Search Results - "Matsumaru, Daisuke"

The KEAP1-NRF2 System in Healthy Aging and Longevity by Matsumaru, Daisuke, Motohashi, Hozumi

“…Aging is inevitable, but the inherently and genetically programmed aging process is markedly influenced by environmental factors. All organisms are constantly…”
Get full text

From germ cells to neonates: the beginning of life and the KEAP1–NRF2 system by Matsumaru, Daisuke, Motohashi, Hozumi

“…Abstract The Kelch-like ECH-associated protein 1(KEAP1)–NF-E2-related factor 2 (NRF2) system is one of the most studied environmental stress response systems…”
Get full text

Enhancer remodeling promotes tumor-initiating activity in NRF2-activated non-small cell lung cancers by Okazaki, Keito, Anzawa, Hayato, Liu, Zun, Ota, Nao, Kitamura, Hiroshi, Onodera, Yoshiaki, Alam, Md. Morshedul, Matsumaru, Daisuke, Suzuki, Takuma, Katsuoka, Fumiki, Tadaka, Shu, Motoike, Ikuko, Watanabe, Mika, Hayasaka, Kazuki, Sakurada, Akira, Okada, Yoshinori, Yamamoto, Masayuki, Suzuki, Takashi, Kinoshita, Kengo, Sekine, Hiroki, Motohashi, Hozumi

“…Transcriptional dysregulation, which can be caused by genetic and epigenetic alterations, is a fundamental feature of many cancers. A key cytoprotective…”
Get full text

Evaluation of the Estrogenic Action Potential of Royal Jelly by Genomic Signaling Pathway in Vitro and in Vivo by Ishida, Keishi, Matsumaru, Daisuke, Shimizu, Shinya, Hiromori, Youhei, Nagase, Hisamitsu, Nakanishi, Tsuyoshi

“…Royal jelly (RJ) has beneficial effects on human health, and some of these effects are reported to be the result of its estrogenic activity; however, chemicals…”
Get full text

NRF2 pathway activation by KEAP1 inhibition attenuates the manifestation of aging phenotypes in salivary glands by Wati, Sisca Meida, Matsumaru, Daisuke, Motohashi, Hozumi

“…Saliva plays an essential role in the maintenance of oral health. The oral cavity environment changes during aging mainly due to alterations in the secretion…”
Get full text

NRF2 pathway activation attenuates ageing-related renal phenotypes due to α-klotho deficiency by Zhao, Mingyue, Murakami, Shohei, Matsumaru, Daisuke, Kawauchi, Takeshi, Nabeshima, Yo-ichi, Motohashi, Hozumi

“…Abstract Oxidative stress is one of the major causes of the age-related functional decline in cells and tissues. The KEAP1–NRF2 system plays a central role in…”
Get full text

The role of p63 in embryonic external genitalia outgrowth in mice by Tanaka, Kosei, Matsumaru, Daisuke, Suzuki, Kentaro, Yamada, Gen, Miyagawa, Shinichi

“…Embryonic external genitalia (genital tubercle [GT]) protrude from the cloaca and outgrow as cloacal development progresses. Individual gene functions and…”
Get full text

Novel, highly sensitive, in vivo screening method detects estrogenic activity at low doses of bisphenol A by Ishida, Keishi, Furukawa, Motoshi, Kunitani, Masataka, Yamagiwa, Rai, Hiromori, Youhei, Matsumaru, Daisuke, Hu, Jianying, Nagase, Hisamitsu, Nakanishi, Tsuyoshi

“…Low doses of bisphenol A (BPA), a typical endocrine-disrupting chemical (EDC), have been reported to exhibit estrogenic action in animals; however, the effects…”
Get full text

Triphenyl phosphate delayed pubertal timing and induced decline of ovarian reserve in mice as an estrogen receptor antagonist by Ma, Haojia, Ishida, Keishi, Xu, Chenke, Takahashi, Kyosuke, Li, Yu, Zhang, Chenhao, Kang, Qiyue, Jia, Yingting, Hu, Wenxin, Matsumaru, Daisuke, Nakanishi, Tsuyoshi, Hu, Jianying

“…Although concerns have been raised about the adverse effects of triphenyl phosphate (TPhP) on female fertility, its risk to ovarian functioning remains…”
Get full text

Neuronal differentiation reporter mice as a new methodology for detecting in vivo developmental neurotoxicity by Ishida, Keishi, Tatsumi, Kanoko, Minamigawa, Yoshiki, Mori, Kazuma, Matsumaru, Daisuke, Nagase, Hisamitsu, Kanda, Yasunari, Takuma, Kazuhiro, Nakanishi, Tsuyoshi

“…[Display omitted] Current in vivo developmental neurotoxicity (DNT) tests are not performed routinely for chemical risk assessment because they are time and…”
Get full text

Evaluation of surgical procedures of mouse urethra by visualization and the formation of fistula by Hyuga, Taiju, Hashimoto, Daiki, Matsumaru, Daisuke, Kumegawa, Shinji, Asamura, Shinichi, Suzuki, Kentaro, Katayama, Kei-ichi, Nakamura, Shigeru, Nakai, Hideo, Yamada, Gen

