Search Results - "Mattarollo, Stephen R."

Pivotal Role of Innate and Adaptive Immunity in Anthracycline Chemotherapy of Established Tumors by MATTAROLLO, Stephen R, LOI, Sherene, DURET, Helene, MA, Yuting, ZITVOGEL, Laurence, SMYTH, Mark J

“…We show, in a series of established experimental breast adenocarcinomas and fibrosarcomas induced by carcinogen de novo in mice, that the therapeutic efficacy…”
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Anticancer Chemotherapy-Induced Intratumoral Recruitment and Differentiation of Antigen-Presenting Cells by Ma, Yuting, Adjemian, Sandy, Mattarollo, Stephen R., Yamazaki, Takahiro, Aymeric, Laetitia, Yang, Heng, Portela Catani, João Paulo, Hannani, Dalil, Duret, Helene, Steegh, Kim, Martins, Isabelle, Schlemmer, Frederic, Michaud, Mickaël, Kepp, Oliver, Sukkurwala, Abdul Qader, Menger, Laurie, Vacchelli, Erika, Droin, Nathalie, Galluzzi, Lorenzo, Krzysiek, Roman, Gordon, Siamon, Taylor, Philip R., Van Endert, Peter, Solary, Eric, Smyth, Mark J., Zitvogel, Laurence, Kroemer, Guido

“…The therapeutic efficacy of anthracyclines relies on antitumor immune responses elicited by dying cancer cells. How chemotherapy-induced cell death leads to…”
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The prognostic significance of circulating tumor cells in head and neck and non‐small‐cell lung cancer by Kulasinghe, Arutha, Kapeleris, Joanna, Kimberley, Rebecca, Mattarollo, Stephen R., Thompson, Erik W., Thiery, Jean‐Paul, Kenny, Liz, O’Byrne, Ken, Punyadeera, Chamindie

“…Tumor biopsy is the gold standard for the assessment of clinical biomarkers for treatment. However, tumors change dynamically in response to therapy, and there…”
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Invariant Natural Killer T Cells in Immune Regulation of Blood Cancers: Harnessing Their Potential in Immunotherapies by Lam, Pui Yeng, Nissen, Michael D, Mattarollo, Stephen R

“…Invariant natural killer T (iNKT) cells are a unique innate T lymphocyte population that possess cytolytic properties and profound immunoregulatory activities…”
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Regulation of immune responses to HPVinfection and during HPV-directed immunotherapy by Bhat, Purnima, Mattarollo, Stephen R., Gosmann, Christina, Frazer, Ian H., Leggatt, Graham R.

“…The recent development of vaccines prophylactic against human papillomavirus (HPV) infection has the potential to reduce the incidence of cervical cancer…”
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NKT cell adjuvant-based tumor vaccine for treatment of myc oncogene-driven mouse B-cell lymphoma by Mattarollo, Stephen R., West, Alison C., Steegh, Kim, Duret, Helene, Paget, Christophe, Martin, Ben, Matthews, Geoffrey M., Shortt, Jake, Chesi, Marta, Bergsagel, P. Leif, Bots, Michael, Zuber, Johannes, Lowe, Scott W., Johnstone, Ricky W., Smyth, Mark J.

“…Immunomodulators are effective in controlling hematologic malignancy by initiating or reactivating host antitumor immunity to otherwise poorly immunogenic and…”
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Intratumoural administration of an NKT cell agonist with CpG promotes NKT cell infiltration associated with an enhanced antitumour response and abscopal effect by Prasit, Kef K, Ferrer-Font, Laura, Burn, Olivia K, Anderson, Regan J, Compton, Benjamin J, Schmidt, Alfonso J, Mayer, Johannes U, Chen, Chun-Jen J, Dasyam, Nathaniel, Ritchie, David S, Godfrey, Dale I, Mattarollo, Stephen R, Dunbar, P Rod, Painter, Gavin F, Hermans, Ian F

“…Intratumoural administration of unmethylated cytosine-phosphate-guanine motifs (CpG) to stimulate toll-like receptor (TLR)-9 has been shown to induce tumour…”
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Langerhans cell homeostasis and activation is altered in hyperplastic human papillomavirus type 16 E7 expressing epidermis by Abd Warif, Nor Malia, Stoitzner, Patrizia, Leggatt, Graham R, Mattarollo, Stephen R, Frazer, Ian H, Hibma, Merilyn H

“…It has previously been shown that expression of human papillomavirus type 16 (HPV) E7 in epidermis causes hyperplasia and chronic inflammation, characteristics…”
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Recruitment of Antigen Presenting Cells to Skin Draining Lymph Node From HPV16E7-Expressing Skin Requires E7-Rb Interaction by Kuo, Paula, Teoh, Siok Min, Tuong, Zewen K, Leggatt, Graham R, Mattarollo, Stephen R, Frazer, Ian H

