Search Results - "Matthew, William D."

Impairment of the Blood–Nerve and Blood–Brain Barriers in Apolipoprotein E Knockout Mice by Fullerton, Stephanie M., Shirman, Gregory A., Strittmatter, Warren J., Matthew, William D.

“…Apolipoprotein E (apoE) is well characterized as a plasma lipoprotein involved in lipid and cholesterol metabolism. Recent studies implicating apoE in…”
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Glial Growth Factor 2, a Soluble Neuregulin, Directly Increases Schwann Cell Motility and Indirectly Promotes Neurite Outgrowth by Mahanthappa, Nagesh K, Anton, Eva S, Matthew, William D

“…Schwann cells proliferate, migrate, and act as sources of neurotrophic support during development and regeneration of peripheral nerves. Recent studies have…”
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Nerve Growth Factor and Its Low-Affinity Receptor Promote Schwann Cell Migration by Anton, Eva S., Weskamp, Gisela, Reichardt, Louis F., Matthew, William D.

“…Migrating Schwann cells in developing or regenerating peripheral nerves are known to express dramatically increased levels of nerve growth factor (NGF) and the…”
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Apolipoprotein E Binds to and Potentiates the Biological Activity of Ciliary Neurotrophic Factor by Gutman, Catherine R, Strittmatter, Warren J, Weisgraber, Karl H, Matthew, William D

“…Expression of apolipoprotein E (apoE) and ciliary neurotrophic factor (CNTF), a pleiotropic neuron survival factor, increases in the CNS in response to injury…”
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Endogenous apolipoprotein E suppresses LPS-stimulated microglial nitric oxide production by Laskowitz, Daniel T, Matthew, William D, Bennett, Ellen R, Schmechel, Donald, Herbstreith, Michael H, Goel, Sanjay, McMillian, Michael K

“…THE human apolipoprotein (apo) E4 isoform is associated with an increased risk for Alzheimerʼs disease (AD) and poor prognosis after acute CNS injury. Addition…”
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An in Vitro Neurite-Promoting Antigen Functions in Axonal Regeneration in vivo by Sandrock, Alfred W., Matthew, William D.

“…The function of the neurite growth-promoting antigen INO has been tested in an in vivo neurite regeneration system, the rat iris. The sympathetic innervation…”
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CD9 plays a role in Schwann cell migration in vitro by Anton, ES, Hadjiargyrou, M, Patterson, PH, Matthew, WD

“…To identify molecules that regulate Schwann cell migration, we have generated a panel of monoclonal antibodies against Schwann cell surface antigens that…”
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Peripheral Sensory Nerve Defects in Apolipoprotein E Knockout Mice by Fullerton, Stephanie M., Strittmatter, Warren J., Matthew, William D.

“…Apolipoprotein E (apoE), a plasma lipoprotein involved in lipid metabolism, is also proposed to have important functions within the central and peripheral…”
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Merosin Promotes Neurite Growth and Schwann Cell Migration in Vitro and Nerve Regeneration in Vivo: Evidence Using an Antibody to Merosin, ARM-1 by Anton, Eva S., Sandrock, Alfred W., Matthew, William D.

“…Monoclonal antibodies that block the cellular function(s) of specific antigens can provide valuable probes for in vitro and in vivo bioassays. With the goal of…”
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Botulinum Toxin in the Treatment of Facial Paralysis by Mehdizadeh, Omid B., MD, Diels, Jacqueline, OT, White, William Matthew, MD

“…This article reviews the current literature supporting the use of botulinum toxin in producing symmetric facial features and reducing unwanted, involuntary…”
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Interaction of Apolipoprotein E with Laminin Increases Neuronal Adhesion and Alters Neurite Morphology by Huang, David Y., Weisgraber, Karl H., Strittmatter, Warren J., Matthew, William D.

“…The extracellular matrix protein laminin profoundly affects neuronal adhesion, spreading, differentiation, and growth by binding integrin-type cell surface…”
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Neurotrophins affect the pattern of DRG neurite growth in a bioassay that presents a choice of CNS and PNS substrates by Tuttle, R, Matthew, W D

“…Neurons can be categorized in terms of where their axons project: within the central nervous system, within the peripheral nervous system, or through both…”
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Identification of a Synaptic Vesicle-Specific Membrane Protein with a Wide Distribution in Neuronal and Neurosecretory Tissue by Matthew, William D., Tsavaler, Larisa, Reichardt, Louis F.

“…Two different monoclonal antibodies, characterized initially as binding synaptic terminal regions of rat brain, bind a 65,000-dalton protein, which is exposed…”
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Neurite Outgrowth Is Enhanced by Anti-Idiotypic Monoclonal Antibodies to the Ganglioside GM1 by Riggott, Marcia J., Matthew, William D.

“…Exogenously added gangliosides enhance sprouting, neurite outgrowth, and other neuronal activities; this effect may be initiated when a ganglioside binds to a…”
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Anti-idiotypic monoclonal antibodies to GM1 identify ganglioside binding proteins by Riggott, Marcia J., Matthew, William D.

“…Ganglioside stimulated neurite outgrowth may be due to ganglioside binding to membrane proteins or to intercalation into the membrane. To test that ganglioside…”
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Cyclophosphamide treatment used to manipulate the immune response for the production of monoclonal antibodies by Matthew, W D, Sandrock, Jr, A W

“…After immunization with a complex mixture of antigens, a considerable bias toward obtaining monoclonal antibodies to immunodominant determinants exists. By…”
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Generating monoclonal antibodies to neuronal antigens by Riggott, Marcia J., Matthew, William D.

“…Methods for generating monoclonal antibodies directed to the functional sites of neuronal antigens are reviewed. These methods include optimal antigen…”
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An in vitro bioassay for neurite growth using cryostat sections of nervous tissue as a substratum by Tuttle, R, Matthew, W D

“…An in vitro bioassay is described that can be used for studying neurite growth, cell adhesion, and cell migration, as well as other cellular behaviors. The…”
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A Monoclonal Antibody That Blocks the Activity of a Neurite Regeneration-Promoting Factor: Studies on the Binding Site and Its Localization in vivo by Chiu, Arlene Y., Matthew, William D., Patterson, Paul H.

“…Work from several laboratories has identified a proteoglycan complex secreted by a variety of non-neuronal cells that can promote neurite regeneration when…”
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Identification of a Peripheral Nerve Neurite Growth-Promoting Activity by Development and Use of an in vitro Bioassay by Sandrock, Alfred W., Matthew, William D.

“…The effective regeneration of severed neuronal axons in the peripheral nerves of adult mammals may be explained by the presence of molecules in situ that…”
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