Search Results - "Mattern, Derek J."

Regulation and Role of Fungal Secondary Metabolites by Macheleidt, Juliane, Mattern, Derek J, Fischer, Juliane, Netzker, Tina, Weber, Jakob, Schroeckh, Volker, Valiante, Vito, Brakhage, Axel A

“…Fungi have the capability to produce a tremendous number of so-called secondary metabolites, which possess a multitude of functions, e.g., communication…”
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Microbial communication leading to the activation of silent fungal secondary metabolite gene clusters by Netzker, Tina, Fischer, Juliane, Weber, Jakob, Mattern, Derek J, König, Claudia C, Valiante, Vito, Schroeckh, Volker, Brakhage, Axel A

“…Microorganisms form diverse multispecies communities in various ecosystems. The high abundance of fungal and bacterial species in these consortia results in…”
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Bacillus subtilis attachment to Aspergillus niger hyphae results in mutually altered metabolism by Benoit, Isabelle, van den Esker, Marielle H., Patyshakuliyeva, Aleksandrina, Mattern, Derek J., Blei, Felix, Zhou, Miaomiao, Dijksterhuis, Jan, Brakhage, Axel A., Kuipers, Oscar P., de Vries, Ronald P., Kovács, Ákos T.

“…Summary Interaction between microbes affects the growth, metabolism and differentiation of members of the microbial community. While direct and indirect…”
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Virulence determinants of the human pathogenic fungus Aspergillus fumigatus protect against soil amoeba predation by Hillmann, Falk, Novohradská, Silvia, Mattern, Derek J., Forberger, Tilmann, Heinekamp, Thorsten, Westermann, Martin, Winckler, Thomas, Brakhage, Axel A.

“…Summary Filamentous fungi represent classical examples for environmentally acquired human pathogens whose major virulence mechanisms are likely to have emerged…”
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Synergistic activity of cosecreted natural products from amoebae-associated bacteria by Arp, Johannes, Götze, Sebastian, Mukherji, Ruchira, Mattern, Derek J., García-Altares, María, Klapper, Martin, Brock, Debra A., Brakhage, Axel A., Strassmann, Joan E., Queller, David C., Bardl, Bettina, Willing, Karsten, Peschel, Gundela, Stallforth, Pierre

“…Investigating microbial interactions from an ecological perspective is a particularly fruitful approach to unveil both new chemistry and bioactivity. Microbial…”
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Identification of the antiphagocytic trypacidin gene cluster in the human-pathogenic fungus Aspergillus fumigatus by Mattern, Derek J, Schoeler, Hanno, Weber, Jakob, Novohradská, Silvia, Kraibooj, Kaswara, Dahse, Hans-Martin, Hillmann, Falk, Valiante, Vito, Figge, Marc Thilo, Brakhage, Axel A

“…The opportunistic human pathogen Aspergillus fumigatus produces numerous different natural products. The genetic basis for the biosynthesis of a number of…”
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SCF Ubiquitin Ligase F-box Protein Fbx15 Controls Nuclear Co-repressor Localization, Stress Response and Virulence of the Human Pathogen Aspergillus fumigatus by Jöhnk, Bastian, Bayram, Özgür, Abelmann, Anja, Heinekamp, Thorsten, Mattern, Derek J, Brakhage, Axel A, Jacobsen, Ilse D, Valerius, Oliver, Braus, Gerhard H

“…F-box proteins share the F-box domain to connect substrates of E3 SCF ubiquitin RING ligases through the adaptor Skp1/A to Cul1/A scaffolds. F-box protein…”
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Functional Reconstitution of a Fungal Natural Product Gene Cluster by Advanced Genome Editing by Weber, Jakob, Valiante, Vito, Nødvig, Christina S, Mattern, Derek J, Slotkowski, Rebecca A, Mortensen, Uffe H, Brakhage, Axel A

“…Filamentous fungi produce varieties of natural products even in a strain dependent manner. However, the genetic basis of chemical speciation between strains is…”
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Rewiring of the Austinoid Biosynthetic Pathway in Filamentous Fungi by Mattern, Derek J, Valiante, Vito, Horn, Fabian, Petzke, Lutz, Brakhage, Axel A

“…Filamentous fungi produce numerous high-value natural products (NPs). The biosynthetic genes for NPs are normally clustered in the genome. A valuable NP class…”
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Discovery of an Extended Austinoid Biosynthetic Pathway in Aspergillus calidoustus by Valiante, Vito, Mattern, Derek J, Schüffler, Anja, Horn, Fabian, Walther, Grit, Scherlach, Kirstin, Petzke, Lutz, Dickhaut, Joachim, Guthke, Reinhard, Hertweck, Christian, Nett, Markus, Thines, Eckhard, Brakhage, Axel A

“…Filamentous fungi produce a wide range of natural products that are commonly used in various industrial contexts (e.g., pharmaceuticals and insecticides)…”
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Synthetic biology of fungal natural products by Mattern, Derek J, Valiante, Vito, Unkles, Shiela E, Brakhage, Axel A

