Search Results - "Matsuura, Suzanne"

HIV-1 infection is blocked at an early stage in cells devoid of mitochondrial DNA by Lu, Gaofei, Matsuura, Suzanne E, Barrientos, Antoni, Scott, Walter A

“…Human immunodeficiency virus type I (HIV-1) exploits various host cellular pathways for efficient infection. Here we report that the absence of mitochondrial…”
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Unblocking of Chain-Terminated Primer by HIV-1 Reverse Transcriptase through a Nucleotide-Dependent Mechanism by Meyer, Peter R., Matsuura, Suzanne E., So, Antero G., Scott, Walter A.

“…HIV-1 replication is inhibited by the incorporation of chain-terminating nucleotides at the 3′end of the growing DNA chain. Here we show a nucleotide-dependent…”
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A Role of Template Cleavage in Reduced Excision of Chain-Terminating Nucleotides by Human Immunodeficiency Virus Type 1 Reverse Transcriptase Containing the M184V Mutation by Acosta-Hoyos, Antonio J., Matsuura, Suzanne E., Meyer, Peter R., Scott, Walter A.

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A Mechanism of AZT Resistance: An Increase in Nucleotide-Dependent Primer Unblocking by Mutant HIV-1 Reverse Transcriptase by Meyer, Peter R, Matsuura, Suzanne E, Mian, A.Mohsin, So, Antero G, Scott, Walter A

“…Mutations in HIV-1 reverse transcriptase (RT) give rise to 3′-azido-3′-deoxythymidine (AZT) resistance by a mechanism that has not been previously reproduced…”
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Differential Removal of Thymidine Nucleotide Analogues from Blocked DNA Chains by Human Immunodeficiency Virus Reverse Transcriptase in the Presence of Physiological Concentrations of 2′-Deoxynucleoside Triphosphates by MEYER, Peter R, MATSUURA, Suzanne E, SCHINAZI, Raymond F, SO, Antero G, SCOTT, Walter A

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Effects of Dipeptide Insertions between Codons 69 and 70 of Human Immunodeficiency Virus Type 1 Reverse Transcriptase on Primer Unblocking, Deoxynucleoside Triphosphate Inhibition, and DNA Chain Elongation by Meyer, Peter R, Lennerstrand, Johan, Matsuura, Suzanne E, Larder, Brendan A, Scott, Walter A

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Chain-Terminating Dinucleoside Tetraphosphates Are Substrates for DNA Polymerization by Human Immunodeficiency Virus Type 1 Reverse Transcriptase with Increased Activity against Thymidine Analogue-Resistant Mutants by MEYER, Peter R, SMITH, Anthony J, MATSUURA, Suzanne E, SCOTT, Walter A

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Effects of Primer-Template Sequence on ATP-dependent Removal of Chain-terminating Nucleotide Analogues by HIV-1 Reverse Transcriptase by Meyer, Peter R, Smith, Anthony J, Matsuura, Suzanne E, Scott, Walter A

“…HIV-1 reverse transcriptase can remove chain terminators from blocked DNA ends through a nucleotide-dependent mechanism. We show that the catalytic efficiency…”
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Relationship between 3′-Azido-3′-Deoxythymidine Resistance and Primer Unblocking Activity in Foscarnet-Resistant Mutants of Human Immunodeficiency Virus Type 1 Reverse Transcriptase by Meyer, Peter R, Matsuura, Suzanne E, Zonarich, Dianna, Chopra, Rahul R, Pendarvis, Eric, Bazmi, Holly Z, Mellors, John W, Scott, Walter A

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Effects of Specific Zidovudine Resistance Mutations and Substrate Structure on Nucleotide-Dependent Primer Unblocking by Human Immunodeficiency Virus Type 1 Reverse Transcriptase by MEYER, Peter R, MATSUURA, Suzanne E, TOLUN, Adviye A, PFEIFER, Ingrid, SO, Antero G, MELLORS, John W, SCOTT, Walter A

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Stable Complexes Formed by HIV-1 Reverse Transcriptase at Distinct Positions on the Primer-template Controlled by Binding Deoxynucleoside Triphosphates or Foscarnet by Meyer, Peter R., Rutvisuttinunt, Wiriya, Matsuura, Suzanne E., So, Antero G., Scott, Walter A.

“…Binding of the next complementary dNTP by the binary complex containing HIV-1 reverse transcriptase (RT) and primer-template induces conformational changes…”
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Abstract A43: Therapeutic efficacy of retroviral replicating vectors in orthotopic models of breast cancer metastasis to the brain by Inagaki, Akihito, Collins, Sara, Matsuura, Suzanne, Kasahara, Noriyuki

“…Our studies to date have demonstrated that retroviral replicating vectors (RRV) are capable of highly efficient replication in cancer cells in vitro and in…”
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EXTH-65. INSERTION OF MICRORNA TARGET SEQUENCES INTO RETROVIRAL REPLICATING VECTORS EFFECTIVELY RESTRICTS TRANSGENE EXPRESSION AND VIRAL REPLICATION IN HUMAN HEMATOPOIETIC STEM AND PROGENITOR CELLS by Collins, Sara, Inagaki, Akihito, Barcova, Maria, Freedman, Alicia, Montoya, Megan, Haddad, Alexander, Hacke, Katrin, Matsuura, Suzanne, Timberlake, Nina, Lin, Amy, Jolly, Douglas, Kasahara, Noriyuki

“…Prodrug activator gene therapy with a retroviral replicating vector (RRV) has shown a highly favorable safety profile and long-term survival in early-phase…”
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Abstract A42: Alternate pseudotypes overcome receptor interference and enable combination suicide gene therapy with retroviral replicating vectors by Grosso, James, Collins, Sara, Inagaki, Akihito, Matsuura, Suzanne, Slomovitz, Brian, Ince, Tan, Kasahara, Noriyuki

“…Retroviral replicating vectors (RRVs) have been shown to achieve efficient tumor transduction and enhanced therapeutic benefit in a wide variety of cancer…”
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Prodrug Activator Gene Therapy of Ovarian Cancer using a Retroviral Replicating Vector by Collins, Sara A., Kamath, Priyanka, Grosso, James, Matsuura, Suzanne, Xu, Xiangxi, Ince, Tan, Jolly, Douglas J., Slomovitz, Brian, Kasahara, Noriyuki

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HIV-1 Infection Is Blocked at an Early Stage in Cells Devoid of Mitochondrial DNA: e78035 by Lu, Gaofei, Matsuura, Suzanne E, Barrientos, Antoni, Scott, Walter A

“…Human immunodeficiency virus type I (HIV-1) exploits various host cellular pathways for efficient infection. Here we report that the absence of mitochondrial…”
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Nucleotide-Induced Stable Complex Formation by HIV-1 Reverse Transcriptase by Tong, Wenjing, Lu, Chang-De, Sharma, Satish K, Matsuura, Suzanne, So, Antero G, Scott, Walter A

“…Nondenaturing gel electrophoresis was used to study the nucleotide substrate-induced conformational change in reverse transcriptase (RT) of human…”
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A Mechanism of AZT Resistance by Meyer, Peter R, Matsuura, Suzanne E, Mian, A.Mohsin, So, Antero G, Scott, Walter A

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Reverse transcriptase mutations in HIV-1 : Infected children treated with zidovudine by ÜNAL, A, LORENZO, E, BROWN, M, SMITH, L, MATSUURA, S, SCOTT, G, SCOTT, W

“…Human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) mutations were detected in DNA from peripheral blood mononuclear cells from 11 of 12…”
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