Search Results - "Mattavelli, Greta"
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Perivascular tenascin C triggers sequential activation of macrophages and endothelial cells to generate a pro-metastatic vascular niche in the lungs
Published in Nature cancer (01-04-2022)“…Disseminated cancer cells frequently lodge near vasculature in secondary organs. However, our understanding of the cellular crosstalk invoked at perivascular…”
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PAF1c links S-phase progression to immune evasion and MYC function in pancreatic carcinoma
Published in Nature communications (16-02-2024)“…In pancreatic ductal adenocarcinoma (PDAC), endogenous MYC is required for S-phase progression and escape from immune surveillance. Here we show that MYC in…”
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The T-Cell Metabolic Phenotype Is Dependent on Risk Status and Degree of PC Bone Marrow Infiltration in Multiple Myeloma
Published in Blood (15-11-2022)Get full text
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Spatial Transcriptomics Reveals a Multi Cellular Ecosystem in Extramedullary Multiple Myeloma
Published in Blood (15-11-2022)Get full text
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Spatial transcriptomics reveals profound subclonal heterogeneity and T-cell dysfunction in extramedullary myeloma
Published in Blood (14-11-2024)“…•EMD mimics the architectural complexity of solid tumors, marked by diverse microenvironments, multiclonality, and TNFRSF17 and GPRC5D levels.•EMD shows…”
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Fate mapping and scRNA sequencing reveal origin and diversity of lymph node stromal precursors
Published in Immunity (Cambridge, Mass.) (12-04-2022)“…Lymph node (LN) stromal cells play a crucial role in LN development and in supporting adaptive immune responses. However, their origin, differentiation…”
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Tumor-derived GDF-15 blocks LFA-1 dependent T cell recruitment and suppresses responses to anti-PD-1 treatment
Published in Nature communications (20-07-2023)“…Immune checkpoint blockade therapy is beneficial and even curative for some cancer patients. However, the majority don’t respond to immune therapy. Across…”
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