“…"High-risk" human papillomaviruses (HPV) infect keratinocytes of squamous epithelia. The HPV16E7 protein induces epithelial hyperplasia by binding Rb family…”
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Expression of a single, viral oncoprotein in skin epithelium is sufficient to recruit lymphocytes by Choyce, Allison, Yong, Michelle, Narayan, Sharmal, Mattarollo, Stephen R, Liem, Amy, Lambert, Paul F, Frazer, Ian H, Leggatt, Graham R

“…Established cancers are frequently associated with a lymphocytic infiltrate that fails to clear the tumour mass. In contrast, the importance of recruited…”
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Therapeutic vaccination with 4-1BB co-stimulation eradicates mouse acute myeloid leukemia by Kerage, Daniel, Soon, Megan S. F., Doff, Brianna L., Kobayashi, Takumi, Nissen, Michael D., Lam, Pui Yeng, Leggatt, Graham R., Mattarollo, Stephen R.

“…Immunomodulatory therapies can effectively control haematological malignancies. Previously we reported the effectiveness of combination immunotherapies that…”
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B cell lymphoma progression promotes the accumulation of circulating Ly6Clo monocytes with immunosuppressive activity by McKee, Sara J., Tuong, Zewen K., Kobayashi, Takumi, Doff, Brianna L., Soon, Megan SF, Nissen, Michael, Lam, Pui Yeng, Keane, Colm, Vari, Frank, Moi, Davide, Mazzieri, Roberta, Leggatt, Graham, Gandhi, Maher K., Mattarollo, Stephen R.

“…Monocytosis is considered a poor prognostic factor for many cancers, including B cell lymphomas. The mechanisms by which different monocyte subsets support the…”
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Natural killer cell metabolism by Kobayashi, Takumi, Mattarollo, Stephen R.

“…•Different activation stimuli cause metabolic alterations in NK cells.•mTOR pathway activation is a key regulator of NK cell function.•NK cell dysfunction in…”
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Interaction of neurotransmitters and neurochemicals with lymphocytes by Kerage, Daniel, Sloan, Erica K., Mattarollo, Stephen R., McCombe, Pamela A.

“…Neurotransmitters and neurochemicals can act on lymphocytes by binding to receptors expressed by lymphocytes. This review describes lymphocyte expression of…”
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Chemotherapy pretreatment sensitizes solid tumor‐derived cell lines to Vα24+ NKT cell‐mediated cytotoxicity by Mattarollo, Stephen R., Kenna, Tony, Nieda, Mie, Nicol, Andrew J.

“…There is an increasing awareness of the therapeutic potential for combining immune‐based therapies with chemotherapy in the treatment of malignant diseases,…”
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Increased lipid metabolism impairs NK cell function and mediates adaptation to the lymphoma environment by Kobayashi, Takumi, Lam, Pui Yeng, Jiang, Hui, Bednarska, Karolina, Gloury, Renee, Murigneux, Valentine, Tay, Joshua, Jacquelot, Nicolas, Li, Rui, Tuong, Zewen Kelvin, Leggatt, Graham R., Gandhi, Maher K., Hill, Michelle M., Belz, Gabrielle T., Ngo, Shyuan, Kallies, Axel, Mattarollo, Stephen R.

“…Natural killer (NK) cells play critical roles in protection against hematological malignancies but can acquire a dysfunctional state, which limits antitumor…”
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β-Adrenergic Signaling Impairs Antitumor CD8 + T-cell Responses to B-cell Lymphoma Immunotherapy by Nissen, Michael D, Sloan, Erica K, Mattarollo, Stephen R

“…β-Adrenergic receptor (βAR) signaling regulates many physiological processes, including immune system responses. There is growing evidence also for βAR-induced…”
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An intact immune system is required for the anticancer activities of histone deacetylase inhibitors by West, Alison C, Mattarollo, Stephen R, Shortt, Jake, Cluse, Leonie A, Christiansen, Ailsa J, Smyth, Mark J, Johnstone, Ricky W

“…Cell-intrinsic effects such as induction of apoptosis and/or inhibition of cell proliferation have been proposed as the major antitumor responses to histone…”
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IL-17 suppresses immune effector functions in human papillomavirus-associated epithelial hyperplasia by Gosmann, Christina, Mattarollo, Stephen R, Bridge, Jennifer A, Frazer, Ian H, Blumenthal, Antje

“…Persistent infection with high-risk human papillomaviruses (HPV) causes epithelial hyperplasia that can progress to cancer and is thought to depend on…”
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IL-18, but Not IL-12, Induces Production of IFN-γ in the Immunosuppressive Environment of HPV16 E7 Transgenic Hyperplastic Skin by Gosmann, Christina, Frazer, Ian H., Mattarollo, Stephen R., Blumenthal, Antje

“…IFN-γ has a central role in the defense against infections and cancer. More recently, however, IFN-γ has also been reported to have immunosuppressive effects…”
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