Search Results - "Matsubara, Mayumi"

Homologous Recombination but Not Nucleotide Excision Repair Plays a Pivotal Role in Tolerance of DNA-Protein Cross-links in Mammalian Cells by Nakano, Toshiaki, Katafuchi, Atsushi, Matsubara, Mayumi, Terato, Hiroaki, Tsuboi, Tomohiro, Masuda, Tasuku, Tatsumoto, Takahiro, Pack, Seung Pil, Makino, Keisuke, Croteau, Deborah L., Van Houten, Bennett, Iijima, Kenta, Tauchi, Hiroshi, Ide, Hiroshi

“…DNA-protein cross-links (DPCs) are unique among DNA lesions in their unusually bulky nature. The steric hindrance imposed by cross-linked proteins (CLPs) will…”
Get full text

Functional interaction of regulator of G protein signaling-2 with melanin-concentrating hormone receptor 1 by Miyamoto-Matsubara, Mayumi, Chung, Shinjae, Saito, Yumiko

“…Melanin‐concentrating hormone receptor 1 (MCHR1) is a G protein–coupled receptor (GPCR) highly expressed in the central nervous system. MCHR1 mediates many…”
Get full text

Translocation and Stability of Replicative DNA Helicases upon Encountering DNA-Protein Cross-links by Nakano, Toshiaki, Miyamoto-Matsubara, Mayumi, Shoulkamy, Mahmoud I., Salem, Amir M.H., Pack, Seung Pil, Ishimi, Yukio, Ide, Hiroshi

“…DNA-protein cross-links (DPCs) are formed when cells are exposed to various DNA-damaging agents. Because DPCs are extremely large, steric hindrance conferred…”
Get full text

Mammalian 5-Formyluracil−DNA Glycosylase. 2. Role of SMUG1 Uracil−DNA Glycosylase in Repair of 5-Formyluracil and Other Oxidized and Deaminated Base Lesions by Masaoka, Aya, Matsubara, Mayumi, Hasegawa, Rei, Tanaka, Tamon, Kurisu, Satofumi, Terato, Hiroaki, Ohyama, Yoshihiko, Karino, Naoko, Matsuda, Akira, Ide, Hiroshi

“…In the accompanying paper [Matsubara, M., et al. (2003) Biochemistry 42, 4993−5002], we have partially purified and characterized rat 5-formyluracil (fU)−DNA…”
Get full text

Roles of base excision repair enzymes Nth1p and Apn2p from Schizosaccharomyces pombe in processing alkylation and oxidative DNA damage by Sugimoto, Takanori, Igawa, Emi, Tanihigashi, Haruna, Matsubara, Mayumi, Ide, Hiroshi, Ikeda, Shogo

“…Schizosaccharomyces pombe Nthpl, an ortholog of the endonuclease III family, is the sole bifunctional DNA glycosylase encoded in its genome. The enzyme removes…”
Get full text

Action mechanism of human SMUG1 uracil-DNA glycosylase by Matsubara, Mayumi, Tanaka, Tamon, Terato, Hiroaki, Ide, Hiroshi

“…The DNA lesions resulting from deamination or oxidation of bases are generally repaired by the base excision repair pathway initiated by damage-specific DNA…”
Get full text

Repair and biochemical effects of DNA-protein crosslinks by Ide, Hiroshi, Shoulkamy, Mahmoud I, Nakano, Toshiaki, Miyamoto-Matsubara, Mayumi, Salem, Amir M H

“…Genomic DNA is associated with various structural, regulatory, and transaction proteins. The dynamic and reversible association between proteins and DNA…”
Get more information

Nucleotide Excision Repair and Homologous Recombination Systems Commit Differentially to the Repair of DNA-Protein Crosslinks by Nakano, Toshiaki, Morishita, Soh, Katafuchi, Atsushi, Matsubara, Mayumi, Horikawa, Yusuke, Terato, Hiroaki, Salem, Amir M.H., Izumi, Shunsuke, Pack, Seung Pil, Makino, Keisuke, Ide, Hiroshi

“…DNA-protein crosslinks (DPCs)—where proteins are covalently trapped on the DNA strand—block the progression of replication and transcription machineries and…”
Get full text

