Search Results - "Matoyama, Masaaki"
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Synthesis and biological evaluation of loxoprofen derivatives
Published in Bioorganic & medicinal chemistry (01-06-2011)“…Non-steroidal anti-inflammatory drugs (NSAIDs) achieve their anti-inflammatory actions through an inhibitory effect on cyclooxygenase (COX). Two COX subtypes,…”
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Properties and Synthesis of 2-{2-Fluoro (or Bromo)-4-[(2-oxocyclopentyl)methyl]phenyl}propanoic Acid: Nonsteroidal Anti-inflammatory Drugs with Low Membrane Permeabilizing and Gastric Lesion-Producing Activities
Published in Journal of medicinal chemistry (11-11-2010)“…We previously proposed that membrane permeabilization activity of NSAIDs is involved in NSAID-induced gastric lesions. We here synthesized derivatives of…”
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Journal Article