Search Results - "Mato, Jose M."

S-adenosylmethionine in liver health, injury, and cancer by Lu, Shelly C, Mato, José M

“…S-adenosylmethionine (AdoMet, also known as SAM and SAMe) is the principal biological methyl donor synthesized in all mammalian cells but most abundantly in…”
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Schwann cell autophagy, myelinophagy, initiates myelin clearance from injured nerves by Gomez-Sanchez, Jose A, Carty, Lucy, Iruarrizaga-Lejarreta, Marta, Palomo-Irigoyen, Marta, Varela-Rey, Marta, Griffith, Megan, Hantke, Janina, Macias-Camara, Nuria, Azkargorta, Mikel, Aurrekoetxea, Igor, De Juan, Virginia Gutiérrez, Jefferies, Harold B J, Aspichueta, Patricia, Elortza, Félix, Aransay, Ana M, Martínez-Chantar, María L, Baas, Frank, Mato, José M, Mirsky, Rhona, Woodhoo, Ashwin, Jessen, Kristján R

“…Although Schwann cell myelin breakdown is the universal outcome of a remarkably wide range of conditions that cause disease or injury to peripheral nerves, the…”
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Metabolomics and lipidomics in NAFLD: biomarkers and non-invasive diagnostic tests by Masoodi, Mojgan, Gastaldelli, Amalia, Hyötyläinen, Tuulia, Arretxe, Enara, Alonso, Cristina, Gaggini, Melania, Brosnan, Julia, Anstee, Quentin M., Millet, Oscar, Ortiz, Pablo, Mato, Jose M., Dufour, Jean-Francois, Orešič, Matej

“…Nonalcoholic fatty liver disease (NAFLD) is one of the most common liver diseases worldwide and is often associated with aspects of metabolic syndrome. Despite…”
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Metabolomic Identification of Subtypes of Nonalcoholic Steatohepatitis by Alonso, Cristina, Fernández-Ramos, David, Varela-Rey, Marta, Martínez-Arranz, Ibon, Navasa, Nicolás, Van Liempd, Sebastiaan M, Lavin, José L, Mayo, Rebeca, Ilisso, Concetta P, de Juan, Virginia G, Iruarrizaga-Lejarreta, Marta, delaCruz-Villar, Laura, Mincholé, Itziar, Robinson, Aaron, Crespo, Javier, Martín-Duce, Antonio, Romero-Gomez, Manuel, Sann, Holger, Platon, Julian, Van Eyk, Jennifer, Aspichueta, Patricia, Noureddin, Mazen, Falcón-Pérez, Juan M, Anguita, Juan, Aransay, Ana M, Martínez-Chantar, María Luz, Lu, Shelly C, Mato, José M

“…Background & Aims Nonalcoholic fatty liver disease (NAFLD) is a consequence of defects in diverse metabolic pathways that involve hepatic accumulation of…”
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Methionine adenosyltransferases in liver cancer by Murray, Ben, Barbier-Torres, Lucia, Fan, Wei, Mato, José M, Lu, Shelly C

“…Methionine adenosyltransferases (MATs) are essential enzymes for life as they produce S-adenosylmethionine (SAMe), the biological methyl donor required for a…”
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S-adenosylmethionine Levels Regulate the Schwann Cell DNA Methylome by Varela-Rey, Marta, Iruarrizaga-Lejarreta, Marta, Lozano, Juan José, Aransay, Ana María, Fernandez, Agustín F., Lavin, José Luis, Mósen-Ansorena, David, Berdasco, María, Turmaine, Marc, Luka, Zigmund, Wagner, Conrad, Lu, Shelly C., Esteller, Manel, Mirsky, Rhona, Jessen, Kristján R., Fraga, Mario F., Martínez-Chantar, María L., Mato, José M., Woodhoo, Ashwin

“…Axonal myelination is essential for rapid saltatory impulse conduction in the nervous system, and malformation or destruction of myelin sheaths leads to motor…”
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Targeting Hepatic Glutaminase 1 Ameliorates Non-alcoholic Steatohepatitis by Restoring Very-Low-Density Lipoprotein Triglyceride Assembly by Simon, Jorge, Nuñez-García, Maitane, Fernández-Tussy, Pablo, Barbier-Torres, Lucía, Fernández-Ramos, David, Gómez-Santos, Beatriz, Buqué, Xabier, Lopitz-Otsoa, Fernando, Goikoetxea-Usandizaga, Naroa, Serrano-Macia, Marina, Rodriguez-Agudo, Rubén, Bizkarguenaga, Maider, Zubiete-Franco, Imanol, Gutiérrez-de Juan, Virginia, Cabrera, Diana, Alonso, Cristina, Iruzubieta, Paula, Romero-Gomez, Manuel, van Liempd, Sebastiaan, Castro, Azucena, Nogueiras, Ruben, Varela-Rey, Marta, Falcón-Pérez, Juan Manuel, Villa, Erica, Crespo, Javier, Lu, Shelly C., Mato, Jose M., Aspichueta, Patricia, Delgado, Teresa C., Martínez-Chantar, María Luz

“…Non-alcoholic steatohepatitis (NASH) is characterized by the accumulation of hepatic fat in an inflammatory/fibrotic background. Herein, we show that the…”
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S-Adenosylmethionine in cell growth, apoptosis and liver cancer by Lu, Shelly C, Mato, José M

“…S‐Adenosylmethionine (SAMe), the principal biological methyl donor, is synthesized from methionine and ATP in a reaction catalyzed by methionine…”
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Assays for Methionine γ‑Lyase and S‑Adenosyl‑l‑homocysteine Hydrolase Based on Enzymatic Formation of CdS Quantum Dots in Situ by Saa, Laura, Mato, José M, Pavlov, Valeri

“…S-Adenosyl-l-homocysteine hydrolase (AHCY) hydrolyzes its substrate S-adenosyl-l-homocysteine (AdoHcy) to l-homocysteine (Hcy). Methionine γ-lyase (MGL)…”
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Serum identification of at-risk MASH: The metabolomics-advanced steatohepatitis fibrosis score (MASEF) by Noureddin, Mazen, Truong, Emily, Mayo, Rebeca, Martínez-Arranz, Ibon, Mincholé, Itziar, Banales, Jesus M, Arrese, Marco, Cusi, Kenneth, Arias-Loste, María Teresa, Bruha, Radan, Romero-Gómez, Manuel, Iruzubieta, Paula, Aller, Rocio, Ampuero, Javier, Calleja, José Luis, Ibañez-Samaniego, Luis, Aspichueta, Patricia, Martín-Duce, Antonio, Kushner, Tatyana, Ortiz, Pablo, Harrison, Stephen A, Anstee, Quentin M, Crespo, Javier, Mato, José M, Sanyal, Arun J

“…Early identification of those with NAFLD activity score ≥ 4 and significant fibrosis (≥F2) or at-risk metabolic dysfunction-associated steatohepatitis (MASH)…”
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Metabolomics as a powerful tool for diagnostic, pronostic and drug intervention analysis in COVID-19 by Bruzzone, Chiara, