Search Results - "Matt, Peter von"

X‐ray Structures and Feasibility Assessment of CLK2 Inhibitors for Phelan–McDermid Syndrome by Kallen, Joerg, Bergsdorf, Christian, Arnaud, Bertrand, Bernhard, Mario, Brichet, Murielle, Cobos‐Correa, Amanda, Elhajouji, Azeddine, Freuler, Felix, Galimberti, Ivan, Guibourdenche, Christel, Haenni, Simon, Holzinger, Sandra, Hunziker, Juerg, Izaac, Aude, Kaufmann, Markus, Leder, Lukas, Martus, Hans‐Joerg, von Matt, Peter, Polyakov, Valery, Roethlisberger, Patrik, Roma, Guglielmo, Stiefl, Nikolaus, Uteng, Marianne, Lerchner, Andreas

“…CLK2 inhibition has been proposed as a potential mechanism to improve autism and neuronal functions in Phelan–McDermid syndrome (PMDS). Herein, the discovery…”
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Argyrins, immunosuppressive cyclic peptides from myxobacteria. I. Production, isolation, physico-chemical and biological properties by Sasse, Florenz, Steinmetz, Heinrich, Schupp, Thomas, Petersen, Frank, Memmert, Klaus, Hofmann, Hans, Heusser, Christoph, Brinkmann, Volker, von Matt, Peter, Höfle, Gerhard, Reichenbach, Hans

“…A group of cyclic peptides consisting of 8 amino acid residues, named argyrins A to H, were isolated from the culture broth of strains of the myxobacterium…”
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Discovery of 3-(1H-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione (AEB071), a Potent and Selective Inhibitor of Protein Kinase C Isotypes by Wagner, Jürgen, von Matt, Peter, Sedrani, Richard, Albert, Rainer, Cooke, Nigel, Ehrhardt, Claus, Geiser, Martin, Rummel, Gabriele, Stark, Wilhelm, Strauss, Andre, Cowan-Jacob, Sandra W, Beerli, Christian, Weckbecker, Gisbert, Evenou, Jean-Pierre, Zenke, Gerhard, Cottens, Sylvain

“…A series of novel maleimide-based inhibitors of protein kinase C (PKC) were designed, synthesized, and evaluated. AEB071 (1) was found to be a potent,…”
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Argyrins, immunosuppressive cyclic peptides from myxobacteria. II. Structure elucidation and stereochemistry by Vollbrecht, Larissa, Steinmetz, Heinrich, Hofle, Gerhard, Oberer, Lukas, Rihs, Grety, Bovermann, Günter, von Matt, Peter

“…The structures of argyrins A-H were elucidated by NMR spectroscopy, chemical degradation and X-ray analysis as cyclic octapeptides. Argyrins A and B, in…”
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Chiral Bis(oxazoline)copper(II) Complexes as Lewis Acid Catalysts for the Enantioselective Diels−Alder Reaction by Evans, David A, Miller, Scott J, Lectka, Thomas, von Matt, Peter

“…Bis(oxazoline)copper(II) complexes are highly enantioselective catalysts in Diels−Alder reactions involving bidentate dienophiles. Cationic…”
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Bis(oxazoline) and Bis(oxazolinyl)pyridine Copper Complexes as Enantioselective Diels−Alder Catalysts:  Reaction Scope and Synthetic Applications by Evans, David A, Barnes, David M, Johnson, Jeffrey S, Lectka, Thomas, von Matt, Peter, Miller, Scott J, Murry, Jerry A, Norcross, Roger D, Shaughnessy, Eileen A, Campos, Kevin R

“…The scope of the Diels−Alder reaction catalyzed by bis(oxazoline) copper complexes has been investigated. In particular, [Cu((S,S)-t-Bu-box)](SbF6)2 (1b) has…”
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2′-deoxyribo-PNAs: A structurally novel class of polyamide nucleic acids with good RNA and DNA binding affinity by Matt, Peter von, Mesmaeker, Alain De, Pieles, Uwe, Zürcher, Werner, Altmann, Karl-Heinz

“…2′-Deoxyribo polyamide nucleic acids (2′-deoxyribo-PNAs) 3 are a new class of DNA analogs with a 2′,3′-dideoxyribose-polyamide backbone structure…”
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Design and Synthesis of Potent and Selective Inhibitors of Integrin VLA-4 by Wattanasin, Sompong, Weidmann, Beat, Roche, Didier, Myers, Stewart, Xing, Amy, Guo, Qin, Sabio, Michael, von Matt, Peter, Hugo, Ronald, Maida, Susan, Lake, Philip, Weetall, Marla

