Search Results - "Matthies, J G"

Closer Look at Amphetamine-Induced Reverse Transport and Trafficking of the Dopamine and Norepinephrine Transporters by Robertson, S. D, Matthies, H. J. G, Galli, A

“…Amphetamine (AMPH) and its derivatives are regularly used in the treatment of a wide array of disorders such as attention-deficit hyperactivity disorder…”
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mTORC2/rictor signaling disrupts dopamine-dependent behaviors via defects in striatal dopamine neurotransmission by Dadalko, Olga I, Siuta, Michael, Poe, Amanda, Erreger, Kevin, Matthies, Heinrich J G, Niswender, Kevin, Galli, Aurelio

“…Disrupted neuronal protein kinase B (Akt) signaling has been associated with dopamine (DA)-related neuropsychiatric disorders, including schizophrenia, a…”
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Impaired striatal Akt signaling disrupts dopamine homeostasis and increases feeding by Speed, Nicole, Saunders, Christine, Davis, Adeola R, Owens, W Anthony, Matthies, Heinrich J G, Saadat, Sanaz, Kennedy, Jack P, Vaughan, Roxanne A, Neve, Rachael L, Lindsley, Craig W, Russo, Scott J, Daws, Lynette C, Niswender, Kevin D, Galli, Aurelio

“…The prevalence of obesity has increased dramatically worldwide. The obesity epidemic begs for novel concepts and therapeutic targets that cohesively address…”
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Insulin reveals Akt signaling as a novel regulator of norepinephrine transporter trafficking and norepinephrine homeostasis by Robertson, Sabrina D, Matthies, Heinrich J G, Owens, W Anthony, Sathananthan, Vidiya, Christianson, Nicole S Bibus, Kennedy, J Phillip, Lindsley, Craig W, Daws, Lynette C, Galli, Aurelio

“…Noradrenergic signaling in the CNS plays an essential role in circuits involving attention, mood, memory, and stress as well as providing pivotal support for…”
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Ceramidase Regulates Synaptic Vesicle Exocytosis and Trafficking by Rohrbough, Jeffrey, Rushton, Emma, Palanker, Laura, Woodruff, Elvin, Matthies, Heinrich J. G, Acharya, Usha, Acharya, Jairaj K, Broadie, Kendal

“…A screen for Drosophila synaptic dysfunction mutants identified slug-a-bed (slab). The slab gene encodes ceramidase, a central enzyme in sphingolipid…”
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Gamma-tubulin is required for bipolar spindle assembly and for proper kinetochore microtubule attachments during prometaphase I in Drosophila oocytes by Hughes, Stacie E, Beeler, J Scott, Seat, Angela, Slaughter, Brian D, Unruh, Jay R, Bauerly, Elisabeth, Matthies, Heinrich J G, Hawley, R Scott

“…In many animal species the meiosis I spindle in oocytes is anastral and lacks centrosomes. Previous studies of Drosophila oocytes failed to detect the native…”
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Amphetamine actions at the serotonin transporter rely on the availability of phosphatidylinositol-4,5-bisphosphate by Buchmayer, Florian, Schicker, Klaus, Steinkellner, Thomas, Geier, Petra, Stübiger, Gerald, Hamilton, Peter J., Jurik, Andreas, Stockner, Thomas, Yang, Jae-Won, Montgomery, Therese, Holy, Marion, Hofmaier, Tina, Kudlacek, Oliver, Matthies, Heinrich J. G., Ecker, Gerhard F., Bochkov, Valery, Galli, Aurelio, Boehm, Stefan, Sitte, Harald H.

“…Nerve functions require phosphatidylinositol-4,5-bisphosphate (PIP ₂) that binds to ion channels, thereby controlling their gating. Channel properties are also…”
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SLC6A3 coding variant Ala559Val found in two autism probands alters dopamine transporter function and trafficking by Bowton, E, Saunders, C, Reddy, I A, Campbell, N G, Hamilton, P J, Henry, L K, Coon, H, Sakrikar, D, Veenstra-VanderWeele, J M, Blakely, R D, Sutcliffe, J, Matthies, H J G, Erreger, K, Galli, A

“…Emerging evidence associates dysfunction in the dopamine (DA) transporter (DAT) with the pathophysiology of autism spectrum disorder (ASD). The human DAT…”
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Autism-Associated Variant in the SLC6A3 Gene Alters the Oral Microbiome and Metabolism in a Murine Model by DiCarlo, Gabriella E, Mabry, Samuel J, Cao, Xixi, McMillan, Clara, Woynaroski, Tiffany G, Harrison, Fiona E, Reddy, India A, Matthies, Heinrich J G, Flynn, Charles R, Wallace, Mark T, Wu, Hui, Galli, Aurelio

“…Altered dopamine (DA) signaling has been associated with autism spectrum disorder (ASD), a neurodevelopmental condition estimated to impact 1 in 54 children in…”
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Subcellular localization of the antidepressant-sensitive norepinephrine transporter by Matthies, Heinrich J G, Han, Qiao, Shields, Angela, Wright, Jane, Moore, Jessica L, Winder, Danny G, Galli, Aurelio, Blakely, Randy D

“…Reuptake of synaptic norepinephrine (NE) via the antidepressant-sensitive NE transporter (NET) supports efficient noradrenergic signaling and presynaptic NE…”
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Yohimbine Depresses Excitatory Transmission in BNST and Impairs Extinction of Cocaine Place Preference Through Orexin-Dependent, Norepinephrine-Independent Processes by CONRAD, Kelly L, DAVIS, Adeola R, WINDER, Danny G, SILBERMAN, Yuval, SHEFFLER, Douglas J, SHIELDS, Angela D, SALEH, Sam A, SEN, Namita, MATTHIES, Heinrich J. G, JAVITCH, Jonathan A, LINDSLEY, Craig W

