Search Results - "Matrone, Nunzia"

EPHA2 Is a Predictive Biomarker of Resistance and a Potential Therapeutic Target for Improving Antiepidermal Growth Factor Receptor Therapy in Colorectal Cancer by Martini, Giulia, Cardone, Claudia, Vitiello, Pietro Paolo, Belli, Valentina, Napolitano, Stefania, Troiani, Teresa, Ciardiello, Davide, Della Corte, Carminia Maria, Morgillo, Floriana, Matrone, Nunzia, Sforza, Vincenzo, Papaccio, Gianpaolo, Desiderio, Vincenzo, Paul, Mariel C, Moreno-Viedma, Veronica, Normanno, Nicola, Rachiglio, Anna Maria, Tirino, Virginia, Maiello, Evaristo, Latiano, Tiziana Pia, Rizzi, Daniele, Signoriello, Giuseppe, Sibilia, Maria, Ciardiello, Fortunato, Martinelli, Erika

“…The EPHA2 tyrosine kinase receptor is implicated in tumor progression and targeted therapies resistance. We evaluated EPHA2 as a potential resistance marker to…”
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Receptor tyrosine kinase-dependent PI3K activation is an escape mechanism to vertical suppression of the EGFR/RAS/MAPK pathway in KRAS-mutated human colorectal cancer cell lines by Vitiello, Pietro Paolo, Cardone, Claudia, Martini, Giulia, Ciardiello, Davide, Belli, Valentina, Matrone, Nunzia, Barra, Giusi, Napolitano, Stefania, Della Corte, Carmina, Turano, Mimmo, Furia, Maria, Troiani, Teresa, Morgillo, Floriana, De Vita, Ferdinando, Ciardiello, Fortunato, Martinelli, Erika

“…Previous studies showed that the combination of an anti-Epidermal growth factor (EGFR) and a MEK-inhibitor is able to prevent the onset of resistance to…”
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Vulnerability to low-dose combination of irinotecan and niraparib in ATM-mutated colorectal cancer by Vitiello, Pietro Paolo, Martini, Giulia, Mele, Luigi, Giunta, Emilio Francesco, De Falco, Vincenzo, Ciardiello, Davide, Belli, Valentina, Cardone, Claudia, Matrone, Nunzia, Poliero, Luca, Tirino, Virginia, Napolitano, Stefania, Della Corte, Carminia, Selvaggi, Francesco, Papaccio, Gianpaolo, Troiani, Teresa, Morgillo, Floriana, Desiderio, Vincenzo, Ciardiello, Fortunato, Martinelli, Erika

“…Despite the advancements in new therapies for colorectal cancer (CRC), chemotherapy still constitutes the mainstay of the medical treatment. For this reason,…”
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Combined blockade of MEK and PI3KCA as an effective antitumor strategy in HER2 gene amplified human colorectal cancer models by Belli, Valentina, Matrone, Nunzia, Napolitano, Stefania, Migliardi, Giorgia, Cottino, Francesca, Bertotti, Andrea, Trusolino, Livio, Martinelli, Erika, Morgillo, Floriana, Ciardiello, Davide, De Falco, Vincenzo, Giunta, Emilio Francesco, Bracale, Umberto, Ciardiello, Fortunato, Troiani, Teresa

“…Targeting the epidermal growth factor receptor (EGFR) either alone or in combination with chemotherapy is an effective treatment for patients with RAS…”
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Dual inhibition of TGFβ and AXL as a novel therapy for human colorectal adenocarcinoma with mesenchymal phenotype by Ciardiello, Davide, Blauensteiner, Bernadette, Matrone, Nunzia, Belli, Valentina, Mohr, Thomas, Vitiello, Pietro Paolo, Martini, Giulia, Poliero, Luca, Cardone, Claudia, Napolitano, Stefania, De Falco, Vincenzo, Giunta, Emilio Francesco, Ciaramella, Vincenza, Corte, Carminia della, Barra, Giusi, Selvaggi, Francesco, Franco, Renato, Marino, Federica Zito, Cuomo, Antonio, Morgillo, Floriana, Troiani, Teresa, Sibilia, Maria, Ciardiello, Fortunato, Martinelli, Erika

“…A subset of colorectal cancer (CRC) with a mesenchymal phenotype (CMS4) displays an aggressive disease, with an increased risk of recurrence after surgery,…”
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A functional connection between dyskerin and energy metabolism by Angrisani, Alberto, Matrone, Nunzia, Belli, Valentina, Vicidomini, Rosario, Di Maio, Nunzia, Turano, Mimmo, Scialò, Filippo, Netti, Paolo Antonio, Porcellini, Antonio, Furia, Maria

“…The human DKC1 gene encodes dyskerin, an evolutionarily conserved nuclear protein whose overexpression represents a common trait of many types of aggressive…”
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A dynamic link between H/ACA snoRNP components and cytoplasmic stress granules by Belli, Valentina, Matrone, Nunzia, Sagliocchi, Serena, Incarnato, Rosa, Conte, Andrea, Pizzo, Elio, Turano, Mimmo, Angrisani, Alberto, Furia, Maria