“…The synthesis and identification of a novel series of inhibitors of integrin VLA-4 are described. Their in vitro activity and selectivity against closely…”
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Synthesis of novel cyclobutylphosphonic acids as inhibitors of imidazole glycerol phosphate dehydratase by Norcross, Roger D., von Matt, Peter, Kolb, Hartmuth C., Belluš, Daniel

“…Diethyl 3-oxocyclobutylphosphonate ( 5) has been synthesised via a novel one-pot cyclisation reaction of the α-phenylsulphonyl-γ,δ-epoxyphosphonate 8. Addition…”
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Indolyl-naphthyl-maleimides as potent and selective inhibitors of protein kinase C-α/β by van Eis, Maurice J., Evenou, JeanPierre, Schuler, Walter, Zenke, Gerhard, Vangrevelinghe, Eric, Wagner, Juergen, von Matt, Peter

“…[Display omitted] The indolyl-naphthyl maleimide 7 is a potent inhibitor of the classical PKC isotypes α,β and shows excellent selectivity over the novel PKC…”
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Structure–Activity Relationship and Pharmacokinetic Studies of Sotrastaurin (AEB071), a Promising Novel Medicine for Prevention of Graft Rejection and Treatment of Psoriasis by Wagner, Jürgen, von Matt, Peter, Faller, Bernard, Cooke, Nigel G, Albert, Rainer, Sedrani, Richard, Wiegand, Hansjörg, Jean, Christian, Beerli, Christian, Weckbecker, Gisbert, Evenou, Jean-Pierre, Zenke, Gerhard, Cottens, Sylvain

“…Protein kinase C (PKC) isotypes have emerged as key targets for the blockade of early T-cell activation. Herein, we report on the structure–activity…”
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RNA-Binding Affinities and Crystal Structure of Oligonucleotides Containing Five-Atom Amide-Based Backbone Structures by Pallan, Pradeep S, von Matt, Peter, Wilds, Christopher J, Altmann, Karl-Heinz, Egli, Martin

“…Among the hundreds of nucleic acid analogues that have been studied over the last two decades only very few exhibit backbones with linkers between residues…”
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Das Vertrauen in die Augen by Peter von Matt

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Pd-Catalyzed Allylic Substitution with Enantiomerically Pure Catalysts and Chiral Non-Racemic Substrates: A New Approach to Catalyst-Based Regiocontrol, Preliminary Communication by Loiseleur, Olivier, Elliott, Mark C., von Matt, Peter, Pfaltz, Andreas

“…Chiral, enantiomerically pure Pd‐catalysts were used to control the regioselectivity of nucleophilic attack in allylic substitutions with optically active…”
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An expeditious synthesis of 3′-α-carboxymethyl-2′-O-methyl ribonucleosides by von Matt, Peter, Lochmann, Thomas, Kesselring, Rudolf, Altmann, Karl-Heinz

“…3′-α-Carboxymethyl-2′-O-methyl ribonucleosides, which are important building blocks for the construction of high affinity amide modified antisense…”
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Replacement of the phosphodiester linkage in oligonucleotides by heterocycles: the effect of triazole- and imidazole-modified backbones on DNA/RNA duplex stability by von Matt, Peter, Altmann, Karl-Heinz

“…Thymidine dinucleotide analogs with imidazole-derived backbones ( III and IV) were synthesized. These modified dimeric building blocks were incorporated into…”
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STUDIES OF A CHEMICALLY MODIFIED OLIGODEOXYNUCLEOTIDE CONTAINING A 5-ATOM AMIDE BACKBONE WHICH EXHIBITS IMPROVED BINDING TO RNA by Wilds, Christopher J., Minasov, George, Natt, François, von Matt, Peter, Altmann, Karl-Heinz, Egli, Martin

“…Chimeric oligodeoxyribonucleotides where the phosphodiester linkage -C3′-O-PO 2 − -O-CH 2 -C4′- of DNA is substituted by the amide linkage -C3′-CH 2 -CH * (CH…”
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Replacement of the phosphodiester linkage in oligonucleotides by heterocycles: synthesis of thymidine dinucleotide analogs with triazole-modified backbones by von Matt, Peter, Lochmann, Thomas, Altmann, Karl-Heinz

“…Novel backbone-modified dinucleotide analogs of types V and VI have been synthesized, where the natural phosphodiester linkage of a T-T dinucleotide has been…”
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Die Augen der Automaten. E.T.A. Hoffmanns Imaginationslehre als Prinzip seiner Erzählkunst by Immerwahr, Raymond

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Der Grundriss von Grillparzers Bühnenkunst by Gittleman, Sol

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