Search Results - "Mattie, David R"

Sub-chronic dermal exposure to aircraft engine oils impacts the reproductive organ weights and alters hematological profiles of Sprague Dawley rats by Sibomana, Isaie, Mattie, David R.

“…There is little data available for the toxicity of used aircraft engine oils relative to their unused (new) versions. This study was conducted to determine if…”
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Complex Mixtures: Array PBPK Modeling of Jet Fuel Components by Sterner, Teresa R, Covington, Tammie R, Mattie, David R

“…An array physiologically-based pharmacokinetic (PBPK) model represents a streamlined method to simultaneously quantify dosimetry of multiple compounds. To…”
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Acute dermal toxicity study of new, used and laboratory aged aircraft engine oils by Sibomana, Isaie, Good, Neal A., Hellman, Patrick T., Rosado, Lewis, Mattie, David R.

“…[Display omitted] •Aircraft engine oils 4 h dermal exposures induced slight skin irritation in rabbits.•Used oils enhanced irritation under semi-occlusive…”
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Background Noise Contributes to Organic Solvent Induced Brain Dysfunction by Ortiz, Pedro A., Reboulet, James E., McInturf, Shawn M., Wong, Brian A., Guthrie, O’neil, Mattie, David R.

“…Occupational exposure to complex blends of organic solvents is believed to alter brain functions among workers. However, work environments that contain organic…”
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21-Day dermal exposure to aircraft engine oils: effects on esterase activities in brain and liver tissues, blood, plasma, and clinical chemistry parameters for Sprague Dawley rats by Sibomana, Isaie, Rohan, Joyce G., Mattie, David R.

“…This dermal study tested the potential toxicity of grade 3 (G3) and 4 (G4) organophosphate-containing aircraft engine oils in both new (G3-N, G4-N) and used…”
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Evaluation of perturbations in serum thyroid hormones during human pregnancy due to dietary iodide and perchlorate exposure using a biologically based dose-response model by Lumen, Annie, Mattie, David R, Fisher, Jeffrey W

“…A biologically based dose-response model (BBDR) for the hypothalamic pituitary thyroid (HPT) axis was developed in the near-term pregnant mother and fetus…”
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Degenerate brainstem circuitry after combined physiochemical exposure to jet fuel and noise by Guthrie, O'neil W., Wong, Brian A., McInturf, Shawn M., Mattie, David R.

“…Degenerate neural circuits exhibit "different" circuit properties yet produce similar circuit outcomes (many-to-one) which ensures circuit robustness and…”
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In Vitro Aerosol Exposure to Nanomaterials: From Laboratory to Environmental Field Toxicity Testing by Tilly, Trevor B, Nelson, M. Tyler, Chakravarthy, Karthik B, Shira, Emily A, Debrose, Madeline C, Grabinski, Christin M, Salisbury, Richard L, Mattie, David R, Hussain, Saber M

“…Exposure to nanomaterials (NMs) is inevitable, requiring robust toxicological assessment to understand potential environmental and human health effects. NMs…”
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Toxicity and human health assessment of an alcohol-to-jet (ATJ) synthetic kerosene by Mattie, David R., Wong, Brian A., Mumy, Karen L., McInturf, Shawn M., Grimm, Michael D., Gargas, Nathan, M., Shafer, Linda M., Striebich, Richard C., Sterner, Teresa R.

“…A toxicological investigation was conducted for alcohol-to-jet (ATJ) fuels intended as a 50:50 blend with petroleum-derived fuel Jet Propulsion (JP)-8. The ATJ…”
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Toxicity and occupational exposure assessment for hydroprocessed esters and fatty acids (HEFA) alternative jet fuels by Sterner, Teresa R., Wong, Brian A., Mumy, Karen L., James, R. Arden, Reboulet, James, Dodd, Darol E., Striebich, Richard C., Mattie, David R.

“…The U.S. Air Force (USAF) has pursued development of alternative fuels to augment or replace petroleum-based jet fuels. Hydroprocessed esters and fatty acids…”
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Acute and two-week inhalation toxicity studies in rats for Polyalphaolefin (PAO) fluid by Mattie, David R., Wegner, Matthew D., Wong, Brian A., James, R. Arden, Mumy, Karen L., McInturf, Shawn M., Marcel, Barry J., Sterner, Teresa R.

“…Formal occupational exposure limits (OELs) for polyalphaolefin (PAO) fluids have not been proposed. Specific PAO fluids are utilized as aircraft hydraulics or…”
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Inhalation of Hydrocarbon Jet Fuel Suppress Central Auditory Nervous System Function by Guthrie, O'neil W., Wong, Brian A., McInturf, Shawn M., Reboulet, James E., Ortiz, Pedro A., Mattie, David R.

