Search Results - "Matsumoto, Misako"

A distinct role of Riplet-mediated K63-Linked polyubiquitination of the RIG-I repressor domain in human antiviral innate immune responses by Oshiumi, Hiroyuki, Miyashita, Moeko, Matsumoto, Misako, Seya, Tsukasa

“…The innate immune system is essential for controlling viral infections, but several viruses have evolved strategies to escape innate immunity. RIG-I is a…”
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DDX60, a DEXD/H Box Helicase, Is a Novel Antiviral Factor Promoting RIG-I-Like Receptor-Mediated Signaling by Miyashita, Moeko, Oshiumi, Hiroyuki, Matsumoto, Misako, Seya, Tsukasa

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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A Toll-like receptor 3 (TLR3) agonist ARNAX for therapeutic immunotherapy by Seya, Tsukasa, Takeda, Yohei, Matsumoto, Misako

“…Vaccine immunotherapy consisting of tumor antigens combined with an immune-enhancing adjuvant fosters cytotoxic T cell (CTL) proliferation. Clinically, polyI:C…”
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Toll-like receptor 3 recognizes incomplete stem structures in single-stranded viral RNA by Tatematsu, Megumi, Nishikawa, Fumiko, Seya, Tsukasa, Matsumoto, Misako

“…Endosomal Toll-like receptor 3 (TLR3) serves as a sensor of viral infection and sterile tissue necrosis. Although TLR3 recognizes double-stranded RNA, little…”
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Extracellular RNA Sensing by Pattern Recognition Receptors by Tatematsu, Megumi, Funami, Kenji, Seya, Tsukasa, Matsumoto, Misako

“…RNA works as a genome and messenger in RNA viruses, and it sends messages in most of the creatures of the Earth, including viruses, bacteria, fungi, plants,…”
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Toll-Like Receptor 3 Signal in Dendritic Cells Benefits Cancer Immunotherapy by Matsumoto, Misako, Takeda, Yohei, Tatematsu, Megumi, Seya, Tsukasa

“…Pattern recognition receptors (PRRs) play a crucial role in the innate immune system and contribute to host defense against microbial infection. PRR-mediated…”
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Targeting Toll-like receptor 3 in dendritic cells for cancer immunotherapy by Matsumoto, Misako, Takeda, Yohei, Seya, Tsukasa

“…Activation of innate immune system is a key step to develop anti-tumor immunity. Antigen-presenting dendritic cells (DCs) cross-present tumor-associated…”
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Mucosal Immune Response in Nasal-Associated Lymphoid Tissue upon Intranasal Administration by Adjuvants by Takaki, Hiromi, Ichimiya, Shingo, Matsumoto, Misako, Seya, Tsukasa

“…The nasal administration of vaccines directed against diseases caused by upper respiratory tract infections of pathogens, such as the influenza virus, mimics…”
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Aberrant PD-L1 expression through 3′-UTR disruption in multiple cancers by Kataoka, Keisuke, Shiraishi, Yuichi, Takeda, Yohei, Sakata, Seiji, Matsumoto, Misako, Nagano, Seiji, Maeda, Takuya, Nagata, Yasunobu, Kitanaka, Akira, Mizuno, Seiya, Tanaka, Hiroko, Chiba, Kenichi, Ito, Satoshi, Watatani, Yosaku, Kakiuchi, Nobuyuki, Suzuki, Hiromichi, Yoshizato, Tetsuichi, Yoshida, Kenichi, Sanada, Masashi, Itonaga, Hidehiro, Imaizumi, Yoshitaka, Totoki, Yasushi, Munakata, Wataru, Nakamura, Hiromi, Hama, Natsuko, Shide, Kotaro, Kubuki, Yoko, Hidaka, Tomonori, Kameda, Takuro, Masuda, Kyoko, Minato, Nagahiro, Kashiwase, Koichi, Izutsu, Koji, Takaori-Kondo, Akifumi, Miyazaki, Yasushi, Takahashi, Satoru, Shibata, Tatsuhiro, Kawamoto, Hiroshi, Akatsuka, Yoshiki, Shimoda, Kazuya, Takeuchi, Kengo, Seya, Tsukasa, Miyano, Satoru, Ogawa, Seishi

“…Structural variations disrupting the 3′ region of PD-L1 are shown to aid immune evasion in a number of human cancers, including adult T-cell…”
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DDX60 Is Involved in RIG-I-Dependent and Independent Antiviral Responses, and Its Function Is Attenuated by Virus-Induced EGFR Activation by Oshiumi, Hiroyuki, Miyashita, Moeko, Okamoto, Masaaki, Morioka, Yuka, Okabe, Masaru, Matsumoto, Misako, Seya, Tsukasa

