Metastatic Pleomorphic Carcinoma of the Lung with Extensive Chromosomal Rearrangements: An Autopsy Case with a Literature Review

We herein report a 47-year-old man who presented with progressive paraparesis. Imaging revealed a right upper pulmonary nodule, massive bilateral adrenal metastases, thoracolumbar vertebral osteolysis, and subcutaneous nodules. A biopsy of the right buttock nodule revealed a poorly differentiated me...

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Bibliographic Details
Published in:	Internal Medicine p. 3478-24
Main Authors:	Matsumoto, Fukuko, Adachi, Michiko Matsuzawa, Yoshida, Katsuyuki, Yamashita, Takeshi, Shiihara, Jun, Fukuchi, Takahiko, Morikawa, Haruka, Hiruta, Masahiko, Tanno, Keisuke, Oyama-Manabe, Noriko, Oshiro, Hisashi, Sugawara, Hitoshi
Format:	Journal Article
Language:	English
Published:	Japan The Japanese Society of Internal Medicine 2024
Subjects:	driver oncogenes extensive chromosomal rearrangement high programmed cell death-ligand 1 expression immune checkpoint inhibitors massive bilateral adrenal metastases pleomorphic carcinoma of the lung driver oncogenes immune checkpoint inhibitors extensive chromosomal rearrangement high programmed cell death-ligand 1 expression massive bilateral adrenal metastases pleomorphic carcinoma of the lung
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Summary:	We herein report a 47-year-old man who presented with progressive paraparesis. Imaging revealed a right upper pulmonary nodule, massive bilateral adrenal metastases, thoracolumbar vertebral osteolysis, and subcutaneous nodules. A biopsy of the right buttock nodule revealed a poorly differentiated metastatic carcinoma with high programmed cell death-ligand 1 expression and extensive chromosomal rearrangements. The patient died 10 days after the initiation of pembrolizumab treatment. Autopsy findings confirmed pulmonary pleomorphic carcinoma with extensive metastases. Quantification of chromosomal rearrangements revealed a jump-up mutation from the normal karyotype, followed by a further incremental increase in the degree of deviation.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0918-2918 1349-7235 1349-7235
DOI:	10.2169/internalmedicine.3478-24