Three-dimensional changes of noses after transplantation of implant-type tissue-engineered cartilage for secondary correction of cleft lip–nose patients

We have developed an implant-type tissue-engineered cartilage using a poly-l-lactide scaffold. In a clinical study, it was inserted into subcutaneous areas of nasal dorsum in three patients, to correct cleft lip–nose deformity. The aim of this study was to helping evaluation on the efficacy of the r...

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Bibliographic Details
Published in:	Regenerative therapy Vol. 7; no. C; pp. 72 - 79
Main Authors:	Hoshi, Kazuto, Fujihara, Yuko, Saijo, Hideto, Kurabayashi, Kumiko, Suenaga, Hideyuki, Asawa, Yukiyo, Nishizawa, Satoru, Kanazawa, Sanshiro, Uto, Sakura, Inaki, Ryoko, Matsuyama, Mariko, Sakamoto, Tomoaki, Watanabe, Makoto, Sugiyama, Madoka, Yonenaga, Kazumichi, Hikita, Atsuhiko, Takato, Tsuyoshi
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01-12-2017 Japanese Society for Regenerative Medicine Elsevier
Subjects:	Cartilage Cleft lip and palate Nose Original Three dimension Tissue engineering Three dimension Cartilage Tissue engineering Nose Cleft lip and palate
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Summary:	We have developed an implant-type tissue-engineered cartilage using a poly-l-lactide scaffold. In a clinical study, it was inserted into subcutaneous areas of nasal dorsum in three patients, to correct cleft lip–nose deformity. The aim of this study was to helping evaluation on the efficacy of the regenerative cartilage. 3D data of nasal shapes were compared between before and after surgery in computed tomography (CT) images. Morphological and qualitative changes of transplants in the body were also evaluated on MRI, for one year. The 3D data from CT images showed effective augmentation (>2 mm) of nasal dorsum in almost whole length, observed on the medial line of faces. It was maintained by 1 year post-surgery in all patients, while affected curves of nasal dorsum was not detected throughout the observation period. In magnetic resonance imaging (MRI), the images of transplanted cartilage had been observed until 1 year post-surgery. Those images were seemingly not straight when viewed from the longitudinal plain, and may have shown gentle adaptation to the surrounding nasal bones and alar cartilage tissues. Those findings suggested the potential efficacy of this cartilage on improvement of cleft lip–nose deformity. A clinical trial is now being performed for industrialization. •Cleft lip–nose deformity was corrected by tissue-engineered cartilage.•Effective augmentation was observed on the medial line of nasal dorsum for 1 year.•Images of transplanted cartilage had been detected by MRI until 1 year.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2352-3204 2352-3204
DOI:	10.1016/j.reth.2017.09.001