Search Results - "Matthew S. Bogdanffy"

Nonclinical Safety of the Sodium-Glucose Cotransporter 2 Inhibitor Empagliflozin by Bogdanffy, Matthew S., Stachlewitz, Robert F., van Tongeren, Susan, Knight, Brian, Sharp, Dale E., Ku, Warren, Hart, Susan Emeigh, Blanchard, Kerry

“…Empagliflozin, a selective inhibitor of the renal tubular sodium-glucose cotransporter 2, was developed for treatment of type 2 diabetes mellitus. Nonclinical…”
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Mode of action and human relevance assessment of male CD‐1 mouse renal adenocarcinoma associated with lifetime exposure to empagliflozin by Phillips, Jonathan A., Taub, Mitchell E., Bogdanffy, Matthew S., Yuan, Jing, Knight, Brian, Smith, James D., Ku, Warren W.

“…Inhibition of sodium‐glucose cotransporter‐2 (SGLT2) has been shown to be a safe and efficacious approach to support managing Type 2 diabetes. In the 2‐year…”
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Current nonclinical testing paradigms in support of safe clinical trials: An IQ Consortium DruSafe perspective by Butler, Lynne D., Guzzie-Peck, Peggy, Hartke, James, Bogdanffy, Matthew S., Will, Yvonne, Diaz, Dolores, Mortimer-Cassen, Elisabeth, Derzi, Mazin, Greene, Nigel, DeGeorge, Joseph J.

“…The transition from nonclinical to First-in-Human (FIH) testing is one of the most challenging steps in drug development. In response to serious outcomes in a…”
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Tg.rasH2 Mouse Model for Assessing Carcinogenic Potential of Pharmaceuticals: Industry Survey of Current Practices by Bogdanffy, Matthew S., Lesniak, Jacob, Mangipudy, Raja, Sistare, Frank D., Colman, Karyn, Garcia-Tapia, David, Monticello, Thomas, Blanset, Diann

“…The Tg.rasH2 mouse was developed as an alternative model to the traditional 2-year mouse bioassay for pharmaceutical carcinogenicity testing. This model has…”
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Featured Cover by Phillips, Jonathan A., Taub, Mitchell E., Bogdanffy, Matthew S., Yuan, Jing, Knight, Brian, Smith, James D., Ku, Warren W.

“…The cover image is based on the Hypothesis Mode of action and human relevance assessment of male CD‐1 mouse renal adenocarcinoma associated with lifetime…”
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Differentiating between local cytotoxicity, mitogenesis, and genotoxicity in carcinogen risk assessments: the case of vinyl acetate by Bogdanffy, Matthew S., Valentine, Rudolph

“…Understanding the mode of action of carcinogens is critical to scientifically assessing exposure-related risk. Regulatory hazard classification schemes and…”
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Dose-dependent transitions in mechanisms of toxicity: case studies by Slikker, William, Andersen, Melvin E., Bogdanffy, Matthew S., Bus, James S., Cohen, Steven D., Conolly, Rory B., David, Raymond M., Doerrer, Nancy G., Dorman, David C., Gaylor, David W., Hattis, Dale, Rogers, John M., Setzer, R. Woodrow, Swenberg, James A., Wallace, Kendall

“…Experience with dose response and mechanisms of toxicity has shown that multiple mechanisms may exist for a single agent along the continuum of the full…”
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Dose-dependent transitions in mechanisms of toxicity by Slikker, William, Andersen, Melvin E., Bogdanffy, Matthew S., Bus, James S., Cohen, Steven D., Conolly, Rory B., David, Raymond M., Doerrer, Nancy G., Dorman, David C., Gaylor, David W., Hattis, Dale, Rogers, John M., Woodrow Setzer, R., Swenberg, James A., Wallace, Kendall

“…Scientists and decision makers from all sectors agree that risk assessments should be based on the best available science. Several years ago, the Health and…”
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A PBPK Model for Evaluating the Impact of Aldehyde Dehydrogenase Polymorphisms on Comparative Rat and Human Nasal Tissue Acetaldehyde Dosimetry by Teeguarden, Justin G., Bogdanffy, Matthew S., Covington, Tammie R., Tan, Cecilia, Jarabek, Annie M.

