Search Results - "Matteini, Francesca"

Aging of the Hematopoietic Stem Cell Niche: New Tools to Answer an Old Question by Matteini, Francesca, Mulaw, Medhanie A, Florian, M Carolina

“…The hematopoietic stem cell (HSC) niche is a specialized microenvironment, where a complex and dynamic network of interactions across multiple cell types…”
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Cis inhibition of NOTCH1 through JAGGED1 sustains embryonic hematopoietic stem cell fate by Thambyrajah, Roshana, Maqueda, Maria, Neo, Wen Hao, Imbach, Kathleen, Guillén, Yolanda, Grases, Daniela, Fadlullah, Zaki, Gambera, Stefano, Matteini, Francesca, Wang, Xiaonan, Calero-Nieto, Fernando J., Esteller, Manel, Florian, Maria Carolina, Porta, Eduard, Benedito, Rui, Göttgens, Berthold, Lacaud, Georges, Espinosa, Lluis, Bigas, Anna

“…Hematopoietic stem cells (HSCs) develop from the hemogenic endothelium (HE) in the aorta- gonads-and mesonephros (AGM) region and reside within Intra-aortic…”
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Caveolin1 and YAP drive mechanically induced mesothelial to mesenchymal transition and fibrosis by Strippoli, Raffaele, Sandoval, Pilar, Moreno-Vicente, Roberto, Rossi, Lucia, Battistelli, Cecilia, Terri, Michela, Pascual-Antón, Lucía, Loureiro, Marta, Matteini, Francesca, Calvo, Enrique, Jiménez-Heffernan, José Antonio, Gómez, Manuel José, Jiménez-Jiménez, Victor, Sánchez-Cabo, Fátima, Vázquez, Jesús, Tripodi, Marco, López-Cabrera, Manuel, del Pozo, Miguel Ángel

“…Despite their emerging relevance to fully understand disease pathogenesis, we have as yet a poor understanding as to how biomechanical signals are integrated…”
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The long non-coding RNA Kcnq1ot1 controls maternal p57 expression in muscle cells by promoting H3K27me3 accumulation to an intragenic MyoD-binding region by Andresini, Oriella, Rossi, Marianna Nicoletta, Matteini, Francesca, Petrai, Stefano, Santini, Tiziana, Maione, Rossella

“…The cell-cycle inhibitor p57 plays a critical role in mammalian development by coordinating cell proliferation and differentiation in many cell types. p57…”
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Mesenchymal stromal cell secreted sphingosine 1-phosphate (S1P) exerts a stimulatory effect on skeletal myoblast proliferation by Sassoli, Chiara, Frati, Alessia, Tani, Alessia, Anderloni, Giulia, Pierucci, Federica, Matteini, Francesca, Chellini, Flaminia, Zecchi Orlandini, Sandra, Formigli, Lucia, Meacci, Elisabetta

“…Bone-marrow-derived mesenchymal stromal cells (MSCs) have the potential to significantly contribute to skeletal muscle healing through the secretion of…”
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Transplanting rejuvenated blood stem cells extends lifespan of aged immunocompromised mice by Montserrat-Vazquez, Sara, Ali, Noelle J., Matteini, Francesca, Lozano, Javier, Zhaowei, Tu, Mejia-Ramirez, Eva, Marka, Gina, Vollmer, Angelika, Soller, Karin, Sacma, Mehmet, Sakk, Vadim, Mularoni, Loris, Mallm, Jan Philipp, Plass, Mireya, Zheng, Yi, Geiger, Hartmut, Florian, M. Carolina

“…One goal of regenerative medicine is to rejuvenate tissues and extend lifespan by restoring the function of endogenous aged stem cells. However, evidence that…”
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Sphingosine 1-Phosphate Receptor 1 Is Required for MMP-2 Function in Bone Marrow Mesenchymal Stromal Cells: Implications for Cytoskeleton Assembly and Proliferation by Zecchi-Orlandini, Sandra, Meacci, E., Nosi, Daniele, Vestri, Ambra, Matteini, Francesca, Chellini, Flaminia, Frati, Alessia, Tani, Alessia, Pierucci, Federica, Sassoli, Chiara, Anderloni, Giulia

“…This paper is dedicated to the dear memory of Lucia Formigli who has passed away on March 18, 2014…”
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The gut-bone marrow axis: a novel player in HSC aging by Matteini, Francesca, Florian, M. Carolina

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Rejuvenating aged stem cells: therapeutic strategies to extend health and lifespan by Matteini, Francesca, Montserrat‐Vazquez, Sara, Florian, M. Carolina

“…Aging is associated with a global decline in stem cell function. To date, several strategies have been proposed to rejuvenate aged stem cells: most of these…”
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Poly(ADP-ribose) Polymerase 1 (PARP1) restrains MyoD-dependent gene expression during muscle differentiation by Matteini, Francesca, Andresini, Oriella, Petrai, Stefano, Battistelli, Cecilia, Rossi, Marianna Nicoletta, Maione, Rossella

