Search Results - "Matthes, Susann"

Depletion of angiotensin-converting enzyme 2 reduces brain serotonin and impairs the running-induced neurogenic response by Klempin, Friederike, Mosienko, Valentina, Matthes, Susann, Villela, Daniel C., Todiras, Mihail, Penninger, Josef M., Bader, Michael, Santos, Robson A. S., Alenina, Natalia

“…Physical exercise induces cell proliferation in the adult hippocampus in rodents. Serotonin (5-HT) and angiotensin (Ang) II are important mediators of the…”
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Lrp5 functions in bone to regulate bone mass by Cui, Yajun, Niziolek, Paul J, MacDonald, Bryan T, Zylstra, Cassandra R, Alenina, Natalia, Robinson, Daniel R, Zhong, Zhendong, Matthes, Susann, Jacobsen, Christina M, Conlon, Ronald A, Brommage, Robert, Liu, Qingyun, Mseeh, Faika, Powell, David R, Yang, Qi M, Zambrowicz, Brian, Gerrits, Han, Gossen, Jan A, He, Xi, Bader, Michael, Williams, Bart O, Warman, Matthew L, Robling, Alexander G

“…Mutations in the Wnt co-receptor, LRP5 , lead to skeletal diseases in humans. Matthew Warman and his colleagues have now developed mutant mice with…”
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Enduring Effects of Conditional Brain Serotonin Knockdown, Followed by Recovery, on Adult Rat Neurogenesis and Behavior by Sidorova, Maria, Kronenberg, Golo, Matthes, Susann, Petermann, Markus, Hellweg, Rainer, Tuchina, Oksana, Bader, Michael, Alenina, Natalia, Klempin, Friederike

“…Serotonin (5-hydroxytryptamine, 5-HT) is a crucial signal in the neurogenic niche of the hippocampus, where it is involved in antidepressant action. Here, we…”
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Peripheral Serotonin Synthesis as a New Drug Target by Matthes, Susann, Bader, Michael

“…The first step in serotonin (5-HT) biosynthesis is catalyzed by tryptophan hydroxylase (TPH). There are two independent sources of the monoamine that have…”
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Life without brain serotonin: Reevaluation of serotonin function with mice deficient in brain serotonin synthesis by Mosienko, Valentina, Beis, Daniel, Pasqualetti, Massimo, Waider, Jonas, Matthes, Susann, Qadri, Fatimunnisa, Bader, Michael, Alenina, Natalia

“…•Tph2−/− mouse is an animal model depleted of the neurotransmitter serotonin.•In this review we critically discuss the recent data obtained from Tph2−/−…”
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Structure-Based Design of Xanthine-Imidazopyridines and -Imidazothiazoles as Highly Potent and In Vivo Efficacious Tryptophan Hydroxylase Inhibitors by Specker, Edgar, Wesolowski, Radoslaw, Schütz, Anja, Matthes, Susann, Mallow, Keven, Wasinska-Kalwa, Malgorzata, Winkler, Lars, Oder, Andreas, Alenina, Natalia, Pleimes, Dirk, von Kries, Jens Peter, Heinemann, Udo, Bader, Michael, Nazaré, Marc

“…Tryptophan hydroxylases catalyze the first and rate-limiting step in the biosynthesis of serotonin, a well-known neurotransmitter that plays an important role…”
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Phenylalanine hydroxylase contributes to serotonin synthesis in mice by Mordhorst, Alexander, Dhandapani, Priyavathi, Matthes, Susann, Mosienko, Valentina, Rothe, Michael, Todiras, Mihail, Self, Julie, Schunck, Wolf‐Hagen, Schütz, Anja, Bader, Michael, Alenina, Natalia

“…Serotonin is an important signaling molecule in the periphery and in the brain. The hydroxylation of tryptophan is the first and rate‐limiting step of its…”
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Structure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors by Specker, Edgar, Matthes, Susann, Wesolowski, Radoslaw, Schütz, Anja, Grohmann, Maik, Alenina, Natalia, Pleimes, Dirk, Mallow, Keven, Neuenschwander, Martin, Gogolin, Angelina, Weise, Marie, Pfeifer, Jochen, Ziebart, Nandor, Heinemann, Udo, von Kries, Jens Peter, Nazaré, Marc, Bader, Michael

