Search Results - "Matsumoto, Rae R"

Pharmacology of dextromethorphan: Relevance to dextromethorphan/quinidine (Nuedexta®) clinical use by Taylor, Charles P, Traynelis, Stephen F, Siffert, Joao, Pope, Laura E, Matsumoto, Rae R

“…Dextromethorphan (DM) has been used for more than 50years as an over-the-counter antitussive. Studies have revealed a complex pharmacology of DM with…”
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Sigma-1 Receptors and Neurodegenerative Diseases: Towards a Hypothesis of Sigma-1 Receptors as Amplifiers of Neurodegeneration and Neuroprotection by Nguyen, Linda, Lucke-Wold, Brandon P, Mookerjee, Shona, Kaushal, Nidhi, Matsumoto, Rae R

“…Sigma-1 receptors are molecular chaperones that may act as pathological mediators and targets for novel therapeutic applications in neurodegenerative diseases…”
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Role of sigma-1 receptors in neurodegenerative diseases by Nguyen, Linda, Lucke-Wold, Brandon P., Mookerjee, Shona A., Cavendish, John Z., Robson, Matthew J., Scandinaro, Anna L., Matsumoto, Rae R.

“…Neurodegenerative diseases with distinct genetic etiologies and pathological phenotypes appear to share common mechanisms of neuronal cellular dysfunction,…”
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Deuterated (d6)-dextromethorphan elicits antidepressant-like effects in mice by Nguyen, Linda, Scandinaro, Anna L., Matsumoto, Rae R.

“…The over-the-counter antitussive dextromethorphan (DM) may have rapid antidepressant actions based on its overlapping pharmacology with ketamine, which has…”
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Involvement of sigma-1 receptors in the antidepressant-like effects of dextromethorphan by Nguyen, Linda, Robson, Matthew J, Healy, Jason R, Scandinaro, Anna L, Matsumoto, Rae R

“…Dextromethorphan is an antitussive with a high margin of safety that has been hypothesized to display rapid-acting antidepressant activity based on…”
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Methamphetamine-induced toxicity: An updated review on issues related to hyperthermia by MATSUMOTO, Rae R, SEMINERIO, Michael J, TURNER, Ryan C, ROBSON, Matthew J, NGUYEN, Linda, MILLER, Diane B, O'CALLAGHAN, James P

“…Reports of methamphetamine-related emergency room visits suggest that elevated body temperature is a universal presenting symptom, with lethal overdoses…”
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Sigma receptors as potential therapeutic targets for neuroprotection by Nguyen, Linda, Kaushal, Nidhi, Robson, Matthew J., Matsumoto, Rae R.

“…Sigma receptors comprise a unique family of proteins that have been implicated in the pathophysiology and treatment of many central nervous system disorders,…”
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Sigma receptors: potential targets for a new class of antidepressant drug by Fishback, James A, Robson, Matthew J, Xu, Yan-Tong, Matsumoto, Rae R

“…Despite the widespread and devastating impact of depression on society, our current understanding of its pathogenesis is limited. Likewise, existing treatments…”
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Sigma-1 receptors: potential targets for the treatment of substance abuse by Robson, Matthew J, Noorbakhsh, Bahar, Seminerio, Michael J, Matsumoto, Rae R

“…Drug abuse is currently a large economic and societal burden in countries around the globe. Many drugs of abuse currently lack adequate therapies aimed at…”
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SN79, a sigma receptor antagonist, attenuates methamphetamine-induced astrogliosis through a blockade of OSMR/gp130 signaling and STAT3 phosphorylation by Robson, Matthew J., Turner, Ryan C., Naser, Zachary J., McCurdy, Christopher R., O'Callaghan, James P., Huber, Jason D., Matsumoto, Rae R.

“…Methamphetamine (METH) exposure results in dopaminergic neurotoxicity in striatal regions of the brain, an effect that has been linked to an increased risk of…”
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Sigma (σ) receptors as potential therapeutic targets to mitigate psychostimulant effects by Matsumoto, Rae R, Nguyen, Linda, Kaushal, Nidhi, Robson, Matthew J

“…Many psychostimulants, including cocaine and methamphetamine, interact with sigma (σ) receptors at physiologically relevant concentrations. The potential…”
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Role of Sigma Receptors in Methamphetamine-Induced Neurotoxicity by Kaushal, Nidhi, Matsumoto, Rae R

“…Methamphetamine (METH) is a widely abused substance world over. Currently, there is no effective pharma- cotherapy to treat its effects. This necessitates…”
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SN79, a sigma receptor ligand, blocks methamphetamine-induced microglial activation and cytokine upregulation by Robson, Matthew J., Turner, Ryan C., Naser, Zachary J., McCurdy, Christopher R., Huber, Jason D., Matsumoto, Rae R.

“…Methamphetamine (METH) abuse is associated with several negative side effects including neurotoxicity in specific brain regions such as the striatum. The…”
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Evaluation of sigma (σ) receptors in the antidepressant-like effects of ketamine in vitro and in vivo by Robson, Matthew J, Elliott, Meenal, Seminerio, Michael J, Matsumoto, Rae R

“…Abstract Ketamine is an NMDA antagonist and dissociative anesthetic that has been shown to display rapid acting and prolonged antidepressant activity in…”
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Sigma1 (σ1) receptor antagonists represent a new strategy against cocaine addiction and toxicity by MAURICE, Tangui, MARTIN-FARDON, Rémi, ROMIEU, Pascal, MATSUMOTO, Rae R

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CM156, a high affinity sigma ligand, attenuates the stimulant and neurotoxic effects of methamphetamine in mice by Kaushal, Nidhi, Seminerio, Michael J., Shaikh, Jamaluddin, Medina, Mark A., Mesangeau, Christophe, Wilson, Lisa L., McCurdy, Christopher R., Matsumoto, Rae R.

“…Methamphetamine (METH) is a highly addictive psychostimulant drug of abuse. Low and high dose administration of METH leads to locomotor stimulation, and…”
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Involvement of AMPA receptors in the antidepressant-like effects of dextromethorphan in mice by Nguyen, Linda, Matsumoto, Rae R.

“…•Dextromethorphan produced antidepressant-like actions in the TST and FST in mice.•CYP2D6 inhibition potentiated the antidepressant-like effects of…”
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Novel sigma (σ) receptor agonists produce antidepressant-like effects in mice by Wang, Jiajia, Mack, Aisha L, Coop, Andrew, Matsumoto, Rae R

“…Abstract Many antidepressant drugs interact with σ receptors and accumulating evidence suggests that these proteins mediate antidepressant-like effects in…”
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The evaluation of AZ66, an optimized sigma receptor antagonist, against methamphetamine-induced dopaminergic neurotoxicity and memory impairment in mice by Seminerio, Michael J., Hansen, Rolf, Kaushal, Nidhi, Zhang, Han-Ting, McCurdy, Christopher R., Matsumoto, Rae R.

“…Sigma (σ) receptors have recently been identified as potential targets for the development of novel therapeutics aimed at mitigating the effects of…”
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Interactions between 3,4-methylenedioxymethamphetamine and σ1 receptors by BRAMMER, Matthew K, GILMORE, Deborah L, MATSUMOTO, Rae R

“…Methamphetamine and 3,4-methylenedioxymethamphetamine (MDMA) are structurally similar and represent a serious and growing health threat. Earlier studies in our…”
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