“…RIG-I-mediated type I interferon (IFN) production and nuclease-mediated viral RNA degradation are essential for antiviral innate immune responses. DDX60 is an…”
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Endosomal localization of TLR8 confers distinctive proteolytic processing on human myeloid cells by Ishii, Noriko, Funami, Kenji, Tatematsu, Megumi, Seya, Tsukasa, Matsumoto, Misako

“…Nucleic acid-sensing TLRs are involved in both antimicrobial immune responses and autoimmune inflammation. TLR8 is phylogenetically and structurally related to…”
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Functional interfaces between TICAM-2/TRAM and TICAM-1/TRIF in TLR4 signaling by Funami, Kenji, Matsumoto, Misako, Oshiumi, Hiroyuki, Inagaki, Fuyuhiko, Seya, Tsukasa

“…Toll-like receptor 4 (TLR4) recognizes lipopolysaccharide (LPS), produces pro-inflammatory cytokines and type I interferons, and associates with a trigger of…”
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Adjuvant for vaccine immunotherapy of cancer – focusing on Toll‐like receptor 2 and 3 agonists for safely enhancing antitumor immunity by Seya, Tsukasa, Shime, Hiroaki, Takeda, Yohei, Tatematsu, Megumi, Takashima, Ken, Matsumoto, Misako

“…Immune‐enhancing adjuvants usually targets antigen (Ag)‐presenting cells to tune up cellular and humoral immunity. CD141+ dendritic cells (DC) represent the…”
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Antiviral responses induced by the TLR3 pathway by Matsumoto, Misako, Oshiumi, Hiroyuki, Seya, Tsukasa

“…Antiviral responses are successively induced in virus‐infected animals, and include primary innate immune responses such as type I interferon (IFN) and…”
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A TLR3-Specific Adjuvant Relieves Innate Resistance to PD-L1 Blockade without Cytokine Toxicity in Tumor Vaccine Immunotherapy by Takeda, Yohei, Kataoka, Keisuke, Yamagishi, Junya, Ogawa, Seishi, Seya, Tsukasa, Matsumoto, Misako

“…Cancer patients having anti-programmed cell death-1 (PD-1)/PD ligand 1 (L1)-unresponsive tumors may benefit from advanced immunotherapy. Double-stranded RNA…”
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Toll-like receptor 3 signaling converts tumor-supporting myeloid cells to tumoricidal effectors by Shime, Hiroaki, Matsumoto, Misako, Oshiumi, Hiroyuki, Tanaka, Shinya, Nakane, Akio, Iwakura, Yoichiro, Tahara, Hideaki, Inoue, Norimitsu, Seya, Tsukasa

“…Smoldering inflammation often increases the risk of progression for malignant tumors and simultaneously matures myeloid dendritic cells (mDCs) for…”
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STING in tumor and host cells cooperatively work for NK cell-mediated tumor growth retardation by Takashima, Ken, Takeda, Yohei, Oshiumi, Hiroyuki, Shime, Hiroaki, Okabe, Masaru, Ikawa, Masahito, Matsumoto, Misako, Seya, Tsukasa

“…An interferon-inducing DNA sensor STING participates in tumor rejection in mouse models. Here we examined what mechanisms contribute to STING-dependent growth…”
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RIOK3-Mediated Phosphorylation of MDA5 Interferes with Its Assembly and Attenuates the Innate Immune Response by Takashima, Ken, Oshiumi, Hiroyuki, Takaki, Hiromi, Matsumoto, Misako, Seya, Tsukasa

“…MDA5 is a cytoplasmic viral double-stranded RNA (dsRNA) sensor and triggers type I interferon (IFN) production. MDA5 assembles along viral dsRNA, leading to…”
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Epstein-Barr virus (EBV)-encoded small RNA is released from EBV-infected cells and activates signaling from Toll-like receptor 3 by Iwakiri, Dai, Zhou, Li, Samanta, Mrinal, Matsumoto, Misako, Ebihara, Takashi, Seya, Tsukasa, Imai, Shosuke, Fujieda, Mikiya, Kawa, Keisei, Takada, Kenzo

“…Epstein-Barr virus-encoded small RNA (EBER) is nonpolyadenylated, noncoding RNA that forms stem-loop structure by intermolecular base-pairing, giving rise to…”
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Teleost TLR22 Recognizes RNA Duplex to Induce IFN and Protect Cells from Birnaviruses by Matsuo, Aya, Oshiumi, Hiroyuki, Tsujita, Tadayuki, Mitani, Hiroshi, Kasai, Hisae, Yoshimizu, Mamoru, Matsumoto, Misako, Seya, Tsukasa

“…TLR22 occurs exclusively in aquatic animals and its role is unknown. Herein we show that the fugu (Takifugu rubripes) (fg)TLR3 and fgTLR22 link the…”
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