Search Results - "Mattick, J. S"

Long noncoding RNAs and the genetics of cancer by Cheetham, S W, Gruhl, F, Mattick, J S, Dinger, M E

“…Cancer is a disease of aberrant gene expression. While the genetic causes of cancer have been intensively studied, it is becoming evident that a large…”
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The long non-coding RNA Gomafu is acutely regulated in response to neuronal activation and involved in schizophrenia-associated alternative splicing by Barry, G, Briggs, J A, Vanichkina, D P, Poth, E M, Beveridge, N J, Ratnu, V S, Nayler, S P, Nones, K, Hu, J, Bredy, T W, Nakagawa, S, Rigo, F, Taft, R J, Cairns, M J, Blackshaw, S, Wolvetang, E J, Mattick, J S

“…Schizophrenia (SZ) is a complex disease characterized by impaired neuronal functioning. Although defective alternative splicing has been linked to SZ, the…”
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Intergenic disease-associated regions are abundant in novel transcripts by Bartonicek, N, Clark, M B, Quek, X C, Torpy, J R, Pritchard, A L, Maag, J L V, Gloss, B S, Crawford, J, Taft, R J, Hayward, N K, Montgomery, G W, Mattick, J S, Mercer, T R, Dinger, M E

“…Genotyping of large populations through genome-wide association studies (GWAS) has successfully identified many genomic variants associated with traits or…”
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Non-coding RNAs: the architects of eukaryotic complexity by Mattick, John S

“…Around 98% of all transcriptional output in humans is non‐coding RNA. RNA‐mediated gene regulation is widespread in higher eukaryotes and complex genetic…”
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The evolution of controlled multitasked gene networks: the role of introns and other noncoding RNAs in the development of complex organisms by Mattick, J S, Gagen, M J

“…Eukaryotic phenotypic diversity arises from multitasking of a core proteome of limited size. Multitasking is routine in computers, as well as in other…”
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Touchdown PCR to circumvent spurious priming during gene amplification by DON, R. H, COX, P. T, WAINWRIGHT, B. J, BAKER, K, MATTICK, J. S

“…We devised a simple solution taking advantage of the exponential nature of PCR reactions, and which begins at or above, rather than below, the expected…”
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Accelerating, hyperaccelerating, and decelerating networks by Gagen, M J, Mattick, J S

“…Many growing networks possess accelerating statistics where the number of links added with each new node is an increasing function of network size so the total…”
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A re-examination of twitching motility in Pseudomonas aeruginosa by Semmler, Annalese B. T, Whitchurch, Cynthia B, Mattick, John S

“…Centre for Molecular and Cellular Biology 1 and Department of Biochemistry 2 , University of Queensland, Brisbane, QLD 4072, Australia Author for…”
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Pseudomonas aeruginosa Gene Products PilT and PilU Are Required for Cytotoxicity In Vitro and Virulence in a Mouse Model of Acute Pneumonia by COMOLLI, J. C, HAUSER, A. R, WAITE, L, WHITCHURCH, C. B, MATTICK, J. S, ENGEL, J. N

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Common components in the assembly of type 4 fimbriae, DNA transfer systems, filamentous phage and protein-secretion apparatus: a general system for the formation of surface-associated protein complexes by Hobbs, M, Mattick, J S

“…The Pseudomonas aeruginosa genes pilB-D and pilQ are necessary for the assembly of type 4 fimbriae. Homologues of these genes and of the subunit (pilin) gene…”
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TYPE IV PILI AND TWITCHING MOTILITY by Mattick, John S

“…Twitching motility is a flagella-independent form of bacterial translocation over moist surfaces. It occurs by the extension, tethering, and then retraction of…”
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Challenging the dogma: the hidden layer of non-protein-coding RNAs in complex organisms by Mattick, John S.

“…The central dogma of biology holds that genetic information normally flows from DNA to RNA to protein. As a consequence it has been generally assumed that…”
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Rapid evolution of noncoding RNAs: lack of conservation does not mean lack of function by Pang, Ken C., Frith, Martin C., Mattick, John S.

“…The mammalian transcriptome contains many non-protein-coding RNAs (ncRNAs), but most of these are of unclear significance and lack strong sequence…”
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The conservation of dinucleotide microsatellites among mammalian genomes allows the use of heterologous PCR primer pairs in closely related species by Moore, S S, Sargeant, L L, King, T J, Mattick, J S, Georges, M, Hetzel, D J

“…The high degree of polymorphism displayed by DNA microsatellites makes them useful as DNA markers in linkage studies. A search of the DNA sequence databases…”
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PilS and PilR, a two-component transcriptional regulatory system controlling expression of type 4 fimbriae in Pseudomonas aeruginosa by Hobbs, M, Collie, E S, Free, P D, Livingston, S P, Mattick, J S

“…Transposon mutagenesis was used to identify genes necessary for the expression of Pseudomonas aeruginosa type 4 fimbriae. In a library of 12,700 mutants, 147…”
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Large-Scale Appearance of Ultraconserved Elements in Tetrapod Genomes and Slowdown of the Molecular Clock by Stephen, Stuart, Pheasant, Michael, Makunin, Igor V., Mattick, John S.

“…Mammalian genomes contain millions of highly conserved noncoding sequences, many of which are regulatory. The most extreme examples are the 481 ultraconserved…”
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Characterization of a gene, pilU, required for twitching motility but not phage sensitivity in Pseudomonas aeruginosa by Whitchurch, C B, Mattick, J S

“…Type 4 fimbriae (or pilli) are associated with a form of bacterial surface translocation known as twitching motility. Fimbriae are also associated with…”
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Extracellular DNA Required for Bacterial Biofilm Formation by Whitchurch, Cynthia B., Tolker-Nielsen, Tim, Ragas, Paula C., Mattick, John S.

“…Bacterial biofilms are structures communities of cells enclosed in self-produced hydrated polymeric matrix adherent to an inert or living surface. Formation of…”
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Conservation of the Regulatory Subunit for the Clp ATP-Dependent Protease in Prokaryotes and Eukaryotes by Gottesman, Susan, Squires, Craig, Pichersky, Eran, Carrington, Mark, Hobbs, Matthew, Mattick, John S., Dalrymple, Brian, Kuramitsu, Howard, Shiroza, Teruaki, Foster, Toshi, Clark, William P., Ross, Barbara, Squires, Catherine L., Maurizi, Michael R.

“…Bacteria, tomatoes, and trypanosomes all contain genes for a large protein with extensive homology to the regulatory subunit, ClpA, of the ATP-dependent…”
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The Alginate Regulator AlgR and an Associated Sensor FimS are Required for Twitching Motility in Pseudomonas aeruginosa by Whitchurch, Cynthia B., Alm, Richard A., Mattick, John S.

“…Mucoid strains of Pseudomonas aeruginosa isolated from the lungs of cystic fibrosis patients produce large amounts of the exopolysaccharide alginate. AlgR has…”
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