Search Results - "Mattaj, I."

Nucleocytoplasmic Transport by Görlich, Dirk, Mattaj, Iain W.

“…Active transport of proteins and RNAs between the nucleus and cytoplasm is a major process in eukaryotic cells. Recently, factors that recognize transport…”
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Identification of hSRP1α as a Functional Receptor for Nuclear Localization Sequences by Weis, Karsten, Mattaj, Iain W., Lamond, Angus I.

“…Import of proteins into the nucleus is a two-step process, involving nuclear localization sequence (NLS)-dependent docking of the substrate at the nuclear…”
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Generation of GTP-bound Ran by RCC1 is required for chromatin-induced mitotic spindle formation by Mattaj, Iain W, Carazo-Salas, Rafael E, Guarguaglini, Giulia, Gruss, Oliver J, Segref, Alexandra, Karsenti, Eric

“…Chromosomes are segregated by two antiparallel arrays of microtubules arranged to form the spindle apparatus. During cell division, the nucleation of cytosolic…”
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RNA recognition: a family matter? by Mattaj, I W

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Ran-GTP coordinates regulation of microtubule nucleation and dynamics during mitotic-spindle assembly by Carazo-Salas, Rafael E, Karsenti, Eric, Gruss, Oliver J, Mattaj, Iain W

“…It was recently reported that GTP-bound Ran induces microtubule and pseudo-spindle assembly in mitotic egg extracts in the absence of chromosomes and…”
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Pushing the envelope: structure, function, and dynamics of the nuclear periphery by Hetzer, Martin W, Walther, Tobias C, Mattaj, Iain W

“…The nuclear envelope (NE) is a highly specialized membrane that delineates the eukaryotic cell nucleus. It is composed of the inner and outer nuclear…”
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NUCLEOCYTOPLASMIC TRANSPORT: The Soluble Phase by Mattaj, Iain W, Englmeier, Ludwig

“…Active transport between the nucleus and cytoplasm involves primarily three classes of macromolecules: substrates, adaptors, and receptors. Some transport…”
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CRM1 Is an Export Receptor for Leucine-Rich Nuclear Export Signals by Fornerod, Maarten, Ohno, Mutsuhito, Yoshida, Minoru, Mattaj, Iain W.

“…CRM1 is distantly related to receptors that mediate nuclear protein import and was previously shown to interact with the nuclear pore complex. Overexpression…”
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Nuclear Export of Different Classes of RNA Is Mediated by Specific Factors by Jarmolowski, Artur, Boelens, Wilbert C., Izaurralde, Elisa, Mattaj, Iain W.

“…Various classes of RNA are exported from the nucleus to the cytoplasm, including transcripts of RNA polymerase I (large ribosomal RNAs), II (U-rich small…”
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Ran Induces Spindle Assembly by Reversing the Inhibitory Effect of Importin α on TPX2 Activity by Gruss, Oliver J, Carazo-Salas, Rafael E, Schatz, Christoph A, Guarguaglini, Giulia, Kast, Jürgen, Wilm, Matthias, Le Bot, Nathalie, Vernos, Isabelle, Karsenti, Eric, Mattaj, Iain W

“…The small GTPase Ran, bound to GTP, is required for the induction of spindle formation by chromosomes in M phase. High concentrations of Ran.GTP are proposed…”
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The Integral Membrane Nucleoporin pom121 Functionally Links Nuclear Pore Complex Assembly and Nuclear Envelope Formation by Antonin, Wolfram, Franz, Cerstin, Haselmann, Uta, Antony, Claude, Mattaj, Iain W.

“…The metazoan nuclear envelope (NE) breaks down and reforms at each mitosis. Nuclear pore complexes (NPCs), which allow nucleocytoplasmic transport during…”
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Nucleocytoplasmic transport: Ran, beta and beyond by Kuersten, Scott, Ohno, Mutsuhito, Mattaj, Iain W

“…Proteins, RNAs and even large macromolecular complexes are transported into and out of nuclei with remarkable rapidity and specificity. Nucleocytoplasmic…”
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Nuclear inclusion of inert and chromatin-targeted polystyrene spheres and plasmid DNA containing nanoparticles by Symens, N., Walzack, R., Demeester, J., Mattaj, I., De Smedt, S.C., Remaut, K.

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The Ran GTPase as a marker of chromosome position in spindle formation and nuclear envelope assembly by Mattaj, Iain W, Hetzer, Martin, Gruss, Oliver J

“…The small GTPase Ran is a key regulator of nucleocytoplasmic transport during interphase. The asymmetric distribution of the GTP-bound form of Ran across the…”
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Sorting out the nuclear envelope from the endoplasmic reticulum by Mattaj, Iain W

“…Although the interphase nuclear envelope is continuous with the endoplasmic reticulum, it is distinct from the endoplasmic reticulum in both form and…”
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RanGTP mediates nuclear pore complex assembly by Mattaj, Iain W, Hetzer, Martin, Walther, Tobias C, Askjaer, Peter, Gentzel, Marc, Habermann, Anja, Griffiths, Gareth, Wilm, Matthias

“…In metazoa, the nuclear envelope breaks down and reforms during each cell cycle. Nuclear pore complexes (NPCs), which serve as channels for transport between…”
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Chromosome-induced microtubule assembly mediated by TPX2 is required for spindle formation in HeLa cells by Vernos, Isabelle, Gruss, Oliver J, Wittmann, Malte, Yokoyama, Hideki, Pepperkok, Rainer, Kufer, Thomas, Silljé, Herman, Karsenti, Eric, Mattaj, Iain W

“…In Xenopus laevis egg extracts, TPX2 is required for the Ran-GTP-dependent assembly of microtubules around chromosomes. Here we show that interfering with the…”
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PHAX, a Mediator of U snRNA Nuclear Export Whose Activity Is Regulated by Phosphorylation by Ohno, Mutsuhito, Segref, Alexandra, Bachi, Angela, Wilm, Matthias, Mattaj, Iain W

“…In metazoa, assembly of spliceosomal U snRNPs requires nuclear export of U snRNA precursors. Export depends upon the RNA cap structure, nuclear cap-binding…”
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A role for nucleoporin FG repeat domains in export of human immunodeficiency virus type 1 Rev protein and RNA from the nucleus by Stutz, F., Izaurralde, E., Mattaj, I. W., Rosbash, M.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Distinct AAA-ATPase p97 complexes function in discrete steps of nuclear assembly by Mattaj, Iain W, Hetzer, Martin, Meyer, Hemmo H, Walther, Tobias C, Bilbao-Cortes, Daniel, Warren, Graham

“…Although nuclear envelope (NE) assembly is known to require the GTPase Ran, the membrane fusion machinery involved is uncharacterized. NE assembly involves…”
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