Search Results - "Matsuzaki, Takeshi"

Novel Pan-Pim Kinase Inhibitors With Imidazopyridazine and Thiazolidinedione Structure Exert Potent Antitumor Activities by Sawaguchi, Yuichi, Yamazaki, Ryuta, Nishiyama, Yukiko, Mae, Masayuki, Abe, Atsuhiro, Nishiyama, Hiroyuki, Nishisaka, Fukiko, Ibuki, Tatsuya, Sasai, Toshio, Matsuzaki, Takeshi

“…Pim kinases are overexpressed in various types of hematological malignancies and solid carcinomas, and promote cell proliferation and survival. Here in this…”
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Bacterial Production of the Tunicate-Derived Antitumor Cyclic Depsipeptide Didemnin B by Tsukimoto, Moriya, Nagaoka, Masato, Shishido, Yoshiyuki, Fujimoto, Junji, Nishisaka, Fukiko, Matsumoto, Sachiko, Harunari, Enjuro, Imada, Chiaki, Matsuzaki, Takeshi

“…Natural products obtained from marine invertebrates such as sponges and tunicates are attractive sources of drugs. However, a critical obstacle in the…”
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YPC‐21661 and YPC‐22026, novel small molecules, inhibit ZNF143 activity in vitro and in vivo by Haibara, Hirotaka, Yamazaki, Ryuta, Nishiyama, Yukiko, Ono, Masahiro, Kobayashi, Tsuneyuki, Hokkyo‐Itagaki, Atsuko, Nishisaka, Fukiko, Nishiyama, Hiroyuki, Kurita, Akinobu, Matsuzaki, Takeshi, Izumi, Hiroto, Kohno, Kimitoshi

“…Zinc‐finger protein 143 (ZNF143) is a transcription factor that is involved in anticancer drug resistance and cancer cell survival. In the present study, we…”
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Semisynthesis of Antitrypanosomal p-Quinone Analog Possesing the Komaroviquinone Pharmacophore by Aoyagi, Yutaka, Fujiwara, Koji, Takahashi, Yoshinao, Yano, Reiko, Hitotsuyanagi, Yukio, Takeya, Koichi, Aiyama, Ritsuo, Matsuzaki, Takeshi, Hashimoto, Shusuke, Nishihara-Tsukashima, Aki, Namatame, Miyuki, Ishiyama, Aki, Iwatsuki, Masato, Otoguro, Kazuhiko, Yamada, Haruki, Ōmura, Satoshi

“…A p-quinone analog having the komaroviquinone pharmacophore fused with a more conformationally flexible cycloheptane ring, was semisynthesized from natural…”
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Comparative studies of irinotecan-loaded polyethylene glycol-modified liposomes prepared using different PEG-modification methods by Yoshino, Keisuke, Nakamura, Koji, Terajima, Yoko, Kurita, Akinobu, Matsuzaki, Takeshi, Yamashita, Keiko, Isozaki, Masashi, Kasukawa, Hiroaki

“…Recently, a polyethylene glycol (PEG)-modification method for liposomes prepared using pH-gradient method has been proposed. The differences in the…”
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Three-dimensional Cellular Spheroid Formation Provides Human Prostate Tumor Cells with Tissue-like Features by TAKAGI, Akimitsu, WATANABE, Masatoshi, ISHII, Yasuhisa, MORITA, Joji, HIROKAWA, Yoshifumi, MATSUZAKI, Takeshi, SHIRAISHI, Taizo

“…Background: Alterations in the cellular biological responses were examined in a series of LNCaP human prostate tumor cells growing under different conditions…”
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Relationship between the in vitro response of dendritic cells to Lactobacillus and prevention of tumorigenesis in the mouse by Takagi, Akimitsu, Ikemura, Haruo, Matsuzaki, Takeshi, Sato, Mikiko, Nomoto, Koji, Morotomi, Masami, Yokokura, Teruo

“…Background Some strains of lactobacilli stimulate immune cells, yet little is known about their potency in cancer prevention. We have previously reported that…”
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Lipoteichoic acids from Lactobacillus strains elicit strong tumor necrosis factor alpha-inducing activities in macrophages through Toll-like receptor 2 by Matsuguchi, Tetsuya, Takagi, Akimitsu, Matsuzaki, Takeshi, Nagaoka, Masato, Ishikawa, Kimika, Yokokura, Teruo, Yoshikai, Yasunobu

“…Lactobacilli are nonpathogenic gram-positive inhabitants of microflora. At least some Lactobacillus strains have been postulated to have health beneficial…”
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PEGylated liposome IHL-305 markedly improved the survival of ovarian cancer peritoneal metastasis in mouse by Konishi, Hiroaki, Takagi, Akimitsu, Kurita, Akinobu, Kaneda, Norimasa, Matsuzaki, Takeshi

“…Advanced ovarian cancer is characterized by peritoneal metastasis and the accumulation of ascites. Peritoneal metastasis of ovarian cancer is a major cause of…”
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Abstract 5534: A novel and oral histone deacetylase inhibitor, resminostat, effectively suppresses the growth of non-small cell lung cancer in a xenograft mouse model by Takagi, Akimitsu, Konishi, Hiroaki, Tsugane, Momomi, Taniguchi, Keisuke, Takahashi, Hiroyuki, Inutake, Yu, Watanabe, Akinobu, Kodaira, Hiroshi, Matsuzaki, Takeshi

