Search Results - "Matter, Brock A."

Corneal Permeability and Uptake of Twenty-Five Drugs: Species Comparison and Quantitative Structure-Permeability Relationships by Santana, Cleildo P, Matter, Brock A, Patil, Madhoosudan A, Silva-Cunha, Armando, Kompella, Uday B

“…The purpose of this study was to determine corneal permeability and uptake in rabbit, porcine, and bovine corneas for twenty-five drugs using an N-in-1…”
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Hot-Melt Extrusion-Based Dexamethasone-PLGA Implants: Physicochemical, Physicomechanical, and Surface Morphological Properties and In Vitro Release Corrected for Drug Degradation by Ghaffari, Alireza Allen, Matter, Brock A, Hartman, Rachel R, Bourne, David W A, Wang, Yan, Choi, Stephanie, Kompella, Uday B

“…Developing bioequivalent (BE) generic products of complex dosage forms like intravitreal implants (IVIs) of corticosteroids such as dexamethasone prepared…”
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Brain Distribution and Metabolism of Flupirtine, a Nonopioid Analgesic Drug with Antiseizure Effects, in Neonatal Rats by Patil, Madhoosudan A, Matter, Brock A, Raol, Yogendra H, Bourne, David W A, Kelley, Ryan A, Kompella, Uday B

“…Flupirtine, a nonopioid analgesic drug, is effective in treating neonatal seizures. However, its brain delivery and pharmacokinetics are unknown in neonatal…”
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GLUTATHIONE TRAPPING TO MEASURE MICROSOMAL OXIDATION OF FURAN TO CIS-2-BUTENE-1,4-DIAL by PETERSON, Lisa A, CUMMINGS, Meredith E, VU, Choua C, MATTER, Brock A

“…Furan is a liver carcinogen and toxicant. Furan is oxidized to the reactive dialdehyde, cis -2-butene-1,4-dial, by microsomal enzymes. This reactive metabolite…”
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Electron Withdrawing Substituents on Equatorial and Apical Phosphines Have Opposite Effects on the Regioselectivity of Rhodium Catalyzed Hydroformylation by Casey, Charles P, Paulsen, Evelyn Lin, Beuttenmueller, Eckart W, Proft, Bernd R, Petrovich, Lori M, Matter, Brock A, Powell, Douglas R

“…The electronic effects of electron withdrawing aryl substituents on equatorial and apical diphosphines were investigated. Chelating diphosphines designed to…”
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The role of KCC2 in hyperexcitability of the neonatal brain by Raol, Yogendra H., Joksimovic, Srdjan M., Sampath, Dayalan, Matter, Brock A., Lam, Philip M., Kompella, Uday B., Todorovic, Slobodan M., González, Marco I.

“…•The functional role of KCC2 in preventing overexcitation in neonatal brain is not clear.•We show that reducing KCC2 activity exacerbates neonatal brain…”
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Comparative metabolism of furan in rodent and human cryopreserved hepatocytes by Gates, Leah A, Phillips, Martin B, Matter, Brock A, Peterson, Lisa A

“…Furan is a liver toxicant and carcinogen in rodents. Although humans are most likely exposed to furan through a variety of sources, the effect of furan…”
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Quantitative Analysis of Trihydroxybutyl Mercapturic Acid, a Urinary Metabolite of 1,3-Butadiene, in Humans by Kotapati, Srikanth, Matter, Brock A, Grant, Amy L, Tretyakova, Natalia Y

“…1,3-Butadiene (BD) is a known human carcinogen present in cigarette smoke and in automobile exhaust, leading to widespread exposure of human populations. BD…”
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Identification of a cis-2-Butene-1,4-dial-derived Glutathione Conjugate in the Urine of Furan-Treated Rats by Peterson, Lisa A, Cummings, Meredith E, Chan, Jacqueline Y, Vu, Choua C, Matter, Brock A

“…The hepatocarcinogen and toxicant furan requires metabolic activation to elicit its toxic effects. The available experimental evidence indicates that the…”
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Electronically Dissymmetric DIPHOS Derivatives Give Higher n:i Regioselectivity in Rhodium-Catalyzed Hydroformylation Than Either of Their Symmetric Counterparts by Casey, Charles P, Paulsen, Evelyn Lin, Beuttenmueller, Eckart W, Proft, Bernd R, Matter, Brock A, Powell, Douglas R

“…Electronic effects on rhodium-catalyzed hydroformylation of 1-hexene with electronically dissymmetric DIPHOS derivatives [3,5-(CF3)2C6H3]2PCH2CH2PPh2 =…”
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Glutathione trapping to measure microsomal oxidation off furan to cis-2-butene-1,4-dial by Peterson, Lisa A, Cummings, Meredith E, Vu, Choua C, Matter, Brock A

“…Furan is a liver carcinogen and toxicant. Furan is oxidized to the reactive dialdehyde, cis-2-butene-1,4-dial, by microsomal enzymes. This reactive metabolite…”
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