Search Results - "Matsubara, Toshiya"
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Characterization of different-sized human αA-crystallin homomers and implications to Asp151 isomerization
Published in PloS one (11-07-2024)“…Site-specific modifications of aspartate residues spontaneously occur in crystallin, the major protein in the lens. One of the primary modification sites is…”
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2
Glutamate Acts as a Key Signal Linking Glucose Metabolism to Incretin/cAMP Action to Amplify Insulin Secretion
Published in Cell reports (Cambridge) (23-10-2014)“…Incretins, hormones released by the gut after meal ingestion, are essential for maintaining systemic glucose homeostasis by stimulating insulin secretion. The…”
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3
Establishment of a Triple Quadrupole HPLC-MS Quantitation Method for Dystrophin Protein in Mouse and Human Skeletal Muscle
Published in International journal of molecular sciences (25-12-2023)“…Duchenne muscular dystrophy (DMD) is the most common type of neuromuscular disease caused by mutations in the gene encoding dystrophin protein. To quantitively…”
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Simultaneous and Rapid Detection of Multiple Epimers and Isomers of Aspartyl Residues in Lens Proteins Using an LC-MS-MRM Method
Published in ACS omega (27-10-2020)“…Traditionally, studies of post translational modifications (PTMs) by mass analysis have been limited to modifications such as deamidation and oxidation that…”
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Identification of putative biomarkers for prediabetes by metabolome analysis of rat models of type 2 diabetes
Published in Metabolomics (2015)“…Biomarkers for the development of type 2 diabetes (T2D) are useful for prediction and intervention of the disease at earlier stages. In this study, we…”
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6
Proteomic analysis of slow- and fast-twitch skeletal muscles
Published in Proteomics (Weinheim) (01-07-2005)“…Skeletal muscles are composed of slow‐ and fast‐twitch muscle fibers, which have high potential in aerobic and anaerobic ATP production, respectively. To…”
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7
Quantitative proteomic analysis to discover potential diagnostic markers and therapeutic targets in human renal cell carcinoma
Published in Proteomics (Weinheim) (01-08-2008)“…Renal cell carcinoma (RCC) is relatively resistant to chemotherapy and radiotherapy. Recent advances in drug development are providing novel agents for the…”
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8
Evidence for phosphorylation of rat liver glucose-regulated protein 58, GRP58/ERp57/ER-60, induced by fasting and leptin
Published in FEBS letters (09-01-2006)“…Glucose-regulated protein 58 (GRP58)-like immunoreactivity in rat liver obtained in the evening or after fasting underwent an electrophoretic band-shift, which…”
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An application of the 2-nitrobenzenesulfenyl method to proteomic profiling of human colorectal carcinoma: A novel approach for biomarker discovery
Published in Proteomics. Clinical applications (01-06-2008)“…In the development of novel biomarkers, the proteomic approach is advantageous because using it the cancer‐associated proteins can be directly identified. We…”
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10
Characterization of different-sized human [alpha]A-crystallin homomers and implications to Asp151 isomerization
Published in PloS one (11-07-2024)“…Site-specific modifications of aspartate residues spontaneously occur in crystallin, the major protein in the lens. One of the primary modification sites is…”
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11
Negative charge at aspartate 151 is important for human lens αA-crystallin stability and chaperone function
Published in Experimental eye research (01-05-2019)“…Aggregation of lens protein is a major cause of senile cataract. Lens crystallins contain many kinds of modification that accumulate over lifespan. In…”
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12
Asp isomerization increases aggregation of α-crystallin and decreases its chaperone activity in human lens of various ages
Published in Biochimica et biophysica acta. Proteins and proteomics (01-09-2020)“…α-Crystallin, comprising 40–50 subunits of αA- and αB-subunits, is a long-lived major soluble chaperone protein in lens. During aging, α-crystallin forms…”
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13
PGRN is a Key Adipokine Mediating High Fat Diet-Induced Insulin Resistance and Obesity through IL-6 in Adipose Tissue
Published in Cell metabolism (04-01-2012)“…Adipose tissue secretes adipokines that mediate insulin resistance, a characteristic feature of obesity and type 2 diabetes. By differential proteome analysis…”
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14
Response to Dupuis, Petersen, and Weydt
Published in Cell metabolism (07-03-2012)Get full text
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DEVELOPMENT OF A NOVEL BLOOD-BASED DIAGNOSTIC SYSTEM FOR MILD COGNITIVE IMPAIRMENT AND ALZHEIMER'S DISEASE USING CIRCULATING PEPTIDES
Published in Alzheimer's & dementia (01-07-2017)Get full text
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16
Addition of New Pinning Center to Unidirectionally Melt Solidified Y-Ba-Cu-O Superconductor
Published in Japanese Journal of Applied Physics (01-11-1990)“…Y-Ba-Cu-O bulk superconductor including small particles of BaSnO 3 was synthesized by the unidirectional melt solidification method. Finely dispersed Y 2 BaCuO…”
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Valence study of orthorhombic and tetragonal Ba2YCu3Oy: the role of oxygen vacancies in high-Tc superconductivity
Published in Japanese journal of applied physics (01-09-1987)Get full text
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Possibility of superconductivity at 65°C in Sr-Ba-Y-Cu-O system
Published in Japanese Journal of Applied Physics (01-08-1987)“…Transition to a zero-resistance state at 65°C (338 K) was observd in a Sr-Ba-Y-Cu-O system for the first time. A nonlinear I-V characteristic curve was…”
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Preparation of Y-Ba-Cu-O superconductors with high critical current density by unidirectional melt solidification
Published in Japanese Journal of Applied Physics (01-02-1990)“…Y-Ba-Cu-O superconductors with high J c have been prepared by a unidirectional melt solidification method. Uniformly oriented plate-shaped YBa 2 Cu 3 O 7- y…”
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20
cGMP-dependent phosphorylation and degradation of myristoylated alanine-rich C-kinase substrate
Published in Biochemical and biophysical research communications (28-01-2005)“…In the mammalian brain, nitric oxide (NO) has been implicated in neuronal signal transmissions. NO stimulates guanylate cyclase to increase intracellular cGMP,…”
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