Treatment with probiotics in experimental oral colonization by Candida albicans in murine model (DBA/2)

Oral Diseases (2012) 18, 260–264 The aim of this study is to evaluate the oral colonization by Candida albicans in experimental murine immunosuppressed DBA/2 and treatment with probiotic bacteria. To achieve these objectives, 152 DBA/2‐immunosuppressed mice were orally inoculated with a suspension o...

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Published in:	Oral diseases Vol. 18; no. 3; pp. 260 - 264
Main Authors:	Matsubara, VH, Silva, EG, Paula, CR, Ishikawa, KH, Nakamae, AEM
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 01-04-2012 Wiley Subscription Services, Inc
Subjects:	Animal models Animals Antifungal Agents - therapeutic use Candida - isolation & purification Candida albicans Candidiasis, Oral - drug therapy Candidiasis, Oral - therapy Colonization Colony Count, Microbial Cyclophosphamide - administration & dosage Dentistry Disease Models, Animal Immunosuppression Immunosuppressive Agents - administration & dosage Inoculation Lactobacillus acidophilus Lactobacillus rhamnosus Male Mice Mice, Inbred DBA Mouth Mucosa - microbiology Mucosa Nystatin Nystatin - therapeutic use oral candidiasis Palate - microbiology probiotics Probiotics - therapeutic use Random Allocation Tongue - microbiology
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Summary:	Oral Diseases (2012) 18, 260–264 The aim of this study is to evaluate the oral colonization by Candida albicans in experimental murine immunosuppressed DBA/2 and treatment with probiotic bacteria. To achieve these objectives, 152 DBA/2‐immunosuppressed mice were orally inoculated with a suspension of C. albicans containing 108 viable yeast cells, the animals were treated with nystatin or with the probiotics (Lactobacillus acidophilus and Lactobacillus rhamnosus). Evaluations were performed by Candida count from oral mucosa swabbing. The oral mucosa colonization by C. albicans started at day 1 after inoculation, remained maximal from day 3 until day 7, and then decreased significantly. Probiotics reduced the C. albicans colonization significantly on the oral mucosa in comparison with the untreated animal group. In the group treated with L. rhamnosus, the reduction in yeast colonization was significantly higher compared with that of the group receiving nystatin. Immunosuppressed animal model DBA/2 is a relevant model for experimental Candida oral colonization, and the treatment with probiotics in this model may be an effective alternative to prevent it.
Bibliography:	istex:87B045F7B05566361C4C15DB511D15C0A3EF6063 ArticleID:ODI1868 ark:/67375/WNG-J2SLML2Z-3 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	1354-523X 1601-0825
DOI:	10.1111/j.1601-0825.2011.01868.x