Search Results - "Matsushita, Shuzo"

Prediction of Contact Residues in Anti-HIV Neutralizing Antibody by Deep Learning by Kaku, Yu, Kuwata, Takeo, Gorny, Miroslaw K., Matsushita, Shuzo

“…The monoclonal antibody 1C10 targets the V3 loop of HIV-1 and neutralizes a broad range of clade B viruses. However, the mode of interaction between 1C10 and…”
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Neutralization against Omicron sublineages (BA.2/BA.5/BQ.1.1/XBB/XBB.1.5) in bivalent BNT162b2-vaccinated HCWs with or without risk factors, or following BT infection with Omicron by Amano, Masayuki, Otsu, Sachiko, Uemura, Yukari, Ichikawa, Yasuko, Matsumoto, Shota, Higashi-Kuwata, Nobuyo, Matsushita, Shuzo, Shimada, Shinya, Mitsuya, Hiroaki

“…SARS-CoV-2-BA.4/5-adapted-bivalent-BNT162b2-vaccine ( bv BNT), developed in response to the recent emergence of immune-evasive Omicron-variants, has been given…”
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Sensitivity to a CD4 mimic of a consensus clone of monkey-adapted CCR5-tropic SHIV-MK38C by Matsuura, Kanako, Yamaura, Mizuki, Sakawaki, Hiromi, Himeno, Ai, Pisil, Yalcin, Kobayakawa, Takuya, Tsuji, Kohei, Tamamura, Hirokazu, Matsushita, Shuzo, Miura, Tomoyuki

“…By acclimatizing CCR5-tropic tier 1B SHIV-MK1 to rhesus monkeys, a tier 2 SHIV-MK38 strain with neutralization resistance and high replication ability was…”
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Differential Ability of Spike Protein of SARS-CoV-2 Variants to Downregulate ACE2 by Maeda, Yosuke, Toyoda, Mako, Kuwata, Takeo, Terasawa, Hiromi, Tokugawa, Umiru, Monde, Kazuaki, Sawa, Tomohiro, Ueno, Takamasa, Matsushita, Shuzo

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 19 (COVID-19) and employs angiotensin-converting…”
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Hybrids of small CD4 mimics and gp41-related peptides as dual-target HIV entry inhibitors by Wang, Rongyi, Tsuji, Kohei, Kobayakawa, Takuya, Liu, Yishan, Yoshimura, Kazuhisa, Matsushita, Shuzo, Harada, Shigeyoshi, Tamamura, Hirokazu

“…[Display omitted] Hybrid molecules containing small CD4 mimics and gp41-C-terminal heptad repeat (CHR)-related peptides have been developed. A YIR-821…”
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Osteoporosis-Related Fractures in HIV-Infected Patients Receiving Long-Term Tenofovir Disoproxil Fumarate: An Observational Cohort Study by Komatsu, Ayami, Ikeda, Atsushi, Kikuchi, Akio, Minami, Chiaki, Tan, Motomu, Matsushita, Shuzo

“…Introduction Patients with HIV infection may have a higher prevalence of osteoporosis and osteopenia, as well as an increased risk of bone fracture compared…”
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Exploratory studies on soluble small molecule CD4 mimics as HIV entry inhibitors by Tsuji, Kohei, Kobayakawa, Takuya, Konno, Kiju, Masuda, Ami, Takahashi, Kohei, Ohashi, Nami, Yoshimura, Kazuhisa, Kuwata, Takeo, Matsushita, Shuzo, Harada, Shigeyoshi, Tamamura, Hirokazu

“…[Display omitted] Several small molecule CD4 mimics, which inhibit the interaction of gp120 with CD4, have been developed. Original CD4 mimics such as NBD-556,…”
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Structural dynamics of HIV-1 envelope Gp120 outer domain with V3 loop by Yokoyama, Masaru, Naganawa, Satoshi, Yoshimura, Kazuhisa, Matsushita, Shuzo, Sato, Hironori

“…The net charge of the hypervariable V3 loop on the HIV-1 envelope gp120 outer domain plays a key role in modulating viral phenotype. However, the molecular…”
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Incompatible Natures of the HIV-1 Envelope in Resistance to the CCR5 Antagonist Cenicriviroc and to Neutralizing Antibodies by Kuwata, Takeo, Enomoto, Ikumi, Baba, Masanori, Matsushita, Shuzo

“…Cenicriviroc is a CCR5 antagonist which prevents human immunodeficiency virus type 1 (HIV-1) from cellular entry. The CCR5-binding regions of the HIV-1…”
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Characterization of a Novel CD4 Mimetic Compound YIR-821 against HIV-1 Clinical Isolates by Matsumoto, Kaho, Kuwata, Takeo, Tolbert, William D, Richard, Jonathan, Ding, Shilei, Prévost, Jérémie, Takahama, Shokichi, Judicate, George P, Ueno, Takamasa, Nakata, Hirotomo, Kobayakawa, Takuya, Tsuji, Kohei, Tamamura, Hirokazu, Smith, 3rd, Amos B, Pazgier, Marzena, Finzi, Andrés, Matsushita, Shuzo

“…Small CD4-mimetic compound (CD4mc), which inhibits the interaction between gp120 with CD4, acts as an entry inhibitor and induces structural changes in the…”
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Resistance of SARS-CoV-2 variants to neutralization by antibodies induced in convalescent patients with COVID-19 by Kaku, Yu, Kuwata, Takeo, Zahid, Hasan Md, Hashiguchi, Takao, Noda, Takeshi, Kuramoto, Noriko, Biswas, Shashwata, Matsumoto, Kaho, Shimizu, Mikiko, Kawanami, Yoko, Shimura, Kazuya, Onishi, Chiho, Muramoto, Yukiko, Suzuki, Tateki, Sasaki, Jiei, Nagasaki, Yoji, Minami, Rumi, Motozono, Chihiro, Toyoda, Mako, Takahashi, Hiroshi, Kishi, Hiroto, Fujii, Kazuhiko, Tatsuke, Tsuneyuki, Ikeda, Terumasa, Maeda, Yosuke, Ueno, Takamasa, Koyanagi, Yoshio, Iwagoe, Hajime, Matsushita, Shuzo

