Search Results - "Matsushita, Nobuko"

DNA Damage Response Regulation by Histone Ubiquitination by Sekiguchi, Miyu, Matsushita, Nobuko

“…Cells are constantly exposed to numerous genotoxic stresses that induce DNA damage. DNA double-strand breaks (DSBs) are among the most serious damages and…”
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Regulation of Hypoxic Signaling and Oxidative Stress via the MicroRNA-SIRT2 Axis and Its Relationship with Aging-Related Diseases by Kaitsuka, Taku, Matsushita, Masayuki, Matsushita, Nobuko

“…The sirtuin family of nicotinamide adenine dinucleotide-dependent deacetylase and ADP-ribosyl transferases plays key roles in aging, metabolism, stress…”
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MITOL dysfunction causes dwarfism with anterior pituitary hypoplasia by Matsuno, Keigo, Nagashima, Shun, Shiiba, Isshin, Taniwaka, Keito, Takeda, Keisuke, Tokuyama, Takeshi, Ito, Naoki, Matsushita, Nobuko, Fukuda, Toshifumi, Ishido, Satoshi, Inatome, Ryoko, Yanagi, Shigeru

“…In mitochondrial disorders, short stature and growth failure are common symptoms, but their underlying mechanism remains unknown. In this study, we examined…”
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Mitochondrial ubiquitin ligase MITOL ubiquitinates mutant SOD1 and attenuates mutant SOD1-induced reactive oxygen species generation by Yonashiro, Ryo, Sugiura, Ayumu, Miyachi, Misako, Fukuda, Toshifumi, Matsushita, Nobuko, Inatome, Ryoko, Ogata, Yoshinobu, Suzuki, Takehiro, Dohmae, Naoshi, Yanagi, Shigeru

“…We have previously identified a novel mitochondrial ubiquitin ligase, MITOL, which is localized in the mitochondrial outer membrane and is involved in the…”
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Retusone A, a Guaiane-Type Sesquiterpene Dimer from Wikstroemia retusa and Its Inhibitory Effects on Histone Acetyltransferase HBO1 Expression by Yun, Young Sook, Nakano, Tomomi, Fukaya, Haruhiko, Hitotsuyanagi, Yukio, Nakamura, Miho, Umetsu, Megumi, Matsushita, Nobuko, Miyake, Katsunori, Fuchino, Hiroyuki, Kawahara, Nobuo, Moriya, Fuki, Ito, Akihiro, Takahashi, Yuji, Inoue, Hideshi

“…Retusone A ( ), a new sesquiterpene dimer consisting of two guaiane-type sesquiterpenoids, and oleodaphnal ( ) were isolated from heartwood of (Thymelaeaceae)…”
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Modularized Functions of the Fanconi Anemia Core Complex by Huang, Yaling, Leung, Justin W.C., Lowery, Megan, Matsushita, Nobuko, Wang, Yucai, Shen, Xi, Huong, Do, Takata, Minoru, Chen, Junjie, Li, Lei

“…The Fanconi anemia (FA) core complex provides the essential E3 ligase function for spatially defined FANCD2 ubiquitination and FA pathway activation. Of the…”
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Critical role of CRAG, a splicing variant of centaurin-γ3/AGAP3, in ELK1-dependent SRF activation at PML bodies by Nagashima, Shun, Takeda, Keisuke, Shiiba, Isshin, Higashi, Mizuho, Fukuda, Toshifumi, Tokuyama, Takeshi, Matsushita, Nobuko, Nagano, Seiichi, Araki, Toshiyuki, Kaneko, Mari, Shioi, Go, Inatome, Ryoko, Yanagi, Shigeru

“…CRMP-5-associated GTPase (CRAG), a short splicing variant of centaurin-γ3/AGAP3, is predominantly expressed in the developing brain. We previously demonstrated…”
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A mitochondrial ubiquitin ligase MITOL controls cell toxicity of polyglutamine-expanded protein by Sugiura, Ayumu, Yonashiro, Ryo, Fukuda, Toshifumi, Matsushita, Nobuko, Nagashima, Shun, Inatome, Ryoko, Yanagi, Shigeru

“…Expansion of a polyglutamine tract in ataxin-3 (polyQ) causes Machado-Joseph disease, a late-onset neurodegenerative disorder characterized by…”
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MITOL deletion in the brain impairs mitochondrial structure and ER tethering leading to oxidative stress by Nagashima, Shun, Takeda, Keisuke, Ohno, Nobuhiko, Ishido, Satoshi, Aoki, Motohide, Saitoh, Yurika, Takada, Takumi, Tokuyama, Takeshi, Sugiura, Ayumu, Fukuda, Toshifumi, Matsushita, Nobuko, Inatome, Ryoko, Yanagi, Shigeru

“…Mitochondrial abnormalities are associated with developmental disorders, although a causal relationship remains largely unknown. Here, we report that increased…”
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Direct inhibition of TNF-α promoter activity by Fanconi anemia protein FANCD2 by Matsushita, Nobuko, Endo, Yujiro, Sato, Koichi, Kurumizaka, Hitoshi, Yamashita, Takayuki, Takata, Minoru, Yanagi, Shigeru

