Decline in spontaneous activity of group A αβ sensory afferents after sciatic nerve axotomy in rat

Decline in spontaneous activity of group A αβ sensory afferents after sciatic nerve axotomy in rat

Changes are observed in the strength of central synaptic transmission and the firing behavior of primary afferents damaged by peripheral nerve injury. To clarify the relationship between synaptic strength and amount of spontaneous activity, firing behavior was studied in adult, male Sprague–Dawley r...

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Bibliographic Details
Published in:Neuroscience letters Vol. 274; no. 1; pp. 41 - 44
Main Authors: Seburn, Kevin L, Catlin, Pamela A, Dixon, Joel F, Lee, Ming H, Matteson, Melissa S, Cope, Timothy C
Format: Journal Article
Language:English
Published: Shannon Elsevier Ireland Ltd 15-10-1999
Elsevier
Subjects:
Axotomy
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ
Rat
Sciatic nerve
Sensation
Spontaneous activity
Synaptic transmission
Vertebrates: nervous system and sense organs
Sensation
Axotomy
Rat
Synaptic transmission
Spontaneous activity
Sciatic nerve
Peripheral nervous system
Vertebrata
Mammalia
Rodentia
Sensorial perception
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Summary:Changes are observed in the strength of central synaptic transmission and the firing behavior of primary afferents damaged by peripheral nerve injury. To clarify the relationship between synaptic strength and amount of spontaneous activity, firing behavior was studied in adult, male Sprague–Dawley rats in which sciatic nerve afferents were axotomized. Intra-axonal recordings were taken from A αβafferents within 7 h (acute, n=309), at 3 days ( n=228), or at 10 days ( n=230) after sciatic nerve cut. The proportion of spontaneously discharging afferents fell from 22% in the acute group to ≤13% in chronic groups. Thus, neither the progressive decline in the strength of central synaptic transmission from cut primary afferents nor the altered sensation observed after nerve cut can be explained by chronic changes in spontaneous activity of cut A α/Aβ afferents.
ISSN:0304-3940
1872-7972
DOI:10.1016/S0304-3940(99)00667-9