Search Results - "Matthews, Clayton A."

Clinical, Pharmacodynamic, and Pharmacokinetic Evaluation of BNC105P: A Phase I Trial of a Novel Vascular Disrupting Agent and Inhibitor of Cancer Cell Proliferation by RISCHIN, Danny, BIBBY, David C, CHONG, Geoff, KREMMIDIOTIS, Gabriel, LESKE, Annabell F, MATTHEWS, ClaytonA, WONG, ShirleyS, ROSEN, Mark A, DESAI, Jayesh

“…To determine the recommended phase II dose and evaluate the safety and toxicity profile and pharmacokinetic (PK) and pharmacodynamic (PD) effects of BNC105P,…”
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BNC105: a novel tubulin polymerization inhibitor that selectively disrupts tumor vasculature and displays single-agent antitumor efficacy by Kremmidiotis, Gabriel, Leske, Annabell F, Lavranos, Tina C, Beaumont, Donna, Gasic, Jelena, Hall, Allison, O'Callaghan, Michael, Matthews, Clayton A, Flynn, Bernard

“…Vascular disruption agents (VDA) cause occlusion of tumor vasculature, resulting in hypoxia-driven tumor cell necrosis. Tumor vascular disruption is a…”
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Expression and evolution of the mammalian brain gene Ttyh1 by Matthews, Clayton A., Shaw, John E., Hooper, Jane A., Young, Ian G., Crouch, Michael F., Campbell, Hugh D.

“…Homologues of the Drosophila melanogaster tweety (tty) gene are present in mammals and Caenorhabditis elegans. The encoded proteins have five predicted…”
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Multinomial Logistic Regression by Kwak, Chanyeong, Clayton-Matthews, Alan

“…BACKGROUNDWhen the dependent variable consists of several categories that are not ordinal (i.e., they have no natural ordering), the ordinary least square…”
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Consistent Economic Indexes for the 50 States by Crone, Theodore M., Clayton-Matthews, Alan

“…In the late 1980s James Stock and Mark Watson developed for the U.S. economy an alternative coincident index to the one now published by the Conference Board…”
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Abstract 2768: Development of a tubulin fractionation assay for the evaluation of “on target” activity of tubulin targeting agents in clinical PBMC samples by Matthews, Clayton A., Bibby, David, Leske, Annabell F., Harvey, Andrew J., Kremmidiotis, Gabriel

“…The novel agent, BNC105, is a tubulin polymerization inhibitor which acts as a vascular disruption agent (VDA). BNC105 exhibits 100-fold selectivity for…”
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Abstract 2498: BNC105 is a tubulin polymerization inhibitor that exhibits vascular disruptive activity in renal cancer and causes upregulation in HIF1alpha, HIF2alpha and mTOR by Leske, Annabell F., Beaumont, Donna M., Lavranos, Tina C., Gasic, Jelena, Coles, Carolyn J., Matthews, Clayton A., Phillips, Renee J., Kremmidiotis, Gabriel

“…BNC105 is a tubulin polymerization inhibitor. This agent selectively disrupts the vasculature in tumors, and in addition acts as a direct cytotoxic against…”
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The differential importance of weight and body image among college men and women by Hesse-Biber, S, Clayton-Matthews, A, Downey, J A

“…Among a sample of American college students, body image and the degree of desired weight change were associated with academic self-rankings, with social and…”
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