Search Results - "Matthews, Jacqueline M"

GATA2 is required for lymphatic vessel valve development and maintenance by Kazenwadel, Jan, Betterman, Kelly L, Chong, Chan-Eng, Stokes, Philippa H, Lee, Young K, Secker, Genevieve A, Agalarov, Yan, Demir, Cansaran Saygili, Lawrence, David M, Sutton, Drew L, Tabruyn, Sebastien P, Miura, Naoyuki, Salminen, Marjo, Petrova, Tatiana V, Matthews, Jacqueline M, Hahn, Christopher N, Scott, Hamish S, Harvey, Natasha L

“…Heterozygous germline mutations in the zinc finger transcription factor GATA2 have recently been shown to underlie a range of clinical phenotypes, including…”
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Mutations in MITF and PAX3 cause "splashed white" and other white spotting phenotypes in horses by Hauswirth, Regula, Haase, Bianca, Blatter, Marlis, Brooks, Samantha A, Burger, Dominik, Drögemüller, Cord, Gerber, Vincent, Henke, Diana, Janda, Jozef, Jude, Rony, Magdesian, K Gary, Matthews, Jacqueline M, Poncet, Pierre-André, Svansson, Vilhjálmur, Tozaki, Teruaki, Wilkinson-White, Lorna, Penedo, M Cecilia T, Rieder, Stefan, Leeb, Tosso

“…During fetal development neural-crest-derived melanoblasts migrate across the entire body surface and differentiate into melanocytes, the pigment-producing…”
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The power of two: protein dimerization in biology by Marianayagam, Neelan J., Sunde, Margaret, Matthews, Jacqueline M.

“…The self-association of proteins to form dimers and higher-order oligomers is a very common phenomenon. Recent structural and biophysical studies show that…”
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Cyclic peptides can engage a single binding pocket through highly divergent modes by Patel, Karishma, Walport, Louise J., Walshe, James L., Solomon, Paul D., Low, Jason K. K., Tran, Daniel H., Mouradian, Kevork S., Silva, Ana P. G., Wilkinson-White, Lorna, Norman, Alexander, Franck, Charlotte, Matthews, Jacqueline M., Guss, J. Mitchell, Payne, Richard J., Passioura, Toby, Suga, Hiroaki, Mackay, Joel P.

“…Cyclic peptide library screening technologies show immense promise for identifying drug leads and chemical probes for challenging targets. However, the…”
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Discovery, characterization and in vivo activity of pyocin SD2, a protein antibiotic from Pseudomonas aeruginosa by McCaughey, Laura C, Josts, Inokentijs, Grinter, Rhys, White, Paul, Byron, Olwyn, Tucker, Nicholas P, Matthews, Jacqueline M, Kleanthous, Colin, Whitchurch, Cynthia B, Walker, Daniel

“…Increasing rates of antibiotic resistance among Gram-negative pathogens such as Pseudomonas aeruginosa means alternative approaches to antibiotic development…”
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Total Synthesis of Homogeneous Antifreeze Glycopeptides and Glycoproteins by Wilkinson, Brendan L., Stone, Robin S., Capicciotti, Chantelle J., Thaysen-Andersen, Morten, Matthews, Jacqueline M., Packer, Nicolle H., Ben, Robert N., Payne, Richard J.

“…Don't freeze! A native chemical ligation–desulfurization strategy has been employed for the convergent synthesis of a library of defined antifreeze…”
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Disparate binding kinetics by an intrinsically disordered domain enables temporal regulation of transcriptional complex formation by Robertson, Neil O., Smith, Ngaio C., Manakas, Athina, Mahjoub, Mahiar, McDonald, Gordon, Kwan, Ann H., Matthews, Jacqueline M.

“…Intrinsically disordered regions are highly represented among mammalian transcription factors, where they often contribute to the formation of multiprotein…”
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Zinc Fingers‐‐Folds for Many Occasions by Matthews, Jacqueline M., Sunde, Margaret

“…Zinc finger domains (ZnFs) are common, relatively small protein motifs that fold around one or more zinc ions. In addition to their role as a DNA‐binding…”
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1D Self‐Assembly and Ice Recrystallization Inhibition Activity of Antifreeze Glycopeptide‐Functionalized Perylene Bisimides by Adam, Madeleine K., Jarrett‐Wilkins, Charles, Beards, Michael, Staykov, Emiliyan, MacFarlane, Liam R., Bell, Toby D. M., Matthews, Jacqueline M., Manners, Ian, Faul, Charl F. J., Moens, Pierre D. J., Ben, Robert N., Wilkinson, Brendan L.

