Antineoplastic activity of selected constituents of Duguetia glabriuscula

Antineoplastic activity of selected constituents of Duguetia glabriuscula

The cytotoxic effects of seven constituents isolated from Duguetia glabriuscula were evaluated against Hep 2 human larynx carcinoma cells. The cytotoxicity exhibited by β-sitosterol was as strong as that of cis-platin. (+)-Alloaromadendran-10,14β-diol caused inhibition of cellular growth with IC 50...

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Bibliographic Details
Published in:Fitoterapia Vol. 77; no. 3; pp. 227 - 229
Main Authors: Matos, M.F.C., Leite, L.I.S.P., Brustolim, D., de Siqueira, J.M., Carollo, C.A., Hellmann, A.R., Pereira, N.F.G., da Silva, D.B.
Format: Journal Article
Language:English
Published: Amsterdam Elsevier B.V 01-04-2006
Elsevier
Subjects:
Annonaceae - chemistry
Antineoplastic Agents, Phytogenic - toxicity
Biological and medical sciences
Cell Line, Tumor
Cisplatin - toxicity
Cytotoxicity
Duguetia glabriuscula
General pharmacology
Humans
Inhibitory Concentration 50
Medical sciences
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Bark - chemistry
Plant Extracts - chemistry
Plant Extracts - toxicity
Plant Leaves - chemistry
Polycarpol
Polycyclic Aromatic Hydrocarbons - toxicity
Sesquiterpenes
Sitosterols - toxicity
Toxicity Tests - methods
β-Sitosterol
Cytotoxicity
Polycarpol
β-Sitosterol
Duguetia glabriuscula
Sesquiterpenes
Antineoplastic agent
p-Sitosterol
Pharmacognosy
Plant origin
Medicinal plant
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Description
Summary:The cytotoxic effects of seven constituents isolated from Duguetia glabriuscula were evaluated against Hep 2 human larynx carcinoma cells. The cytotoxicity exhibited by β-sitosterol was as strong as that of cis-platin. (+)-Alloaromadendran-10,14β-diol caused inhibition of cellular growth with IC 50 values lower than 25 μg/ml, a feature that was considered as revealing significant activity. Polycarpol showed borderline cytotoxicity, whereas the other compounds were inactive.
ISSN:0367-326X
DOI:10.1016/j.fitote.2006.01.013