“…Administration of convalescent plasma or neutralizing monoclonal antibodies (mAbs) is a potent therapeutic option for coronavirus disease 2019 (COVID-19)…”
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Functional analysis of a monoclonal antibody reactive against the C1C2 of Env obtained from a patient infected with HIV-1 CRF02_AG by Md Zahid, Hasan, Kuwata, Takeo, Takahama, Shokichi, Kaku, Yu, Biswas, Shashwata, Matsumoto, Kaho, Tamamura, Hirokazu, Matsushita, Shuzo

“…Recent data suggest the importance of non-neutralizing antibodies (nnAbs) in the development of vaccines against HIV-1 because two types of nnAbs that…”
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Partial Splenic Embolization in a Patient with Hemophilia A and Severe Thrombocytopenia: A Case Report by Nakamura, Tomofumi, Uchiba, Mitsuhiro, Nakata, Hirotomo, Mizumoto, Takao, Beppu, Toru, Matsushita, Shuzo

“…We report a patient with hemophilia A who underwent partial splenic embolization (PSE) for severe thrombocytopenia secondary to portal hypertension-induced…”
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Flexibility of small molecular CD4 mimics as HIV entry inhibitors by Kobayakawa, Takuya, Ohashi, Nami, Hirota, Yuki, Takahashi, Kohei, Yamada, Yuko, Narumi, Tetsuo, Yoshimura, Kazuhisa, Matsushita, Shuzo, Harada, Shigeyoshi, Tamamura, Hirokazu

“…[Display omitted] CD4 mimics such as YIR-821 and its derivatives are small molecules which inhibit the interaction between the Phe43 cavity of HIV-1 gp120 with…”
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Clonality of HIV-1– and HTLV-1–Infected Cells in Naturally Coinfected Individuals by Katsuya, Hiroo, Cook, Lucy B M, Rowan, Aileen G, Melamed, Anat, Turpin, Jocelyn, Ito, Jumpei, Islam, Saiful, Miyazato, Paola, Jek Yang Tan, Benjy, Matsuo, Misaki, Miyakawa, Toshikazu, Nakata, Hirotomo, Matsushita, Shuzo, Taylor, Graham P, Bangham, Charles R M, Kimura, Shinya, Satou, Yorifumi

“…Abstract Background Coinfection with human immunodeficiency virus type 1 (HIV-1) and human T-cell leukemia virus type 1 (HTLV-1) diminishes the value of the…”
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Apolipoprotein E is an HIV-1-inducible inhibitor of viral production and infectivity in macrophages by Siddiqui, Rokeya, Suzu, Shinya, Ueno, Mikinori, Nasser, Hesham, Koba, Ryota, Bhuyan, Farzana, Noyori, Osamu, Hamidi, Sofiane, Sheng, Guojun, Yasuda-Inoue, Mariko, Hishiki, Takayuki, Sukegawa, Sayaka, Miyagi, Eri, Strebel, Klaus, Matsushita, Shuzo, Shimotohno, Kunitada, Ariumi, Yasuo

“…Apolipoprotein E (ApoE) belongs to a class of cellular proteins involved in lipid metabolism. ApoE is a polymorphic protein produced primarily in macrophages…”
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Impact of maraviroc-resistant and low-CCR5-adapted mutations induced by in vitro passage on sensitivity to anti-envelope neutralizing antibodies by Yoshimura, Kazuhisa, Harada, Shigeyoshi, Boonchawalit, Samatchaya, Kawanami, Yoko, Matsushita, Shuzo

“…The aim of this study was to generate maraviroc (MVC)-resistant viruses in vitro using a human immunodeficiency virus type 1 subtype B clinical isolate…”
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Small-Molecule CD4 Mimics Containing Mono-cyclohexyl Moieties as HIV Entry Inhibitors by Ohashi, Nami, Harada, Shigeyoshi, Mizuguchi, Takaaki, Irahara, Yu, Yamada, Yuko, Kotani, Misato, Nomura, Wataru, Matsushita, Shuzo, Yoshimura, Kazuhisa, Tamamura, Hirokazu

“…CD4 mimics are small molecules that inhibit the protein–protein interaction between gp120 and CD4, which is a key interaction for the entry of human…”
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Enhanced Exposure of Human Immunodeficiency Virus Type 1 Primary Isolate Neutralization Epitopes through Binding of CD4 Mimetic Compounds by Yoshimura, Kazuhisa, Harada, Shigeyoshi, Shibata, Junji, Hatada, Makiko, Yamada, Yuko, Ochiai, Chihiro, Tamamura, Hirokazu, Matsushita, Shuzo

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Phenotypic and Genotypic Co-receptor Tropism Testing in HIV-1 Epidemic Region of Tanzania Where Multiple Non-B Subtypes Co-circulate by Judicate, George P., Barabona, Godfrey, Kamori, Doreen, Mahiti, Macdonald, Tan, Toong Seng, Ozono, Seiya, Mgunya, Amina Shaban, Kuwata, Takeo, Matsushita, Shuzo, Sunguya, Bruno, Lyamuya, Eligius, Tokunaga, Kenzo, Ueno, Takamasa

“…HIV human immunodeficiency virus type I (HIV-1) entry inhibitor potency is dependent on viral co-receptor tropisms and thereby tropism determination is…”
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