“…Tryptophan hydroxylases catalyze the first and rate-limiting step in the synthesis of serotonin. Serotonin is a key neurotransmitter in the central nervous…”
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Targeted Manipulation of Brain Serotonin: RNAi-Mediated Knockdown of Tryptophan Hydroxylase 2 in Rats by Matthes, Susann, Mosienko, Valentina, Popova, Elena, Rivalan, Marion, Bader, Michael, Alenina, Natalia

“…Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the biosynthesis of the biogenic monoamine serotonin (5-hydroxytryptamine, 5-HT). Two existing TPH…”
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Adaptive changes in serotonin metabolism preserve normal behavior in mice with reduced TPH2 activity by Mosienko, Valentina, Matthes, Susann, Hirth, Natalie, Beis, Daniel, Flinders, Michael, Bader, Michael, Hansson, Anita C., Alenina, Natalia

“…Polymorphisms in the TPH2 gene coding for the serotonin synthesizing enzyme in the brain are considered as risk factors associated with depression and anxiety…”
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Novel Tryptophan Hydroxylase Inhibitor TPT-001 Reverses PAH, Vascular Remodeling, and Proliferative-Proinflammatory Gene Expression by Legchenko, Ekaterina, Chouvarine, Philippe, Qadri, Fatimunnisa, Specker, Edgar, Nazaré, Marc, Wesolowski, Radoslaw, Matthes, Susann, Bader, Michael, Hansmann, Georg

“…[Display omitted] •Peripheral serotonin, synthesized by the enzyme TPH1, is a pathogenic factor in PAH.•Oral TPT-001, a novel class drug of TPHi, reverses…”
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Tryptophan hydroxylase as novel target for the treatment of depressive disorders by Matthes, Susann, Mosienko, Valentina, Bashammakh, Saleh, Alenina, Natalia, Bader, Michael

“…Serotonin (5-HT) is a monoamine implicated in a variety of physiological processes that functions either as a neurotransmitter or as a peripheral hormone…”
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Measurement of Plasma, Serum, and Platelet Serotonin in Individuals With High Bone Mass and Mutations in LRP5 by Lee, Grace S, Simpson, Christine, Sun, Ben‐Hua, Yao, Chen, Foer, Dinah, Sullivan, Becky, Matthes, Susann, Alenina, Natalia, Belsky, Joseph, Bader, Michael, Insogna, Karl L

“…ABSTRACT It has recently been suggested that the low‐density lipoprotein receptor‐related protein 5 (LRP5) regulates bone mass by suppressing secretion of…”
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Lrp5 regulation of bone mass and serotonin synthesis in the gut by Kode, Aruna, Obri, Arnaud, Paone, Riccardo, Kousteni, Stavroula, Ducy, Patricia, Karsenty, Gerard

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Reply to Lrp5 regulation of bone mass and gut serotonin synthesis by Cui, Yajun, Niziolek, Paul J, MacDonald, Bryan T, Alenina, Natalia, Matthes, Susann, Jacobsen, Christina M, Conlon, Ronald A, Brommage, Robert, Powell, David R, He, Xi, Bader, Michael, Williams, Bart O, Warman, Matthew L, Robling, Alexander G

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Community-Wide Experimental Evaluation of the PROSS Stability-Design Method by Peleg, Yoav, Vincentelli, Renaud, Collins, Brett M., Chen, Kai-En, Livingstone, Emma K., Weeratunga, Saroja, Leneva, Natalya, Guo, Qian, Remans, Kim, Perez, Kathryn, Bjerga, Gro E.K, Larsen, Øivind, Vaněk, Ondřej, Skořepa, Ondřej, Jacquemin, Sophie, Poterszman, Arnaud, Kjær, Svend, Christodoulou, Evangelos, Albeck, Shira, Dym, Orly, Ainbinder, Elena, Unger, Tamar, Schuetz, Anja, Matthes, Susann, Bader, Michael, de Marco, Ario, Storici, Paola, Semrau, Marta S., Stolt-Bergner, Peggy, Aigner, Christian, Suppmann, Sabine, Goldenzweig, Adi, Fleishman, Sarel J

“…[Display omitted] •PROSS can be implemented by protein scientists without a background in protein design.•PROSS designs showed improved expression and…”
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Warman et al. reply by Cui, Yajun, Niziolek, Paul J, MacDonald, Bryan T, Alenina, Natalia, Matthes, Susann, Jacobsen, Christina M, Conlon, Ronald A, Brommage, Robert, Powell, David R, He, Xi, Bader, Michael, Williams, Bart O, Warman, Matthew L, Robling, Alexander G

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