Regulation of melanin-concentrating hormone receptor 1 signaling by RGS8 with the receptor third intracellular loop by Miyamoto-Matsubara, Mayumi, Saitoh, Osamu, Maruyama, Kei, Aizaki, Yoshimi, Saito, Yumiko

“…Melanin-concentrating hormone (MCH) receptor 1 (MCH1R) belongs to the class A G protein-coupled receptors (GPCRs). The MCH–MCH1R system plays a central role in…”
Get full text

Mutational analysis of the damage-recognition and catalytic mechanism of human SMUG1 DNA glycosylase by Matsubara, Mayumi, Tanaka, Tamon, Terato, Hiroaki, Ohmae, Eiji, Izumi, Shunsuke, Katayanagi, Katsuo, Ide, Hiroshi

“…Single-strand selective monofunctional uracil-DNA glycosylase (SMUG1), previously thought to be a backup enzyme for uracil-DNA glycosylase, has recently been…”
Get full text

New utopia by Matsubara, Mayumi

“…When I observed Japan from a distance for the first time, I found a similarity between Japanese society and the idea of 'Utopia, 1 and I became interested in…”
Get full text

Mammalian 5-Formyluracil−DNA Glycosylase. 1. Identification and Characterization of a Novel Activity That Releases 5-Formyluracil from DNA by Matsubara, Mayumi, Masaoka, Aya, Tanaka, Tamon, Miyano, Takayuki, Kato, Nagisa, Terato, Hiroaki, Ohyama, Yoshihiko, Iwai, Shigenori, Ide, Hiroshi

“…5-Formyluracil (fU) is a major oxidative thymine lesion produced by reactive oxygen species and exhibits genotoxic and cytotoxic effects via several…”
Get full text

Action mechanism of human SMUG1 uracil-DNA glycosylase by Matsubara, Mayumi, Tanaka, Tamon, Terato, Hiroaki, Ide, Hiroshi

“…The DNA lesions resulting from deamination or oxidation of bases are generally repaired by the base excision repair pathway initiated by damage-specific DNA…”
Get full text

Damage specificity of human DNA glycosylases for oxidative pyrimidine lesions by Katafuchi, Atsushi, Matsubara, Mayumi, Terato, Hiroaki, Iwai, Shigenori, Hanaoka, Fumio, Ide, Hiroshi

“…Endo III and Endo VIII are major E. coli DNA glycosylases that remove oxidatively damaged pyrimidine bases. In the present study, we have compared the damage…”
Get full text

Identification and characterization of mammalian 5-formyluracil-DNA glycosylase by Matsubara, Mayumi, Masaoka, Aya, Tanaka, Tamon, Terato, Hiroaki, Ohyama, Yoshihiko, Ide, Hiroshi

“…5-Formyluracil is a major oxidative thymine lesion with mutagenic and cytotoxic properties. In this study, we have partially purified and characterized a…”
Get full text

Repair roles of hSMUG1 assessed by damage specificity and cellular activity by Masaoka, Aya, Matsubara, Mayumi, Tanaka, Tamon, Terato, Hiroaki, Ohyama, Yoshihiko, Kubo, Kihei, Ide, Hiroshi

“…Single-strand-selective monofunctional uracil-DNA glycosylase (SMUG1) was previously identified as a putative backup enzyme of major mammalian uracil-DNA…”
Get full text

Repair roles of hSMUG1 assessed by damage specificity and cellular activity by Masaoka, Aya, Matsubara, Mayumi, Tanaka, Tamon, Terato, Hiroaki, Ohyama, Yoshihiko, Kubo, Kihei, Ide, Hiroshi

“…Single-strand-selective monofunctional uracil-DNA glycosylase (SMUG1) was previously identified as a putative backup enzyme of major mammalian uracil-DNA…”
Get more information

Identification and characterization of mammalian 5-formyluracil-DNA glycosylase by Matsubara, Mayumi, Masaoka, Aya, Tanaka, Tamon, Terato, Hiroaki, Ohyama, Yoshihiko, Ide, Hiroshi

“…5-Formyluracil is a major oxidative thymine lesion with mutagenic and cytotoxic properties. In this study, we have partially purified and characterized a…”
Get more information