“…The myogenic factor MyoD regulates skeletal muscle differentiation by interacting with a variety of chromatin-modifying complexes. Although MyoD can induce and…”
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3074 – DISSECTING THE INTERACTIONS BETWEEN LEUKEMIC CELLS AND THE AGING BONE MARROW NICHE by ferrer-Perez, Alba, Andersson, Rebecca, Matteini, Francesca, Zjablovskaja, Polina, Mejia-Ramirez, Eva, Lozano, Javier, Montserrat-Vazquez, Sara, Marka, Gina, Mulaw, Medhanie A., Florian, Maria Carolina

“…AML is a hematological disorder with a median age at onset of 70 years. TP53 mutations are observed in 5–10% of young adult AML cases, while TP53 mutation…”
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3188 – WNT LIGAND SECRETION REGULATES EMERGENCY GRANULOPOEISIS BY INDUCING MYELOID DIFFERENTIATION by Vanickova, Karolina, Danek, Petr, Milosevic, Mirko, Adamcova, Miroslava, Matteini, Francesca, Janeckova, Lucie, Korinek, Vladimir, Florian, M. Carolina, Rohlena, Jakub, Rohlenova, Katerina, Alberich-Jorda, Meritxell

“…β-catenin-TCF/LEF-mediated transcription in hematopoietic stem and progenitor cells (HSPCs) is critical for myeloid differentiation during bacterial…”
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Involvement of released sphingosine 1-phosphate/sphingosine 1-phosphate receptor axis in skeletal muscle atrophy by Pierucci, Federica, Frati, Alessia, Battistini, Chiara, Matteini, Francesca, Iachini, Maria Chiara, Vestri, Ambra, Penna, Fabio, Costelli, Paola, Meacci, Elisabetta

“…Skeletal muscle (SkM) atrophy is caused by several and heterogeneous conditions, such as cancer, neuromuscular disorders and aging. In most types of SkM…”
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1003 – TRANSPLANTING REJUVENATED BLOOD STEM CELLS EXTENDS LIFESPAN OF AGED MICE by Florian, M. Carolina, Montserrat-Vazquez, Sara, Ali, Noelle, Matteini, Francesca, Lozano, Javier, Mejia-Ramirez, Eva, Sakk, Vadim, Soller, Karin, Vollmer, Angelika, Sacma, Mehmet, Zhaowei, Tu, Mallm, Jan-Philipp, Plass, Mireya, Zheng, Yi, Geiger, Hartmut

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3010 – REJUVENATING BLOOD STEM CELLS EXTENDS LIFESPAN OF AGED IMMUNOCOMPROMISED MICE by Matteini, Francesca, Montserrat-Vazquez, Sara, Ali, Noelle, Lozano, Javier, Zhaowei, Tu, de Arellano, Eva Mejia-Ramirez, Marka, Gina, Vollmer, Angelika, Soller, Karin, Saçma, Mehmet, Sakk, Vadim, Mularoni, Loris, Mallm, Jan Phillip, Plass, Mireya, Zheng, Yi, Geiger, Hartmut, Florian, Maria Carolina

“…Aging is associated with loss of stem cell regenerative capacity in many tissues. Restoration of aged stem cell function represents a promising strategy to…”
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Fast and high-fidelity in situ 3D imaging protocol for stem cells and niche components for mouse organs and tissues by Saçma, Mehmet, Matteini, Francesca, Mulaw, Medhanie A., Hageb, Ali, Bogeska, Ruzhica, Sakk, Vadim, Vollmer, Angelika, Marka, Gina, Soller, Karin, Milsom, Michael D., Florian, Maria Carolina, Geiger, Hartmut

“…Quantitative 3D imaging of organ-wide cellular and subcellular components is central for revealing and understanding complex interactions between stem cells…”
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Transcriptional regulation of p57 kip2 expression during development, differentiation and disease by Rossi, Marianna N, Andresini, Oriella, Matteini, Francesca, Maione, Rossella

“…p57 is the most complex member of the CIP/KIP family of cyclin-dependent kinase inhibitors and plays a fundamental role in regulating cell cycle and…”
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3014 – ENDOTHELIAL-JAG2 PRESERVES HSC FUNCTION UPON AGING BY MAINTAINING HSC EPIGENETIC POLARITY THROUGH NOTCH SIGNALING ACTIVATION by Matteini, Francesca, Thambyrajah, Roshana, Bartolome, Javier Lozano, Perez, Alba Ferrer, Mejia-Ramirez, Eva, Vazquez, Sara Montserrat, Molinero, Patricia Herrero, Miranda, Jessica Gonzalez, Bigas, Anna, Florian, Maria Carolina

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Mesenchymal Stromal Cell Secreted Sphingosine 1-Phosphate (S1P) Exerts a Stimulatory Effect on Skeletal Myoblast Proliferation: e108662 by Sassoli, Chiara, Frati, Alessia, Tani, Alessia, Anderloni, Giulia, Pierucci, Federica, Matteini, Francesca, Chellini, Flaminia, Orlandini, Sandra Zecchi, migli, Lucia, Meacci, Elisabetta

“…Bone-marrow-derived mesenchymal stromal cells (MSCs) have the potential to significantly contribute to skeletal muscle healing through the secretion of…”
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