Search Results - "Matreyek, Kenneth A."

The Requirement for Nucleoporin NUP153 during Human Immunodeficiency Virus Type 1 Infection Is Determined by the Viral Capsid by MATREYEK, Kenneth A, ENGELMAN, Alan

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Expanded ACE2 dependencies of diverse SARS-like coronavirus receptor binding domains by Roelle, Sarah M, Shukla, Nidhi, Pham, Anh T, Bruchez, Anna M, Matreyek, Kenneth A

“…Viral spillover from animal reservoirs can trigger public health crises and cripple the world economy. Knowing which viruses are primed for zoonotic…”
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Nucleoporin NUP153 phenylalanine-glycine motifs engage a common binding pocket within the HIV-1 capsid protein to mediate lentiviral infectivity by Matreyek, Kenneth A, Yücel, Sara S, Li, Xiang, Engelman, Alan

“…Lentiviruses can infect non-dividing cells, and various cellular transport proteins provide crucial functions for lentiviral nuclear entry and integration. We…”
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On the design of CRISPR-based single-cell molecular screens by Hill, Andrew J, McFaline-Figueroa, José L, Starita, Lea M, Gasperini, Molly J, Matreyek, Kenneth A, Packer, Jonathan, Jackson, Dana, Shendure, Jay, Trapnell, Cole

“…CRISPR-based single-cell pooled screens that use linked barcodes suffer from lost sensitivity due to lentiviral template switching. The barcode-free CROP-seq…”
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Mutants of human ACE2 differentially promote SARS-CoV and SARS-CoV-2 spike mediated infection by Shukla, Nidhi, Roelle, Sarah M, Suzart, Vinicius G, Bruchez, Anna M, Matreyek, Kenneth A

“…SARS-CoV and SARS-CoV-2 encode spike proteins that bind human ACE2 on the cell surface to enter target cells during infection. A small fraction of humans…”
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MHC class II transactivator CIITA induces cell resistance to Ebola virus and SARS-like coronaviruses by Bruchez, Anna, Sha, Ky, Johnson, Joshua, Chen, Li, Stefani, Caroline, McConnell, Hannah, Gaucherand, Lea, Prins, Rachel, Matreyek, Kenneth A, Hume, Adam J, Mühlberger, Elke, Schmidt, Emmett V, Olinger, Gene G, Stuart, Lynda M, Lacy-Hulbert, Adam

“…Recent outbreaks of Ebola virus (EBOV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have exposed our limited therapeutic options for such…”
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Viral and cellular requirements for the nuclear entry of retroviral preintegration nucleoprotein complexes by Matreyek, Kenneth A, Engelman, Alan

“…Retroviruses integrate their reverse transcribed genomes into host cell chromosomes as an obligate step in virus replication. The nuclear envelope separates…”
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Probing ion channel functional architecture and domain recombination compatibility by massively parallel domain insertion profiling by Coyote-Maestas, Willow, Nedrud, David, Suma, Antonio, He, Yungui, Matreyek, Kenneth A., Fowler, Douglas M., Carnevale, Vincenzo, Myers, Chad L., Schmidt, Daniel

“…Protein domains are the basic units of protein structure and function. Comparative analysis of genomes and proteomes showed that domain recombination is a main…”
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Structural Insight into HIV-1 Restriction by MxB by Fribourgh, Jennifer L., Nguyen, Henry C., Matreyek, Kenneth A., Alvarez, Frances Joan D., Summers, Brady J., Dewdney, Tamaria G., Aiken, Christopher, Zhang, Peijun, Engelman, Alan, Xiong, Yong

“…The myxovirus resistance (Mx) proteins are interferon-induced dynamin GTPases that can inhibit a variety of viruses. Recently, MxB, but not MxA, was shown to…”
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High-throughput identification of prefusion-stabilizing mutations in SARS-CoV-2 spike by Tan, Timothy J. C., Mou, Zongjun, Lei, Ruipeng, Ouyang, Wenhao O., Yuan, Meng, Song, Ge, Andrabi, Raiees, Wilson, Ian A., Kieffer, Collin, Dai, Xinghong, Matreyek, Kenneth A., Wu, Nicholas C.

