Search Results - "Matsudaira, Paul"

Desorption-Mediated Motion of Nanoparticles at the Liquid–Solid Interface by Chee, See Wee, Baraissov, Zhaslan, Loh, N. Duane, Matsudaira, Paul T, Mirsaidov, Utkur

“…Nanoparticles (NPs) confined in thin layers of liquid within liquid cells used for in situ transmission electron microscopy (TEM) move very slowly, in contrast…”
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Strain maps characterize the symmetry of convergence and extension patterns during zebrafish gastrulation by Bhattacharya, Dipanjan, Zhong, Jun, Tavakoli, Sahar, Kabla, Alexandre, Matsudaira, Paul

“…During gastrulation of the zebrafish embryo, the cap of blastoderm cells organizes into the axial body plan of the embryo with left–right symmetry and…”
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Migration of Tumor Cells in 3D Matrices Is Governed by Matrix Stiffness along with Cell-Matrix Adhesion and Proteolysis by Zaman, Muhammad H., Trapani, Linda M., Siemeski, Alisha, MacKellar, Drew, Gong, Haiyan, Kamm, Roger D., Wells, Alan, Lauffenburger, Douglas A., Matsudaira, Paul

“…Cell migration on 2D surfaces is governed by a balance between counteracting tractile and adhesion forces. Although biochemical factors such as adhesion…”
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Imaging Protein Structure in Water at 2.7 nm Resolution by Transmission Electron Microscopy by Mirsaidov, Utkur M., Zheng, Haimei, Casana, Yosune, Matsudaira, Paul

“…We demonstrate an in situ transmission electron microscopy technique for imaging proteins in liquid water at room temperature. Liquid samples are loaded into a…”
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Wnt3 distribution in the zebrafish brain is determined by expression, diffusion and multiple molecular interactions by Veerapathiran, Sapthaswaran, Teh, Cathleen, Zhu, Shiwen, Kartigayen, Indira, Korzh, Vladimir, Matsudaira, Paul T, Wohland, Thorsten

“…Wnt3 proteins are lipidated and glycosylated signaling molecules that play an important role in zebrafish neural patterning and brain development. However, the…”
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Morphological and molecular evidence for functional organization along the rostrocaudal axis of the adult zebrafish intestine by Wang, Zhengyuan, Du, Jianguo, Lam, Siew Hong, Mathavan, Sinnakarupan, Matsudaira, Paul, Gong, Zhiyuan

“…The zebrafish intestine is a simple tapered tube that is folded into three sections. However, whether the intestine is functionally similar along its length…”
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Direct observation of stick-slip movements of water nanodroplets induced by an electron beam by Mirsaidov, Utkur M., Zheng, Haimei, Bhattacharya, Dipanjan, Casana, Yosune, Matsudaira, Paul

“…Dynamics of the first few nanometers of water at the interface are encountered in a wide range of physical, chemical, and biological phenomena. A simple but…”
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Electron Beam Manipulation of Nanoparticles by Zheng, Haimei, Mirsaidov, Utkur M, Wang, Lin-Wang, Matsudaira, Paul

“…We report on electron beam manipulation and simultaneous transmission electron microscopy imaging of gold nanoparticle movements in an environmental cell…”
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Biochemical and structural characterization of a recombinant fibrinogen-related lectin from Penaeus monodon by Singrang, Nongnuch, Laophetsakunchai, Sirasit, Tran, Bich Ngoc, Matsudaira, Paul T., Tassanakajon, Anchalee, Wangkanont, Kittikhun

“…Fibrinogen-related lectins are carbohydrate-binding proteins of the innate immune system that recognize glycan structures on microbial surfaces. These innate…”
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Direct measurement of Vorticella contraction force by micropipette deflection by France, Danielle, Tejada, Jonathan, Matsudaira, Paul

“…The ciliated protozoan Vorticella convallaria is noted for its exceptionally fast adenosine triphosphate‐independent cellular contraction, but direct…”
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Cell clusters containing intestinal stem cells, line the zebrafish intestine intervillus pocket by Tavakoli, Sahar, Zhu, Shiwen, Matsudaira, Paul

“…In the mammalian intestine, stem cells (ISCs) replicate in basal crypts, translocate along the villus, and undergo cell death. This pattern of renewal occurs…”
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The degradation-promoting roles of deubiquitinases Ubp6 and Ubp3 in cytosolic and ER protein quality control by Wu, Hongyi, Ng, Davis T W, Cheong, Ian, Matsudaira, Paul

“…The quality control of intracellular proteins is achieved by degrading misfolded proteins which cannot be refolded by molecular chaperones. In eukaryotes, such…”
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Tension, free space, and cell damage in a microfluidic wound healing assay by Murrell, Michael, Kamm, Roger, Matsudaira, Paul

“…We use a novel, microfluidics-based technique to deconstruct the classical wound healing scratch assay, decoupling the contribution of free space and cell…”
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Genetic Selection Based on a Ste6C-HA-Ura3 Substrate Identifies New Cytosolic Quality Control Alleles in Saccharomyces cerevisiae by Chan, Shu Ning, Prasad, Rupali, Matsudaira, Paul

“…Protein quality control in the cytosol (CytoQC) is an important cellular pathway consisting of a network of components which monitor the folding of cytosolic…”
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Fluid dynamic estimation of the effective spring constant of the relaxing stalk of Vorticella convallaria by Ryu, Sangjin, Matsudaira, Paul

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Epithelial Monolayers Coalesce on a Viscoelastic Substrate through Redistribution of Vinculin by Zheng, Ji Yun, Han, Siew Ping, Chiu, Yi-Jen, Yip, Ai Kia, Boichat, Nicolas, Zhu, Shi Wen, Zhong, Jun, Matsudaira, Paul

“…The mechanical properties of the microenvironment play a large role in influencing cellular behavior. In particular, the tradeoff between substrate viscosity…”
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Unsteady Motion, Finite Reynolds Numbers, and Wall Effect on Vorticella convallaria Contribute Contraction Force Greater than the Stokes Drag by Ryu, Sangjin, Matsudaira, Paul

“…Contraction of Vorticella convallaria, a sessile ciliated protozoan, is completed within a few milliseconds and results in a retraction of its cell body toward…”
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Nucleic acid and protein mass mapping by live-cell deep-ultraviolet microscopy by Zeskind, Benjamin J, Jordan, Caroline D, Timp, Winston, Trapani, Linda, Waller, Guichy, Horodincu, Victor, Ehrlich, Daniel J, Matsudaira, Paul

“…We developed a deep-ultraviolet (UV) microscope capable of imaging cell mitosis and motility at 280 nm for 45 min with minimal UV-induced toxicity, and for 6 h…”
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Live cell lithography: using optical tweezers to create synthetic tissue by Mirsaidov, Utkur, Scrimgeour, Jan, Timp, Winston, Beck, Kaethe, Mir, Mustafa, Matsudaira, Paul, Timp, Gregory

“…We demonstrate a new method for creating synthetic tissue that has the potential to capture the three-dimensional (3D) complexity of a multi-cellular organism…”
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A Collagen10a1 mutation disrupts cell polarity in a medaka model for metaphyseal chondrodysplasia type Schmid by Tan, Wen Hui, Rücklin, Martin, Larionova, Daria, Ngoc, Tran Bich, Joan van Heuven, Bertie, Marone, Federica, Matsudaira, Paul, Winkler, Christoph

“…Heterozygous mutations in COL10A1 lead to metaphyseal chondrodysplasia type Schmid (MCDS), a skeletal disorder characterized by epiphyseal abnormalities. Prior…”
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