Search Results - "Matos, Maria João"

Chromone: A Valid Scaffold in Medicinal Chemistry by Gaspar, Alexandra, Matos, Maria João, Garrido, Jorge, Uriarte, Eugenio, Borges, Fernanda

“…Gaspar et al examine chromone with regard to medicinal chemistry…”
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Trending Topics on Coumarin and Its Derivatives in 2020 by Carneiro, Aitor, Matos, Maria João, Uriarte, Eugenio, Santana, Lourdes

“…Coumarins are naturally occurring molecules with a versatile range of activities. Their structural and physicochemical characteristics make them a privileged…”
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Coumarin and Its Derivatives—Editorial by Matos, Maria João

“…Coumarins are widely distributed in nature and can be found in a large number of naturally occurring and synthetic bioactive molecules [...]…”
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Novel 2-pheynlbenzofuran derivatives as selective butyrylcholinesterase inhibitors for Alzheimer’s disease by Kumar, Amit, Pintus, Francesca, Di Petrillo, Amalia, Medda, Rosaria, Caria, Paola, Matos, Maria João, Viña, Dolores, Pieroni, Enrico, Delogu, Francesco, Era, Benedetta, Delogu, Giovanna L., Fais, Antonella

“…Alzheimer’s disease (AD) is a neurodegenerative disorder representing the leading cause of dementia and is affecting nearly 44 million people worldwide. AD is…”
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Antibacterial Activity and Molecular Docking Studies of a Selected Series of Hydroxy-3-arylcoumarins by Pisano, Maria Barbara, Kumar, Amit, Medda, Rosaria, Gatto, Gianluca, Pal, Rajesh, Fais, Antonella, Era, Benedetta, Cosentino, Sofia, Uriarte, Eugenio, Santana, Lourdes, Pintus, Francesca, Matos, Maria João

“…Antibiotic resistance is one of the main public health concerns of this century. This resistance is also associated with oxidative stress, which could…”
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Evaluation of in vitro cytotoxic and genotoxic effects of the 3-(3,4-dihydroxyphenyl)-8-hydroxycoumarin by Dos Santos Silva, Edvannia, Matos, Maria João, Maistro, Edson Luis

“…A wide variety of natural and synthetic coumarins present therapeutic potential. Therefore, the assessment of their safety for humans is essential…”
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PEGylated PLGA Nanoparticles As a Smart Carrier to Increase the Cellular Uptake of a Coumarin-Based Monoamine Oxidase B Inhibitor by Fernandes, Carlos, Martins, Cláudia, Fonseca, André, Nunes, Rute, Matos, Maria João, Silva, Renata, Garrido, Jorge, Sarmento, Bruno, Remião, Fernando, Otero-Espinar, Francisco J, Uriarte, Eugenio, Borges, Fernanda

“…Despite research efforts to discover new drugs for Parkinson treatment, the majority of candidates fail in preclinical and clinical trials due to inadequate…”
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Coumarin versus Chromone Monoamine Oxidase B Inhibitors: Quo Vadis? by Fonseca, André, Reis, Joana, Silva, Tiago, Matos, Maria João, Bagetta, Donatella, Ortuso, Francesco, Alcaro, Stefano, Uriarte, Eugenio, Borges, Fernanda

“…Because of the lack of significant disease-modifying drugs for neurodegenerative disorders, a pressing need for new chemical entities endowed with IMAO-B still…”
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Recent Advances in Biologically Active Coumarins from Marine Sources: Synthesis and Evaluation by Fernández-Peña, Laura, Matos, Maria João, López, Enol

“…Coumarin and its derivatives have significantly attracted the attention of medicinal chemists and chemical biologists due to their huge range of biological,…”
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Synthesis and Electrochemical and Biological Studies of Novel Coumarin–Chalcone Hybrid Compounds by Pérez-Cruz, Fernanda, Vazquez-Rodriguez, Saleta, Matos, Maria João, Herrera-Morales, Alejandra, Villamena, Frederick A, Das, Amlan, Gopalakrishnan, Bhavani, Olea-Azar, Claudio, Santana, Lourdes, Uriarte, Eugenio