“…Visualization of the surgically operated tissues is vital to improve surgical model animals including mouse. Urological surgeries for urethra include series of…”
Get full text

Evaluation of the Skin-Sensitizing Potential of Brazilian Green Propolis by Shiraishi, Erina, Ishida, Keishi, Matsumaru, Daisuke, Ido, Akiko, Hiromori, Youhei, Nagase, Hisamitsu, Nakanishi, Tsuyoshi

“…Propolis is a resinous mixture produced by bees from their secretions and plant material, so its composition varies depending on its botanical origin. Propolis…”
Get full text

New Insights into Development of Female Reproductive Tract-Hedgehog-Signal Response in Wolffian Tissues Directly Contributes to Uterus Development by Haraguchi, Ryuma, Yamada, Gen, Murashima, Aki, Matsumaru, Daisuke, Kitazawa, Riko, Kitazawa, Sohei

“…The reproductive tract in mammals emerges from two ductal systems during embryogenesis: Wolffian ducts (WDs) and Mullerian ducts (MDs). Most of the female…”
Get full text

Gli3 is a Key Factor in the Schwann Cells from Both Intact and Injured Peripheral Nerves by Yamada, Yurie, Trakanant, Supaluk, Nihara, Jun, Kudo, Takehisa, Seo, Kenji, Saeki, Makio, Kurose, Masayuki, Matsumaru, Daisuke, Maeda, Takeyasu, Ohazama, Atsushi

“…•Repressor form of Gli3 suppress Hh signaling in Schwann cells of intact peripheral nerve.•After nerve injury, repressor form of Gli3 in Schwann cells is…”
Get full text

Publisher Correction: Enhancer remodeling promotes tumor-initiating activity in NRF2-activated non-small cell lung cancers by Okazaki, Keito, Anzawa, Hayato, Liu, Zun, Ota, Nao, Kitamura, Hiroshi, Onodera, Yoshiaki, Alam, Md. Morshedul, Matsumaru, Daisuke, Suzuki, Takuma, Katsuoka, Fumiki, Tadaka, Shu, Motoike, Ikuko, Watanabe, Mika, Hayasaka, Kazuki, Sakurada, Akira, Okada, Yoshinori, Yamamoto, Masayuki, Suzuki, Takashi, Kinoshita, Kengo, Sekine, Hiroki, Motohashi, Hozumi

“…A Correction to this paper has been published: https://doi.org/10.1038/s41467-021-20927-9…”
Get full text

Skeletal muscle-specific Keap1 disruption modulates fatty acid utilization and enhances exercise capacity in female mice by Onoki, Takahiro, Izumi, Yoshihiro, Takahashi, Masatomo, Murakami, Shohei, Matsumaru, Daisuke, Ohta, Nao, Wati, Sisca Meida, Hatanaka, Nozomi, Katsuoka, Fumiki, Okutsu, Mitsuharu, Yabe, Yutaka, Hagiwara, Yoshihiro, Kanzaki, Makoto, Bamba, Takeshi, Itoi, Eiji, Motohashi, Hozumi

“…Skeletal muscle health is important for the prevention of various age-related diseases. The loss of skeletal muscle mass, which is known as sarcopenia,…”
Get full text

Progenitor Cell Expansion and Organ Size of Mouse Adrenal Is Regulated by Sonic Hedgehog by Huang, Chen-Che Jeff, Miyagawa, Shinichi, Matsumaru, Daisuke, Parker, Keith L, Yao, Humphrey Hung-Chang

“…The adrenal capsule is postulated to harbor stem/progenitor cells, the progenies of which contribute to the growth of adrenocortex. We discovered that cells in…”
Get full text

Alginate-coated activated charcoal enhances fecal excretion of 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice, with fewer side effects than uncoated one by Dungkokkruad, Pinyapach, Tomita, Shunsuke, Hiromori, Youhei, Ishida, Keishi, Matsumaru, Daisuke, Mekada, Kyoko, Nagase, Hisamitsu, Tanaka, Keiichi, Nakanishi, Tsuyoshi

“…Activated charcoal (AC) is a potential candidate antidote against dioxins. However, it is difficult to take AC as a supplement on a daily basis, because its…”
Get full text

The hedgehog signal induced modulation of bone morphogenetic protein signaling: an essential signaling relay for urinary tract morphogenesis by Haraguchi, Ryuma, Matsumaru, Daisuke, Nakagata, Naomi, Miyagawa, Shinichi, Suzuki, Kentaro, Kitazawa, Sohei, Yamada, Gen

“…Congenital diseases of the urinary tract are frequently observed in infants. Such diseases present a number of developmental anomalies such as hydroureter and…”
Get full text

Tri-substituted organotin compounds, but not retinoic acid, are potent ligands of complement component 8 γ by Yamamoto, Katsuya, Hiromori, Youhei, Matsumaru, Daisuke, Ishii, Yoichiro, Takeshita, Yuki, Tsubakihara, Iori, Kimura, Tomoki, Nagase, Hisamitsu, Nakanishi, Tsuyoshi

“…Complement component 8 γ (C8γ) is a subunit of complement protein 8 (C8), which itself is a subunit of the complement cytolytic membrane attack complex…”
Get full text