting-Group-Free Synthesis of Amines: Synthesis of Primary Amines from Aldehydes via Reductive Amination by Dangerfield, Emma M, Plunkett, Catherine H, Win-Mason, Anna L, Stocker, Bridget L, Timmer, Mattie S. M

“…New methodology for the protecting-group-free synthesis of primary amines is presented. By optimizing the metal hydride/ammonia mediated reductive amination of…”
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Energy Transfer between Anthracene-9-carboxylic Acid Ligands and CsPbBr3 and CsPbI3 Nanocrystals by Hardy, Jake, Brett, Matthew W, Rossi, Aurélien, Wagner, Isabella, Chen, Kai, Timmer, Mattie S. M, Stocker, Bridget L, Price, Michael B, Davis, Nathaniel J. L. K

“…Cesium lead halide perovskite nanocrystals show great promise for optoelectronic applications due to their thermal stability, wide absorption range, and…”
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Helicobacter pylori metabolites exacerbate gastritis through C-type lectin receptors by Nagata, Masahiro, Toyonaga, Kenji, Ishikawa, Eri, Haji, Shojiro, Okahashi, Nobuyuki, Takahashi, Masatomo, Izumi, Yoshihiro, Imamura, Akihiro, Takato, Koichi, Ishida, Hideharu, Nagai, Shigenori, Illarionov, Petr, Stocker, Bridget L., Timmer, Mattie S.M., Smith, Dylan G.M., Williams, Spencer J., Bamba, Takeshi, Miyamoto, Tomofumi, Arita, Makoto, Appelmelk, Ben J., Yamasaki, Sho

“…Helicobacter pylori causes gastritis, which has been attributed to the development of H. pylori–specific T cells during infection. However, the mechanism…”
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The effect of MR1 ligand glyco-analogues on mucosal-associated invariant T (MAIT) cell activation by Braganza, Chriselle D, Shibata, Kensuke, Fujiwara, Aisa, Motozono, Chihiro, Sonoda, Koh-Hei, Yamasaki, Sho, Stocker, Bridget L, Timmer, Mattie S M

“…Mucosal-associated invariant T (MAIT) cells are a subset of recently identified innate-like T lymphocytes that appear to play an important role in many…”
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Identification and Biological Activity of Synthetic Macrophage Inducible C-Type Lectin Ligands by Braganza, Chriselle D, Teunissen, Thomas, Timmer, Mattie S M, Stocker, Bridget L

“…The macrophage inducible C-type lectin (Mincle) is a pattern recognition receptor able to recognize both damage-associated and pathogen-associated molecular…”
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The NKT cell TCR repertoire can accommodate structural modifications to the lipid and orientation of the terminal carbohydrate of iGb3 by Cameron, Garth, Cheng, Janice M. H, Godfrey, Dale I, Timmer, Mattie S. M, Stocker, Bridget L, Dangerfield, Emma M

“…Isoglobotrihexosylceramide (iGb3) is a known NKT cell agonist, however the specific interactions required to trigger NKT cell TCR activation in response to…”
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Amide-linked brartemicin glycolipids exhibit Mincle-mediated agonist activity in vitro by Dangerfield, Emma M., Lynch, Amy T., Kodar, Kristel, Stocker, Bridget L., Timmer, Mattie S.M.

“…Lipidated derivatives of the natural product brartemicin show much promise as vaccine adjuvants due to their ability to signal through the Macrophage Inducible…”
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Chemical Tools for Studying the Biological Function of Glycolipids by Stocker, Bridget L., Timmer, Mattie S. M.

“…Glycolipids play an important role in many biological processes and to this end, synthetic chemists have developed a variety of new techniques and “chemical…”
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The effects of trehalose glycolipid presentation on cytokine production by GM-CSF macrophages by Stocker, Bridget L., Kodar, Kristel, Wahi, Kanu, Foster, Amy J., Harper, Jacquie L., Mori, Daiki, Yamasaki, Sho, Timmer, Mattie S. M.

“…Trehalose glycolipids (TGLs) are promising vaccine adjuvants, however effects of glycolipid presentation in the in vitro evaluation, and ultimate selection, of…”
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Aryl-functionalised α,α′-Trehalose 6,6′-Glycolipid Induces Mincle-independent Pyroptotic Cell Death by Kodar, Kristel, Dangerfield, Emma M., Foster, Amy J., Forsythe, Devlin, Ishizuka, Shigenari, McConnell, Melanie J., Yamasaki, Sho, Timmer, Mattie S. M., Stocker, Bridget L.

“…— α,α′-Trehalose 6,6′-glycolipids have long been known for their immunostimulatory properties. The adjuvanticity of α,α′-trehalose 6,6′-glycolipids is mediated…”
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Synthesis and glycosidase inhibition of 3,4,5-trihydroxypiperidines using a one-pot amination-cyclisation cascade reaction by Dangerfield, Emma M., Meijlink, Michael A., Hunt-Painter, Alex A., Nasseri, Seyed A., Withers, Stephen G., Stocker, Bridget L., Timmer, Mattie S.M.

“…Trihydroxypiperidines are a therapeutically valuable class of iminosugar. We applied a one-pot amination-cyclisation cascade reaction to synthesise…”
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