“…Synthetic biology is an ever-expanding field in science, also encompassing the research area of fungal natural product (NP) discovery and production. Until…”
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Facile assembly and fluorescence-based screening method for heterologous expression of biosynthetic pathways in fungi by Hoefgen, Sandra, Lin, Jun, Fricke, Janis, Stroe, Maria C., Mattern, Derek J., Kufs, Johann E., Hortschansky, Peter, Brakhage, Axel A., Hoffmeister, Dirk, Valiante, Vito

“…Heterologous expression of multi-gene biosynthetic pathways in eukaryotic hosts is limited by highly regulated individual monocistrons. Dissimilar to…”
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Lichen-like association of Chlamydomonas reinhardtii and Aspergillus nidulans protects algal cells from bacteria by Krespach, Mario K. C., García-Altares, María, Flak, Michal, Hanno Schoeler, Scherlach, Kirstin, Netzker, Tina, Schmalzl, Anica, Mattern, Derek J., Schroeckh, Volker, Komor, Anna, Mittag, Maria, Hertweck, Christian, Brakhage, Axel A.

“…Organismal interactions within microbial consortia and their responses to harmful intruders remain largely understudied. An important step toward the goal of…”
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Aspergillus fumigatus protein phosphatase PpzA is involved in iron assimilation, secondary metabolite production, and virulence by Manfiolli, Adriana Oliveira, Castro, Patrícia Alves, Reis, Thaila Fernanda, Dolan, Stephen, Doyle, Sean, Jones, Gary, Riaño Pachón, Diego M., Ulaş, Mevlüt, Noble, Luke M., Mattern, Derek J., Brakhage, Axel A., Valiante, Vito, Silva‐Rocha, Rafael, Bayram, Ozgur, Goldman, Gustavo H.

“…Summary Metal restriction imposed by mammalian hosts during an infection is a common mechanism of defence to reduce or avoid the pathogen infection. Metals are…”
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The hypoxia‐induced dehydrogenase HorA is required for coenzyme Q10 biosynthesis, azole sensitivity and virulence of Aspergillus fumigatus by Kroll, Kristin, Shekhova, Elena, Mattern, Derek J., Thywissen, Andreas, Jacobsen, Ilse D., Strassburger, Maria, Heinekamp, Thorsten, Shelest, Ekaterina, Brakhage, Axel A., Kniemeyer, Olaf

“…Summary Aspergillus fumigatus is the predominant airborne pathogenic fungus causing invasive aspergillosis in immunocompromised patients. During infection…”
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Biosynthesis of the Sphingolipid Inhibitors Sphingofungins in Filamentous Fungi Requires Aminomalonate as a Metabolic Precursor by Bissell, Alexander U, Rautschek, Julia, Hoefgen, Sandra, Raguž, Luka, Mattern, Derek J, Saeed, Nauman, Janevska, Slavica, Jojić, Katarina, Huang, Ying, Kufs, Johann E, Herboeck, Barbara, Guo, Huijuan, Hillmann, Falk, Beemelmanns, Christine, Valiante, Vito

“…Sphingofungins belong to a group of structurally related sphingolipid inhibitors produced by fungi, which specifically inhibit serine palmitoyl transferases,…”
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Synthetic biology tools for bioprospecting of natural products in eukaryotes by Unkles, Shiela E, Valiante, Vito, Mattern, Derek J, Brakhage, Axel A

“…Filamentous fungi have the capacity to produce a battery of natural products of often unknown function, synthesized by complex metabolic pathways…”
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Draft Genome Sequence of the Fungus Penicillium brasilianum MG11 by Horn, Fabian, Linde, Jörg, Mattern, Derek J, Walther, Grit, Guthke, Reinhard, Brakhage, Axel A, Valiante, Vito

“…The genus Penicillium belongs to the phylum Ascomycota and includes a variety of fungal species important for food and drug production. We report the draft…”
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Draft Genome Sequences of Fungus Aspergillus calidoustus by Horn, Fabian, Linde, Jörg, Mattern, Derek J, Walther, Grit, Guthke, Reinhard, Scherlach, Kirstin, Martin, Karin, Brakhage, Axel A, Petzke, Lutz, Valiante, Vito

“…Here, we report the draft genome sequence of Aspergillus calidoustus (strain SF006504). The functional annotation of A. calidoustus predicts a relatively large…”
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Virulence determinants of the human pathogenic fungus A spergillus fumigatus protect against soil amoeba predation by Hillmann, Falk, Novohradská, Silvia, Mattern, Derek J., Forberger, Tilmann, Heinekamp, Thorsten, Westermann, Martin, Winckler, Thomas, Brakhage, Axel A.

“…Summary Filamentous fungi represent classical examples for environmentally acquired human pathogens whose major virulence mechanisms are likely to have emerged…”
Get full text