Clinical and Vitamin Response to a Short‐Term Multi‐Micronutrient Intervention in Brazilian Children and Teens: From Population Data to Interindividual Responses

Scope Micronutrients are in small amounts in foods, act in concert, and require variable amounts of time to see changes in health and risk for disease. These first principles are incorporated into an intervention study designed to develop new experimental strategies for setting target recommendation...

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Published in:	Molecular nutrition & food research Vol. 62; no. 6; pp. e1700613 - n/a
Main Authors:	Mathias, Mariana Giaretta, Coelho‐Landell, Carolina de Almeida, Scott‐Boyer, Marie‐Pier, Lacroix, Sébastien, Morine, Melissa J., Salomão, Roberta Garcia, Toffano, Roseli Borges Donegá, Almada, Maria Olímpia Ribeiro do Vale, Camarneiro, Joyce Moraes, Hillesheim, Elaine, Barros, Tamiris Trevisan, Camelo‐Junior, José Simon, Campos Giménez, Esther, Redeuil, Karine, Goyon, Alexandre, Bertschy, Emmanuelle, Lévêques, Antoine, Oberson, Jean‐Marie, Giménez, Catherine, Carayol, Jerome, Kussmann, Martin, Descombes, Patrick, Métairon, Slyviane, Draper, Colleen Fogarty, Conus, Nelly, Mottaz, Sara Colombo, Corsini, Giovanna Zambianchi, Myoshi, Stephanie Kazu Brandão, Muniz, Mariana Mendes, Hernandes, Lívia Cristina, Venâncio, Vinícius Paula, Antunes, Lusania Maria Greggi, da Silva, Rosana Queiroz, Laurito, Taís Fontellas, Rossi, Isabela Ribeiro, Ricci, Raquel, Jorge, Jéssica Ré, Fagá, Mayara Leite, Quinhoneiro, Driele Cristina Gomes, Reche, Mariana Chinarelli, Silva, Paula Vitória Sozza, Falquetti, Letícia Lima, da Cunha, Thaís Helena Alves, Deminice, Thalia Manfrin Martins, Tambellini, Tâmara Hambúrguer, Souza, Gabriela Cristina Arces, Oliveira, Mariana Moraes, Nogueira‐Pileggi, Vicky, Matsumoto, Marina Takemoto, Priami, Corrado, Kaput, Jim, Monteiro, Jacqueline Pontes
Format:	Journal Article
Language:	English
Published:	Germany Wiley Subscription Services, Inc 01-03-2018 John Wiley and Sons Inc
Subjects:	Adolescent Anthropometry Child Children community‐based participatory research Computer applications Dyslipidemias - blood Feeding Behavior Female First principles Food Food intake Health risks Humans Individuality Intervention Male metabolic health Micronutrients Micronutrients - administration & dosage Modulus of elasticity Parameters Participatory research Regression analysis Regression models targeted and systems nutrition Vitamins Vitamins - blood Young adults metabolic health micronutrients targeted and systems nutrition community-based participatory research
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Summary:	Scope Micronutrients are in small amounts in foods, act in concert, and require variable amounts of time to see changes in health and risk for disease. These first principles are incorporated into an intervention study designed to develop new experimental strategies for setting target recommendations for food bioactives for populations and individuals. Methods and results A 6‐week multivitamin/mineral intervention is conducted in 9–13 year olds. Participants (136) are (i) their own control (n‐of‐1); (ii) monitored for compliance; (iii) measured for 36 circulating vitamin forms, 30 clinical, anthropometric, and food intake parameters at baseline, post intervention, and following a 6‐week washout; and (iv) had their ancestry accounted for as modifier of vitamin baseline or response. The same intervention is repeated the following year (135 participants). Most vitamins respond positively and many clinical parameters change in directions consistent with improved metabolic health to the intervention. Baseline levels of any metabolite predict its own response to the intervention. Elastic net penalized regression models are identified, and significantly predict response to intervention on the basis of multiple vitamin/clinical baseline measures. Conclusions The study design, computational methods, and results are a step toward developing recommendations for optimizing vitamin levels and health parameters for individuals. Identical 6‐week multivitamin/mineral interventions are conducted in successive years in adolescents. Data are aggregated for population level analysis and for individual responses. Most levels of plasma vitamins respond positively and many clinical parameters change in directions consistent with improved metabolic health to the intervention. Elastic net models significantly predict response to intervention on the basis of multiple vitamin/clinical baseline measures.
Bibliography:	Present address: Vinícius Paula Venâncio, Department of Nutrition and Food Science, Texas A&M. College Station Texas Present address: Nelly Conus, Bayer Consumer Care AG, Basel, Switzerland Present address: Jim Kaput, Vydiant, Gold River, CA 95670 Present address: Sébastien Lacroix, Institut sur la Nutrition et les Aliments Fonctionnels (INAF), Université Laval, Québec, Canada Present address: Martin Kussmann, Liggins Institute, University of Auckland, New Zealand Present address: Marie‐Pier Scott‐Boyer, University of Laval, Quebec Canada Present address: Corrado Priami. Department of Computer Science, University of Pisa, Italy ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1613-4125 1613-4133 1613-4133
DOI:	10.1002/mnfr.201700613