Isolated intracranial Rosai-Dorfman disease: report of two cases and a review of the literature

Isolated intracranial Rosai-Dorfman disease: report of two cases and a review of the literature

Rosai-Dorfman disease (RDD) is a rare but well-recognized idiopathic histioproliferative disease affecting the systemic lymph nodes. It is characterized by an unusual proliferation of histiocytic cells. Intracranial localization is a rare manifestation of RDD. The clinical and radiological different...

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Bibliographic Details
Published in:Turkish neurosurgery Vol. 23; no. 4; pp. 509 - 513
Main Authors: Abdel-Razek, Mamdouh, Matter, Ghazi Ahmed, Azab, Waleed Abdelfattah, Katchy, Kenneth Chukwuka, Mallik, Anupama Arora
Format: Journal Article
Language:English
Published: Turkey 2013
Subjects:
Adult
Antigens, CD - metabolism
Antigens, Differentiation, Myelomonocytic - metabolism
Craniotomy
Diagnosis, Differential
Dizziness - etiology
Emperipolesis
Female
Fibrosis
Headache - etiology
Histiocytes - pathology
Histiocytosis, Sinus - pathology
Histiocytosis, Sinus - surgery
Humans
Immunohistochemistry
Magnetic Resonance Imaging
Male
S100 Proteins - metabolism
Seizures - etiology
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Summary:Rosai-Dorfman disease (RDD) is a rare but well-recognized idiopathic histioproliferative disease affecting the systemic lymph nodes. It is characterized by an unusual proliferation of histiocytic cells. Intracranial localization is a rare manifestation of RDD. The clinical and radiological differentiation from meningiomas is difficult, and can only be achieved after histological examination. This entity should be considered in the differential diagnosis of dural based lesions mimicking meningioma. We report 2 cases of isolated intracranial RDD. The first patient had a large frontal lesion in addition to smaller multiple intracranial lesions. The second patient had only one parasagittal lesion. The diagnosis was confirmed on histopathological examination after surgical excision. The pertinent literature is also reviewed.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
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ISSN:1019-5149
DOI:10.5137/1019-5149.JTN.4275-11.2