Search Results - "Matthews, RC"

Fungal heat-shock proteins in human disease by Burnie, James P., Carter, Tracey L., Hodgetts, Samantha J., Matthews, Ruth C.

“…Abstract Heat-shock proteins (hsps) have been identified as molecular chaperones conserved between microbes and man and grouped by their molecular mass and…”
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Preclinical Assessment of the Efficacy of Mycograb, a Human Recombinant Antibody against Fungal HSP90 by MATTHEWS, Ruth C, RIGG, Gordon, HODGETTS, Samantha, CARTER, Tracey, CHAPMAN, Caroline, GREGORY, Carl, ILLIDGE, Chris, BURNIE, James

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Recombinant antibodies: a natural partner in combinatorial antifungal therapy by Matthews, Ruth C, Burnie, James P

“…Monotherapy, in the form of amphotericin B or one of its liposomal derivatives, is the usual treatment for invasive fungal infections, due to lack of a safe,…”
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Evaluation of Mycograb®, amphotericin B, caspofungin, and fluconazole in combination against Cryptococcus neoformans by checkerboard and time-kill methodologies by Nooney, Lucy, Matthews, Ruth C., Burnie, James P.

“…This article reported the identification of heat shock protein 90 (hsp90) homologues by immunoblot in Cryptococcus neoformans. Mycograb®, a genetically…”
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Human recombinant antibody to HSP90: a natural partner in combination therapy by Matthews, R C, Burnie, J P

“…Recent years have seen the development of the concept of combination therapy for treating severe fungal sepsis. The advantages of this approach are a potential…”
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Bordetella pertussis infection : Pathogenesis, diagnosis, management, and the role of protective immunity by KERR, J. R, MATTHEWS, R. C

“…Whooping cough is presently one of the ten most common causes of death from infectious disease worldwide. Despite a high vaccine uptake, resurgences of this…”
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Identification of an immunodominant ABC transporter in methicillin-resistant Staphylococcus aureus infections by BURNIE, J. P, MATTHEWS, R. C, CARTER, T, BEAULIEU, E, DONOHOE, M, CHAPMAN, C, WILLIAMSON, P, HODGETTS, S. J

“…Immunoblotting sera from 26 patients with septicemia due to an epidemic strain of methicillin-resistant Staphylococcus aureus (EMRSA-15), 6 of whom died,…”
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Bordetella pertussis surveillance in England and Wales: 1995–7 by VAN BUYNDER, P. G., OWEN, D., VURDIEN, J. E., ANDREWS, N. J., MATTHEWS, R. C., MILLER, E.

“…Available data sources on disease due to Bordetella pertussis, including notifications, hospital admissions, deaths, and an enhanced laboratory-based…”
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An epidemiological study of blood culture isolates of coagulase-negative staphylococci demonstrating hospital-acquired infection by BURNIE, J. P, NADERI-NASAB, M, LOUDON, K. W, MATTHEWS, R. C

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Identification of an immunodominant drug efflux pump in Burkholderia cepacia by Wigfield, S. M., Rigg, G. P., Kavari, M., Webb, A. K., Matthews, R. C., Burnie, J. P.

“…Burkholderia cepacia, a major pathogen amongst individuals with cystic fibrosis (CF), is intrinsically resistant to most clinically available antibiotics. We…”
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Pathogenicity determinants of Candida albicans : potential targets for immunotherapy ? by MATTHEWS, R. C

“…There are two synergistic approaches to the development of a new generation of antifungal agents. The first involves a better understanding of the pathogenesis…”
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The efficacy of acquired humoral and cellular immunity in the prevention and therapy of experimental fungal infections by Polonelli, L., Casadevall, A., Han, Y., Bernardis, F., Kirkland, T. N., Matthews, R. C., Adriani, D., Boccanera, M., Burnie, J. P., Cassone, A., Conti, S., Cutler, J. E., Frazzi, R., Gregory, C., Hodgetts, S., Illidge, C., Magliani, W., Rigg, G., Santoni, G.

“…In the past two decades, numerous studies have documented the importance of acquired immunity for host defense against invasive fungal infections. There is…”
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Application of polymerase chain reaction to fingerprinting Aspergillus fumigatus by random amplification of polymorphic DNA by LOUDON, K. W, BURNIE, J. P, COKE, A. P, MATTHEWS, R. C

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Autoantibody to heat-shock protein 90 can mediate protection against systemic candidosis by MATTHEWS, R. C, BURNIE, J. P, HOWAT, D, ROWLAND, T, WALTON, F

“…Epitope mapping shows that patients recovering from systemic infection with Candida albicans produce antibodies against both fungal-specific and conserved…”
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Quantification of Escherichia coli Genomic DNA Contamination in Recombinant Protein Preparations by Polymerase Chain Reaction and Affinity-Based Collection by Gregory, Carl A, Rigg, Gordon P, Illidge, Christopher M, Matthews, Ruth C

“…This study describes the development of a novel assay for the quantification of Escherichia coli genomic DNA contamination in recombinant protein samples. The…”
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Application of the polymerase chain reaction to the diagnosis of candidosis by amplification of an HSP 90 gene fragment by Crampin, A. C, Matthews, R. C

“…Department of Medical Microbiology, Manchester University Medical School, Oxford Road, Manchester M13 9PT * Correspondence should be sent to Dr R. C. Matthews…”
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Surveillance of whooping cough should continue by Matthews, Ruth C, Preston, Noel W, Holden, Debbie J

“…[...]if the organism cannot be cultured from mild infections in older children and adults, these atypical cases are unlikely to be a serious source of…”
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Semiquantitative polymerase chain reaction enzyme immunoassay for diagnosis of disseminated candidiasis by BURNIE, J. P, GOLBANG, N, MATTHEWS, R. C

“…A polymerase chain reaction enzyme immunoassay (PCR-EIA) was developed for the semiquantitative of circulating candidal DNA in disseminated candidiasis due to…”
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Early diagnosis of systemic candidal infection by Matthews, R C

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Immunoblot analysis of the serological response in systemic candidosis by Matthews, R C, Burnie, J P, Tabaqchali, S

“…To investigate the heterogeneity in antibody response to the various antigenic determinants of Candida albicans in patients with disseminated candidosis 201…”
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