“…Fanconi anemia (FA), an inherited disease, is associated with progressive bone marrow failure, predisposition to cancer, and genomic instability. Genes…”
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Mitochondrial Dynamics Regulation in Skin Fibroblasts from Mitochondrial Disease Patients by Tokuyama, Takeshi, Hirai, Asei, Shiiba, Isshin, Ito, Naoki, Matsuno, Keigo, Takeda, Keisuke, Saito, Kanata, Mii, Koki, Matsushita, Nobuko, Fukuda, Toshifumi, Inatome, Ryoko, Yanagi, Shigeru

“…Mitochondria are highly dynamic organelles that constantly fuse, divide, and move, and their function is regulated and maintained by their morphologic changes…”
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Regulation of B cell differentiation by the ubiquitin-binding protein TAX1BP1 by Matsushita, Nobuko, Suzuki, Midori, Ikebe, Emi, Nagashima, Shun, Inatome, Ryoko, Asano, Kenichi, Tanaka, Masato, Matsushita, Masayuki, Kondo, Eisaku, Iha, Hidekatsu, Yanagi, Shigeru

“…Tax1-binding protein 1 (TAX1BP1) is a ubiquitin-binding protein that restricts nuclear factor-κB (NF-κB) activation and facilitates the termination of aberrant…”
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Induction of Short NFATc1/αA Isoform Interferes with Peripheral B Cell Differentiation by Muhammad, Khalid, Rudolf, Ronald, Pham, Duong Anh Thuy, Klein-Hessling, Stefan, Takata, Katsuyoshi, Matsushita, Nobuko, Ellenrieder, Volker, Kondo, Eisaku, Serfling, Edgar

“…In lymphocytes, immune receptor signals induce the rapid nuclear translocation of preformed cytosolic NFAT proteins. Along with co-stimulatory signals,…”
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Fanconi Anemia Protein FANCD2 Promotes Immunoglobulin Gene Conversion and DNA Repair through a Mechanism Related to Homologous Recombination by Yamamoto, Kazuhiko, Hirano, Seiki, Ishiai, Masamichi, Morishima, Kenichi, Kitao, Hiroyuki, Namikoshi, Keiko, Kimura, Masayo, Matsushita, Nobuko, Arakawa, Hiroshi, Buerstedde, Jean-Marie, Komatsu, Kenshi, Thompson, Larry H., Takata, Minoru

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Modularized Functions of the Fanconi Anemia Core Complex by Huang, Yaling, Leung, Justin W.C., Lowery, Megan, Matsushita, Nobuko, Wang, Yucai, Shen, Xi, Huong, Do, Takata, Minoru, Chen, Junjie, Li, Lei

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Functional relationships of FANCC to homologous recombination, translesion synthesis, and BLM by Hirano, Seiki, Yamamoto, Kazuhiko, Ishiai, Masamichi, Yamazoe, Mitsuyoshi, Seki, Masayuki, Matsushita, Nobuko, Ohzeki, Mioko, Yamashita, Yukiko M, Arakawa, Hiroshi, Buerstedde, Jean-Marie, Enomoto, Takemi, Takeda, Shunichi, Thompson, Larry H, Takata, Minoru

“…Some of the restarting events of stalled replication forks lead to sister chromatid exchange (SCE) as a result of homologous recombination (HR) repair with…”
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Functional Interplay between BRCA2/FancD1 and FancC in DNA Repair by Kitao, Hiroyuki, Yamamoto, Kazuhiko, Matsushita, Nobuko, Ohzeki, Mioko, Ishiai, Masamichi, Takata, Minoru

“…A rare hereditary disorder, Fanconi anemia (FA), is caused by mutations in an array of genes, which interact in a common FA pathway/network. These genes encode…”
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Fanconi Anemia FANCG Protein in Mitigating Radiation- and Enzyme-Induced DNA Double-Strand Breaks by Homologous Recombination in Vertebrate Cells by Yamamoto, Kazuhiko, Ishiai, Masamichi, Matsushita, Nobuko, Arakawa, Hiroshi, Lamerdin, Jane E., Buerstedde, Jean-Marie, Tanimoto, Mitsune, Harada, Mine, Thompson, Larry H., Takata, Minoru

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Role of NAD‐dependent deacetylases SIRT1 and SIRT2 in radiation and cisplatin‐induced cell death in vertebrate cells by Matsushita, Nobuko, Takami, Yasunari, Kimura, Masayo, Tachiiri, Seiji, Ishiai, Masamichi, Nakayama, Takeo, Takata, Minoru

“…Yeast Sir2 is a nicotinamide adenine dinucleotide (NAD)‐dependent histone deacetylase that plays a central role in transcriptional silencing, chromosomal…”
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Dysregulated histone acetylation causes congenital diseases by Matsushita, Nobuko

“…Epigenetic mechanisms are essential for regulating gene expression, altering chromatin structure, and regulating gene transcription without altering the…”
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