“…Antifreeze glycoproteins (AFGPs) are polymeric natural products that have drawn considerable interest in diverse research fields owing to their potent ice…”
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Correction: Mutations in MITF and PAX3 Cause "Splashed White" and Other White Spotting Phenotypes in Horses by Hauswirth, Regula, Haase, Bianca, Blatter, Marlis, Brooks, Samantha A, Burger, Dominik, Drögemüller, Cord, Gerber, Vincent, Henke, Diana, Janda, Jozef, Jude, Rony, Magdesian, K Gary, Matthews, Jacqueline M, Poncet, Pierre-André, Svansson, Vilhjálmur, Tozaki, Teruaki, Wilkinson-White, Lorna, Penedo, M Cecilia T, Rieder, Stefan, Leeb, Tosso

“…[This corrects the article DOI: 10.1371/journal.pgen.1002653.]…”
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Mechanism of allosteric regulation of transglutaminase 2 by GTP by Begg, Gillian E, Carrington, Lyle, Stokes, Philippa H, Matthews, Jacqueline M, Wouters, Merridee A, Husain, Ahsan, Lorand, Laszlo, Iismaa, Siiri E, Graham, Robert M

“…Allosteric regulation is a fundamental mechanism of biological control. Here, we investigated the allosteric mechanism by which GTP inhibits cross-linking…”
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TNP Analogues Inhibit the Virulence Promoting IP3-4 Kinase Arg1 in the Fungal Pathogen Cryptococcus neoformans by Desmarini, Desmarini, Truong, Daniel, Wilkinson-White, Lorna, Desphande, Chandrika, Torrado, Mario, Mackay, Joel P., Matthews, Jacqueline M., Sorrell, Tania C., Lev, Sophie, Thompson, Philip E., Djordjevic, Julianne Teresa

“…New antifungals with unique modes of action are urgently needed to treat the increasing global burden of invasive fungal infections. The fungal inositol…”
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Structural Basis for Partial Redundancy in a Class of Transcription Factors, the LIM Homeodomain Proteins, in Neural Cell Type Specification by Gadd, Morgan S., Bhati, Mugdha, Jeffries, Cy M., Langley, David B., Trewhella, Jill, Guss, J. Mitchell, Matthews, Jacqueline M.

“…Combinations of LIM homeodomain proteins form a transcriptional “LIM code” to direct the specification of neural cell types. Two paralogous pairs of LIM…”
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Interactions between LHX3- and ISL1-family LIM-homeodomain transcription factors are conserved in Caenorhabditis elegans by Bhati, Mugdha, Llamosas, Estelle, Jacques, David A., Jeffries, Cy M., Dastmalchi, Siavoush, Ripin, Nina, Nicholas, Hannah R., Matthews, Jacqueline M.

“…LIM-Homeodomain (LIM-HD) transcription factors are highly conserved in animals where they are thought to act in a transcriptional ‘LIM code’ that specifies…”
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Structural basis of simultaneous recruitment of the transcriptional regulators LMO2 and FOG1/ZFPM1 by the transcription factor GATA1 by Wilkinson-White, Lorna, Gamsjaeger, Roland, Dastmalchi, Siavoush, Wienert, Beeke, Stokes, Philippa H, Crossley, Merlin, Mackay, Joel P, Matthews, Jacqueline M

“…The control of red blood cell and megakaryocyte development by the regulatory protein GATA1 is a paradigm for transcriptional regulation of gene expression in…”
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A Structural Basis for the Regulation of the LIM-Homeodomain Protein Islet 1 (Isl1) by Intra- and Intermolecular Interactions by Gadd, Morgan S., Jacques, David A., Nisevic, Ivan, Craig, Vanessa J., Kwan, Ann H., Guss, J. Mitchell, Matthews, Jacqueline M.

“…Islet 1 (Isl1) is a transcription factor of the LIM-homeodomain (LIM-HD) protein family and is essential for many developmental processes. LIM-HD proteins all…”
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Contribution of DEAF1 structural domains to the interaction with the breast cancer oncogene LMO4 by Cubeddu, Liza, Joseph, Soumya, Richard, Derek J, Matthews, Jacqueline M

“…The proteins LMO4 and DEAF1 contribute to the proliferation of mammary epithelial cells. During breast cancer LMO4 is upregulated, affecting its interaction…”
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Implementing the LIM code: the structural basis for cell type-specific assembly of LIM-homeodomain complexes by Bhati, Mugdha, Lee, Christopher, Nancarrow, Amy L, Lee, Mihwa, Craig, Vanessa J, Bach, Ingolf, Guss, J Mitchell, Mackay, Joel P, Matthews, Jacqueline M

“…LIM‐homeodomain (LIM‐HD) transcription factors form a combinatorial ‘LIM code’ that contributes to the specification of cell types. In the ventral spinal cord,…”
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The structure of an LIM-only protein 4 (LMO4) and Deformed epidermal autoregulatory factor-1 (DEAF1) complex reveals a common mode of binding to LMO4 by Joseph, Soumya, Kwan, Ann H, Stokes, Philippa H, Mackay, Joel P, Cubeddu, Liza, Matthews, Jacqueline M

“…LIM-domain only protein 4 (LMO4) is a widely expressed protein with important roles in embryonic development and breast cancer. It has been reported to bind…”
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The importance of pH in regulating the function of the Fasciola hepatica cathepsin L1 cysteine protease by Lowther, Jonathan, Robinson, Mark W, Donnelly, Sheila M, Xu, Weibo, Stack, Colin M, Matthews, Jacqueline M, Dalton, John P

“…The helminth parasite Fasciola hepatica secretes cathepsin L cysteine proteases to invade its host, migrate through tissues and digest haemoglobin, its main…”
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