“…Acetaldehyde is an important intermediate in the chemical synthesis and normal oxidative metabolism of several industrially important compounds, including…”
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CHRONIC TOXICITY AND ONCOGENICITY BIOASSAY IN RATS WITH THE CHLORO-s-TRIAZINE HERBICIDE CYANAZINE by Bogdanffy, M S, O'Connor, J C, Hansen, J F, Gaddamidi, V, Van Pelt, C S, Green, J W, Cook, J C

“…Cyanazine is a member of the chloro-s-triazine class of herbicides. Other triazine herbicides have been shown to induce mammary-gland tumors in rats, although…”
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HIGH-AFFINITY NASAL EXTRACTION OF VINYL ACETATE VAPOR IS CARBOXYLESTERASE DEPENDENT by Bogdanffy, M S, Manning, L A, Sarangapani, R

“…Vinyl acetate induces nasal tumors in rats, but not mice. Species differences in airflow patterns, physiology, and biochemistry complicate extrapolation of…”
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FOUR-WEEK INHALATION CELL PROLIFERATION STUDY OF THE EFFECTS OF VINYL ACETATE ON RAT NASAL EPITHELIUM by Bogdanffy, Matthew S., Gladnick, N. Larry, Kegelman, Thomas, Frame, S. Randall

“…Inhalation exposure of rats to 600 ppm vinyl acetate monomer produced nasal papillomas, squamous-cell carcinomas, and carcinoma in situ in rats. These tumors…”
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MODE-OF-ACTION?BASED DOSIMETERS FOR INTERSPECIES EXTRAPOLATION OF VINYL ACETATE INHALATION RISK by Bogdanffy, M S, Plowchalk, D R, Sarangapani, R, Starr, T B, Andersen, M E

“…Vinyl acetate is used in the manufacture of many polymers. The Clean Air Act Amendments of 1990 require that an inhalation risk assessment be conducted to…”
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Evaluation of Effects from Repeated Inhalation Exposure of F344 Rats to High Concentrations of Propylene by Pottenger, Lynn H., Malley, Linda A., Bogdanffy, Matthew S., Donner, E. Maria, Upton, Patricia B., Li, Yutai, Walker, Vernon E., Harkema, Jack R., Banton, Marcy I., Swenberg, James A.

“…Chronic exposure to propylene does not result in any increased incidence of tumors, yet does increase N7-hydroxypropylguanine (N7-HPGua) adducts in tissue DNA…”
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Vinyl Acetate-Induced Intracellular Acidification: Implications for Risk Assessment by BOGDANFFY, Matthew S

“…Cancerbioassays have demonstrated the carcinogenic activity of vinyl acetate in rodents. Tumors appear only at the site of contact and mechanistic data suggest…”
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Vinyl Acetate Decreases Intracellular pH in Rat Nasal Epithelial Cells by Lantz, R. Clark, Orozco, Jason, Bogdanffy, Matthew S.

“…Vinyl acetate is a synthetic organic ester that has been shown to produce nasal tumors in rats following exposure to 600 ppm in air. The proposed mechanism of…”
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Physiologically-based kinetic modeling of vapours toxic to the respiratory tract by Bogdanffy, Matthew S, Sarangapani, Ramesh

“…The respiratory tract is frequently identified as a site of toxicity for inhaled xenobiotic chemicals. Usually, these observations come from controlled animal…”
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Vinyl acetate induces intracellular acidification in mouse oral buccal epithelial cells by Nakamoto, Tetsuji, Wagner, Mark, Melvin, James E., Bogdanffy, Matthew S.

“…Vinyl acetate exposure in drinking water has been associated with tumor formation in the upper gastrointestinal tract of rats and mice. One potential mechanism…”
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Harmonization of Cancer and Noncancer Risk assessment : Proceedings of a consensus-building workshop by BOGDANFFY, Matthew S, DASTON, George, FAUSTMAN, Elaine M, KIMMEL, Carole A, KIMMEL, Gary L, SEED, Jennifer, VU, Vanessa

“…Significant advancements have been made toward the use of all relevant scientific information in health risk assessments. This principle has been set forth in…”
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Nasal lesion development and reversibility in rats exposed to aerosols of dibasic esters by Lee, K P, Valentine, R, Bogdanffy, M S

“…This study was conducted to investigate the initial tissue damage, morphogenesis, and reversibility of nasal lesions induced by the inhalation of dibasic…”
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