“…The alpha2 adrenergic receptor (α(2)-AR) antagonist yohimbine is a widely used tool for the study of anxiogenesis and stress-induced drug-seeking behavior. We…”
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Rab11 supports amphetamine-stimulated norepinephrine transporter trafficking by Matthies, Heinrich J G, Moore, Jessica L, Saunders, Christine, Matthies, Dawn Signor, Lapierre, Lynne A, Goldenring, James R, Blakely, Randy D, Galli, Aurelio

“…The norepinephrine transporter (NET) is a presynaptic plasma membrane protein that mediates reuptake of synaptically released norepinephrine. NET is also a…”
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Sodium-dependent vitamin C transporter-2 mediates vitamin C transport at the cortical nerve terminal by Pierce, Marquicia R., Raj, Amita, Betke, Katherine M., Zeidan, L. Nora, Matthies, Heinrich J.G., May, James M.

“…It has been shown that vitamin C (VC) is transported at synaptic boutons, but how this occurs has not been elucidated. This study investigates the role of the…”
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Integrins regulate DLG/FAS2 via a CaM kinase II-dependent pathway to mediate synapse elaboration and stabilization during postembryonic development by Beumer, Kelly, Matthies, Heinrich J G, Bradshaw, Amber, Broadie, Kendal

“…Calcium/calmodulin dependent kinase II (CaMKII), PDZ-domain scaffolding protein Discs-large (DLG), immunoglobin superfamily cell adhesion molecule Fasciclin 2…”
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Psychomotor impairments and therapeutic implications revealed by a mutation associated with infantile Parkinsonism-Dystonia by Aguilar, Jenny I, Cheng, Mary Hongying, Font, Josep, Schwartz, Alexandra C, Ledwitch, Kaitlyn, Duran, Amanda, Mabry, Samuel J, Belovich, Andrea N, Zhu, Yanqi, Carter, Angela M, Shi, Lei, Kurian, Manju A, Fenollar-Ferrer, Cristina, Meiler, Jens, Ryan, Renae Monique, Mchaourab, Hassane S, Bahar, Ivet, Matthies, Heinrich Jg, Galli, Aurelio

“…Parkinson disease (PD) is a progressive, neurodegenerative disorder affecting over 6.1 million people worldwide. Although the cause of PD remains unclear,…”
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Akt-Dependent and Isoform-Specific Regulation of Dopamine Transporter Cell Surface Expression by Speed, Nicole K, Matthies, Heinrich J. G, Kennedy, J. Phillip, Vaughan, Roxanne A, Javitch, Jonathan A, Russo, Scott J, Lindsley, Craig W, Niswender, Kevin, Galli, Aurelio

“…Dopamine (DA) is a neurotransmitter implicated in multiple functions, including movement, cognition, motivation, and reward. The DA transporter (DAT) is…”
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PIP2 regulates psychostimulant behaviors through its interaction with a membrane protein by Hamilton, Peter J, Belovich, Andrea N, Khelashvili, George, Saunders, Christine, Erreger, Kevin, Javitch, Jonathan A, Sitte, Harald H, Weinstein, Harel, Matthies, Heinrich J G, Galli, Aurelio

“…PIP 2 binds via electrostatic interactions to the N terminus of the dopamine transporter (DAT) to modulate its function in dopamine efflux. This regulation is…”
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A network of phosphatidylinositol (4,5)-bisphosphate (PIP2) binding sites on the dopamine transporter regulates amphetamine behavior in Drosophila Melanogaster by Belovich, Andrea N., Aguilar, Jenny I., Mabry, Samuel J., Cheng, Mary H., Zanella, Daniele, Hamilton, Peter J., Stanislowski, Daniel J., Shekar, Aparna, Foster, James D., Bahar, Ivet, Matthies, Heinrich J. G., Galli, Aurelio

“…Reward modulates the saliency of a specific drug exposure and is essential for the transition to addiction. Numerous human PET–fMRI studies establish a link…”
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Structural, functional, and behavioral insights of dopamine dysfunction revealed by a deletion in SLC6A3 by Campbell, Nicholas G., Shekar, Aparna, Aguilar, Jenny I., Peng, Dungeng, Navratna, Vikas, Yang, Dongxue, Morley, Alexander N., Duran, Amanda M., Galli, Greta, O’Grady, Brian, Ramachandran, Ramnarayan, Sutcliffe, James S., Sitte, Harald H., Erreger, Kevin, Meiler, Jens, Stockner, Thomas, Bellan, Leon M., Matthies, Heinrich J. G., Gouaux, Eric, Mchaourab, Hassane S., Galli, Aurelio

“…The human dopamine (DA) transporter (hDAT) mediates clearance of DA. Genetic variants in hDAT have been associated with DA dysfunction, a complication…”
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De novo mutation in the dopamine transporter gene associates dopamine dysfunction with autism spectrum disorder by Hamilton, P J, Campbell, N G, Sharma, S, Erreger, K, Herborg Hansen, F, Saunders, C, Belovich, A N, Sahai, M A, Cook, E H, Gether, U, Mchaourab, H S, Matthies, H J G, Sutcliffe, J S, Galli, A

“…De novo genetic variation is an important class of risk factors for autism spectrum disorder (ASD). Recently, whole-exome sequencing of ASD families has…”
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