“…More than 800 million L/d of hydrocarbon fuels is used to power cars, boats, and jet airplanes. The weekly consumption of these fuels necessarily puts the…”
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Toxicity and occupational exposure assessment for Fischer-Tropsch synthetic paraffinic kerosene by Mattie, David R., Sterner, Teresa R., Reddy, Gunda, Steup, David R., Zeiger, Errol, Wagner, Dean J., Kurtz, Katherine, Daughtrey, Wayne C., Wong, Brian A., Dodd, Darol E., Edwards, James T., Hinz, John P.

“…Fischer-Tropsch (FT) Synthetic Paraffinic Kerosene (SPK) jet fuel is a synthetic organic mixture intended to augment petroleum-derived JP-8 jet fuel use by the…”
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Exposure to Low Levels of Jet-Propulsion Fuel Impairs Brainstem Encoding of Stimulus Intensity by Guthrie, O'neil W., Xu, Helen, Wong, Brian A., McInturf, Shawn M., Reboulet, Jim E., Ortiz, Pedro A., Mattie, David R.

“…Jet propulsion fuel-8 (JP-8) is a kerosene-based fuel that is used in military jets. The U.S. Armed Services and North Atlantic Treaty Organization countries…”
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Lipid, water, and protein composition to facilitate kinetic modeling of the auditory pathway by Grobe, Nadja, Narayanan, Latha, Brown, Dominique N., Law, Sarah T., Sibomana, Isaie, Shiyanov, Pavel, Reo, Nicholas V., Hack, C. Eric, Sterner, Teresa R., Mattie, David R.

“…Environments combining JP-8 jet fuel exposure with heightened ambient noise may accelerate hearing loss induced by noise. To reduce animal use and facilitate…”
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Past, present and emerging toxicity issues for jet fuel by Mattie, David R., Sterner, Teresa R.

“…The US Air Force wrote the specification for the first official hydrocarbon-based jet fuel, JP-4, in 1951. This paper will briefly review the toxicity of the…”
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Perchlorate and Radioiodide Kinetics Across Life Stages in the Human: Using PBPK Models to Predict Dosimetry and Thyroid Inhibition and Sensitive Subpopulations Based on Developmental Stage by Clewell, Rebecca A., Merrill, Elaine A., Gearhart, Jeffery M., Robinson, Peter J., Sterner, Teresa R., Mattie, David R., Clewell, Harvey J.

“…Perchlorate (ClO 4 −  ) is a drinking-water contaminant, known to disrupt thyroid hormone homeostasis in rats. This effect has only been seen in humans at high…”
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The Pharmacokinetics of Perchlorate and Its Effect on the Hypothalamus–Pituitary–Thyroid Axis in the Male Rat by Yu, Kyung O., Narayanan, Latha, Mattie, David R., Godfrey, Richard J., Todd, Paula N., Sterner, Teresa R., Mahle, Deirdre A., Lumpkin, Michael H., Fisher, Jeffrey W.

“…Perchlorate, an environmental contaminant, is known to disturb the hypothalamus–pituitary–thyroid (HPT) axis by blocking iodide accumulation in the thyroid…”
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Low-Dose Effects of Ammonium Perchlorate on the Hypothalamic-Pituitary-Thyroid Axis of Adult Male Rats Pretreated with PCB126 by McLanahan, Eva D., Campbell, Jerry L., Ferguson, Duncan C., Harmon, Barry, Hedge, Joan M., Crofton, Kevin M., Mattie, David R., Braverman, Lewis, Keys, Deborah A., Mumtaz, Moiz, Fisher, Jeffrey W.

“…The objective of this research was to characterize the disturbances in the hypothalamic-pituitary-thyroid (HPT) axis resulting from exposure to a binary…”
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Predicting Fetal Perchlorate Dose and Inhibition of Iodide Kinetics during Gestation: A Physiologically-Based Pharmacokinetic Analysis of Perchlorate and Iodide Kinetics in the Rat by Clewell, Rebecca A., Merrill, Elaine A., Yu, Kyung O., Mahle, Deirdre A., Sterner, Teresa R., Mattie, David R., Robinson, Peter J., Fisher, Jeffrey W., Gearhart, Jeffery M.

“…Perchlorate (ClO4−) disrupts endocrine homeostasis by competitively inhibiting the transport of iodide (I−) into the thyroid. The potential for health effects…”
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