“…A series of novel hydroxy-coumarin–chalcone hybrid compounds 2a–i has been synthesized by employing a simple and efficient methodology. An electrochemical…”
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Hydroxy-3-Phenylcoumarins as Multitarget Compounds for Skin Aging Diseases: Synthesis, Molecular Docking and Tyrosinase, Elastase, Collagenase and Hyaluronidase Inhibition, and Sun Protection Factor by Pintus, Francesca, Floris, Sonia, Fais, Antonella, Era, Benedetta, Kumar, Amit, Gatto, Gianluca, Uriarte, Eugenio, Matos, Maria João

“…Skin aging is a progressive biological process of the human body, and it is not only time-dependent. Differently substituted 3-phenylcoumarins proved to…”
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Study of the DNA damage and cell death in human peripheral blood mononuclear and HepG2/C3A cells exposed to the synthetic 3-(3-hydroxyphenyl)-7-hydroxycoumarin by Pereira, André Rogerio, Campos, Ashley Silva, Matos, Maria João, Maistro, Edson Luis

“…Hydroxycoumarins are an important source of biologically active compounds. Previous studies have shown that the number and position of the hydroxyl…”
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A New Class of Benzo[ b ]thiophene-chalcones as Cholinesterase Inhibitors: Synthesis, Biological Evaluation, Molecular Docking and ADME Studies by Delogu, Giovanna Lucia, Begala, Michela, Matos, Maria João, Crucitti, Davide, Sogos, Valeria, Era, Benedetta, Fais, Antonella

“…In this study, heterocyclic compounds containing a benzothiophene scaffold were designed and synthetized, and their inhibitory activity against cholinesterases…”
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Design of 3-Phenylcoumarins and 3-Thienylcoumarins as Potent Xanthine Oxidase Inhibitors: Synthesis, Biological Evaluation, and Docking Studies by Fais, Antonella, Pintus, Francesca, Era, Benedetta, Floris, Sonia, Kumar, Amit, Sarmadhikari, Debapriyo, Sogos, Valeria, Uriarte, Eugenio, Asthana, Shailendra, Matos, Maria João

“…Coumarin scaffold has proven to be promising in the development of bioactive agents, such as xanthine oxidase (XO) inhibitors. Novel hydroxylated…”
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Focusing on new monoamine oxidase inhibitors: differently substituted coumarins as an interesting scaffold by Matos, Maria João, Viña, Dolores, Vazquez-Rodriguez, Saleta, Uriarte, Eugenio, Santana, Lourdes

“…It is commonly accepted that monoamine oxidase (MAO) may play a critical role in the regulation of the central nervous system activity and contribute to the…”
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Medicinal Chemistry in Portugal and Spain: A Strong Iberian Alliance  Call for Papers by Matos, Maria João, Blanco, Maria-Jesus

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Unexpected one-step synthesis of 3-benzoyl-2-phenylbenzofurans under Wittig conditions by Begala, Michela, Caboni, Pierluigi, Matos, Maria João, Delogu, Giovanna Lucia

“…[Display omitted] •The Wittig reaction affords 3-benzoyl-2-phenylbenzofurans from triphenylphosphonium salt and aroyl chlorides.•A variety of new deactivated…”
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Adenosine Receptor Ligands: Coumarin–Chalcone Hybrids as Modulating Agents on the Activity of hARs by Vazquez-Rodriguez, Saleta, Vilar, Santiago, Kachler, Sonja, Klotz, Karl-Norbert, Uriarte, Eugenio, Borges, Fernanda, Matos, Maria João

“…Adenosine receptors (ARs) play an important role in neurological and psychiatric disorders such as Alzheimer’s disease, Parkinson’s disease, epilepsy and…”
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Synthesis and Vasorelaxant Activity of Nitrate−Coumarin Derivatives by Matos, Maria João, Uriarte, Eugenio, Seoane, Nuria, Picos, Aitor, Gil‐Longo, José, Campos‐Toimil, Manuel

“…Due to the need for new chemical entities for cardiovascular diseases, we have synthesized a new series of nitrate−coumarins and evaluated their vasorelaxant…”
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MAO inhibitory activity modulation: 3-Phenylcoumarins versus 3-benzoylcoumarins by Matos, Maria João, Vazquez-Rodriguez, Saleta, Uriarte, Eugenio, Santana, Lourdes, Viña, Dolores

“…With the aim of finding the structural features for the human MAO inhibitory activity and selectivity, in the present communication we report the synthesis,…”
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