“…Designing prefusion-stabilized SARS-CoV-2 spike is critical for the effectiveness of COVID-19 vaccines. All COVID-19 vaccines in the US encode spike with…”
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Pseudotyped virus infection of multiplexed ACE2 libraries reveals SARS-CoV-2 variant shifts in receptor usage by Shukla, Nidhi, Roelle, Sarah M, Snell, John C, DelSignore, Olivia, Bruchez, Anna M, Matreyek, Kenneth A

“…Pairwise compatibility between virus and host proteins can dictate the outcome of infection. During transmission, both inter- and intraspecies variabilities in…”
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High-throughput discovery of trafficking-deficient variants in the cardiac potassium channel KV11.1 by Kozek, Krystian A., Glazer, Andrew M., Ng, Chai-Ann, Blackwell, Daniel, Egly, Christian L., Vanags, Loren R., Blair, Marcia, Mitchell, Devyn, Matreyek, Kenneth A., Fowler, Douglas M., Knollmann, Bjorn C., Vandenberg, Jamie I., Roden, Dan M., Kroncke, Brett M.

“…KCHN2 encodes the KV11.1 potassium channel responsible for IKr, a major repolarization current during the cardiomyocyte action potential. Variants in KCNH2…”
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Multiplexed measurement of variant abundance and activity reveals VKOR topology, active site and human variant impact by Chiasson, Melissa A, Rollins, Nathan J, Stephany, Jason J, Sitko, Katherine A, Matreyek, Kenneth A, Verby, Marta, Sun, Song, Roth, Frederick P, DeSloover, Daniel, Marks, Debora S, Rettie, Allan E, Fowler, Douglas M

“…Vitamin K epoxide reductase (VKOR) drives the vitamin K cycle, activating vitamin K-dependent blood clotting factors. VKOR is also the target of the widely…”
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Differential Effects of Human Immunodeficiency Virus Type 1 Capsid and Cellular Factors Nucleoporin 153 and LEDGF/p75 on the Efficiency and Specificity of Viral DNA Integration by Koh, Yasuhiro, Wu, Xiaolin, Ferris, Andrea L, Matreyek, Kenneth A, Smith, Steven J, Lee, KyeongEun, KewalRamani, Vineet N, Hughes, Stephen H, Engelman, Alan

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Integrating thousands of PTEN variant activity and abundance measurements reveals variant subgroups and new dominant negatives in cancers by Matreyek, Kenneth A, Stephany, Jason J, Ahler, Ethan, Fowler, Douglas M

“…PTEN is a multi-functional tumor suppressor protein regulating cell growth, immune signaling, neuronal function, and genome stability. Experimental…”
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The Requirement for Cellular Transportin 3 (TNPO3 or TRN-SR2) during Infection Maps to Human Immunodeficiency Virus Type 1 Capsid and Not Integrase by KRISHNAN, Lavanya, MATREYEK, Kenneth A, OZTOP, Ilker, LEE, Kyeongeun, TIPPER, Christopher H, XIANG LI, DAR, Mohd J, KEWALRAMANI, Vineet N, ENGELMAN, Alan

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Host and viral determinants for MxB restriction of HIV-1 infection by Matreyek, Kenneth A, Wang, Weifeng, Serrao, Erik, Singh, Parmit Kumar, Levin, Henry L, Engelman, Alan

“…Interferon-induced cellular proteins play important roles in the host response against viral infection. The Mx family of dynamin-like GTPases, which include…”
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Receptor-Binding Domain (RBD) Antibodies Contribute More to SARS-CoV-2 Neutralization When Target Cells Express High Levels of ACE2 by Farrell, Ariana Ghez, Dadonaite, Bernadeta, Greaney, Allison J, Eguia, Rachel, Loes, Andrea N, Franko, Nicholas M, Logue, Jennifer, Carreño, Juan Manuel, Abbad, Anass, Chu, Helen Y, Matreyek, Kenneth A, Bloom, Jesse D

“…Neutralization assays are experimental surrogates for the effectiveness of infection- or vaccine-elicited polyclonal antibodies and therapeutic monoclonal…”
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High-throughput functional mapping of variants in an arrhythmia gene, KCNE1, reveals novel biology by Muhammad, Ayesha, Calandranis, Maria E, Li, Bian, Yang, Tao, Blackwell, Daniel J, Harvey, M Lorena, Smith, Jeremy E, Daniel, Zerubabell A, Chew, Ashli E, Capra, John A, Matreyek, Kenneth A, Fowler, Douglas M, Roden, Dan M, Glazer, Andrew M

“…KCNE1 encodes a 129-residue cardiac potassium channel (I ) subunit. KCNE1 variants are associated with long QT syndrome and atrial fibrillation. However, most…”
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Polybasic KKR Motif in the Cytoplasmic Tail of Nipah Virus Fusion Protein Modulates Membrane Fusion by Inside-Out Signaling by AGUILAR, Hector C, MATREYEK, Kenneth A, CHOI, Daniel Y, FILONE, Claire Marie, YOUNG, Sophia, LEE, Benhur

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