“…Many cell stressors block protein translation, inducing formation of cytoplasmic aggregates. These aggregates, named stress granules (SGs), are composed by…”
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AXL is a predictor of poor survival and of resistance to anti-EGFR therapy in RAS wild-type metastatic colorectal cancer by Cardone, Claudia, Blauensteiner, Bernadette, Moreno-Viedma, Veronica, Martini, Giulia, Simeon, Vittorio, Vitiello, Pietro P., Ciardiello, Davide, Belli, Valentina, Matrone, Nunzia, Troiani, Teresa, Morgillo, Floriana, Zito Marino, Federica, Dentice, Monica, Nappi, Annarita, Boccaccino, Alessandra, Antoniotti, Carlotta, Cremolini, Chiara, Pietrantonio, Filippo, Prager, Gerald W., Normanno, Nicola, Maiello, Evaristo, Argiles, Guillem, Elez, Elena, Signoriello, Giuseppe, Franco, Renato, Falcone, Alfredo, Tabernero, Josep, Sibilia, Maria, Ciardiello, Fortunato, Martinelli, Erika

“…RAS mutations are the only validated biomarkers in metastatic colorectal cancer (mCRC) for anti-epidermal growth factor receptor (EGFR) therapy. Limited…”
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Abstract 4904: PD-L1 pathway activation as an escape mechanism of resistance to MEK inhibitor treatment in human colorectal cancer models by Napolitano, Stefania, Matrone, Nunzia, Belli, Valentina, Falco, Vincenzo De, Martinelli, Erika, Kopetz, Scott, Ciardiello, Fortunato, Troiani, Teresa

“…Abstract Molecular mechanisms driving acquired resistance to anti-EGFR therapies in mCRC is complex and biochemically converge to activate the EGFR-RAS-MAPK…”
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Abstract 2841: Her2/neu expression as potential marker of regorafenib resistance in CRC by Vecchione, Loredana, Napolitano, Stefania, Belli, Valentina, Martinelli, Erika, Matrone, Nunzia, Hapke, Christophe, Keilholz, Ulrich, Tabernero, Josep, Ciardiello, Fortunato, Troiani, Teresa

“…Abstract Nature Reviews Clinical Oncology, (2017). doi:10.1038/nrclinonc.2017.43 Jason J. Luke 0 0 2017-03-27T13:39:00Z 2017-11-29T14:35:00Z 1 312 1781 14 4…”
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Regorafenib in combination with silybin as a novel potential strategy for the treatment of metastatic colorectal cancer by Belli, Valentina, Sforza, Vincenzo, Cardone, Claudia, Martinelli, Erika, Barra, Giusi, Matrone, Nunzia, Napolitano, Stefania, Morgillo, Floriana, Tuccillo, Concetta, Federico, Alessandro, Dallio, Marcello, Loguercio, Carmelina, Gravina, Antonietta Gerarda, De Palma, Raffaele, Ciardiello, Fortunato, Troiani, Teresa

“…Regorafenib, an oral multikinase inhibitor, has demonstrated survival benefit in metastatic colorectal cancer (mCRC) patients that have progressed after all…”
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Abstract 295: Synergism between oxaliplatin or irinotecan with the PARP inhibitor niraparib in a preclinical model of KRAS/BRAF mutated colorectal cancer is associated with MSI status by Vitiello, Pietro Paolo, Ciardiello, Davide, Cardone, Claudia, Martini, Giulia, Belli, Valentina, Matrone, Nunzia, Poliero, Luca, Borrelli, Carola, Vitale, Pasquale, Zanaletti, Nicoletta, Troiani, Teresa, Melisi, Davide, Ciardiello, Fortunato, Martinelli, Erika

“…Abstract DNA damage response (DDR) is crucial in a variety of tumors and several new drugs that interfere with this mechanism are already available or in…”
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Abstract 2627: Inhibition of TGFβ in colorectal cancer cells is associated with a compensatory activation of AXL and p38 MAPK signaling pathways by Ciardiello, Davide, Vitiello, Pietro Paolo, Matrone, Nunzia, Belli, Valentina, Cardone, Claudia, Poliero, Luca, Borrelli, Carola, Arrichiello, Gianluca, Martini, Giulia, Ciaramella, Vincenza, Barra, Giusi, Morgillo, Floriana, Troiani, Teresa, Melisi, Davide, Ciardiello, Fortunato, Martinelli, Erika

“…Abstract According to the consensus molecular subtypes (CMS), almost 23% of human colorectal cancer (CRC) are classified in the CMS4 group, characterized by a…”
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Macrophage Migration Inhibitory Factor Is a Molecular Determinant of the Anti-EGFR Monoclonal Antibody Cetuximab Resistance in Human Colorectal Cancer Cells by Russo, Rosita, Matrone, Nunzia, Belli, Valentina, Ciardiello, Davide, Valletta, Mariangela, Esposito, Sabrina, Pedone, Paolo Vincenzo, Ciardiello, Fortunato, Troiani, Teresa, Chambery, Angela

“…Background: The clinical impact of the monoclonal antibody cetuximab targeting the EGFR in colorectal cancer (CRC) is widely recognized. Nevertheless, the…”
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Antitumor efficacy of triple monoclonal antibody inhibition of epidermal growth factor receptor (EGFR) with MM151 in EGFR-dependent and in cetuximab-resistant human colorectal cancer cells by Napolitano, Stefania, Martini, Giulia, Martinelli, Erika, Della Corte, Carminia Maria, Morgillo, Floriana, Belli, Valentina, Cardone, Claudia, Matrone, Nunzia, Ciardiello, Fortunato, Troiani, Teresa

“…We investigated the effect of triple monoclonal antibody inhibition of EGFR to overcome acquired resistance to first generation of anti-EGFR inhibitors. MM151…”
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