“…Abstract Background: Accumulating evidence reveals effectiveness of histone deacetylase (HDAC) inhibition in various types of cancer, and resminostat is a…”
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Selective cyclooxygenase-2 inhibitors show a differential ability to inhibit proliferation and induce apoptosis of colon adenocarcinoma cells by Yamazaki, Ryuta, Kusunoki, Natsuko, Matsuzaki, Takeshi, Hashimoto, Shusuke, Kawai, Shinichi

“…Although the influence of selective cyclooxygenase (COX)-2 inhibitors on the proliferation of colon adenocarcinoma cells have been the subject of much…”
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Effect of gap size created by thinning on seedling emergency, survival and establishment in a coastal pine forest by Zhu, Jiao-jun, Matsuzaki, Takeshi, Lee, Feng-qin, Gonda, Yutaka

“…It is desirable and necessary to preserve the continuity of a coastal forest through reasonable management because it can provide many shelter benefits through…”
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Rhazinilam and Quebrachamine Derivatives from Yunnan Kopsia arborea by Wu, Yuqiu, Suehiro, Mayu, Kitajima, Mariko, Matsuzaki, Takeshi, Hashimoto, Shusuke, Nagaoka, Masato, Zhang, Rongping, Takayama, Hiromitsu

“…Three new rhazinilam-derived alkaloids, kopsiyunnanines C1, C2, and C3, and a new quebrachamine-type alkaloid, kopsiyunnanine D, which possess an unusual…”
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G1P3, an interferon inducible gene 6-16, is expressed in gastric cancers and inhibits mitochondrial-mediated apoptosis in gastric cancer cell line TMK-1 cell by TAHARA, Eiji JR, TAHARA, Hidetoshi, IDE, Toshinori, TAHARA, Eiichi, KANNO, Masamoto, NAKA, Kazuhito, TAKEDA, Yayoi, MATSUZAKI, Takeshi, YAMAZAKI, Ryuta, ISHIHARA, Hiroto, YASUI, Wataru, BARRETT, J. Carl

“…Expression of an interferon inducible gene 6-16, G1P3, increases not only in type I interferon-treated cells but also in human senescent fibroblasts. However,…”
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Enhancement of natural killer cytotoxicity delayed murine carcinogenesis by a probiotic microorganism by Takagi, Akimitsu, Matsuzaki, Takeshi, Sato, Mikiko, Nomoto, Koji, Morotomi, Masami, Yokokura, Teruo

“…Regulation of innate immunity may be an effective means of cancer control. Delaying cancer onset is regarded as an important mode of action in cancer…”
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Efficacy of Combination Treatment and Influence of Schedule with Irinotecan and Amrubicin in Human Lung Carcinoma Cells in Vivo and in Vitro by Shishido, Yoshiyuki, Furuta, Tomio, Matsuzaki, Takeshi, Nagata, Hiroshi, Hashimoto, Shusuke

“…The aim of this study was to elucidate the efficacy of combination therapy with irinotecan and amrubicin for lung cancer and the influence of administration…”
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Biomimetic synthesis of grandione from demethylsalvicanol via hetero-Diels–Alder type dimerization and structure revision of grandione by Aoyagi, Yutaka, Takahashi, Yoshinao, Satake, Yudai, Fukaya, Haruhiko, Takeya, Koichi, Aiyama, Ritsuo, Matsuzaki, Takeshi, Hashimoto, Shusuke, Shiina, Tsutomu, Kurihara, Teruo

“…Grandione, a unique isetexane diterpene dimer, was synthesized from demethylsalvicanol via the solid state hetero-Diels–Alder type dimerization reaction. By…”
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Semisynthesis of Isetexane Diterpenoid Analogues and Their Cytotoxic Activity by Aoyagi, Yutaka, Takahashi, Yoshinao, Fukaya, Haruhiko, Takeya, Koichi, Aiyama, Ritsuo, Matsuzaki, Takeshi, Hashimoto, Shusuke, Kurihara, Teruo

“…Isetexane diterpene analogues were semisynthesized from demethylsalvicanol isolated from Perovskia abrotanoides (Labiatae). The structure and cytotoxic…”
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Factors affecting the snow and wind induced damage of a montane secondary forest in northeastern China by Zhu, Jiao-jun, Li, Xiu-fen, Liu, Zu-gen, Cao, Wei, Gonda, Yutaka, Matsuzaki, Takeshi

“…In order to understand the processes of snow and wind induced damage in a natural montane, secondary forest in northeastern China, we examined the impacts of…”
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Aberrant methylation of the vascular endothelial growth factor receptor‐1 gene in prostate cancer by Yamada, Yasushi, Watanabe, Masatoshi, Yamanaka, Mikio, Hirokawa, Yoshifumi, Suzuki, Hiroyoshi, Takagi, Akimitsu, Matsuzaki, Takeshi, Sugimura, Yoshiki, Yatani, Ryuichi, Shiraishi, Taizo

“…Transcriptional silencing of cancer‐related genes by DNA methylation is observed in various cancers. To identify genes controlled by methylation in prostate…”
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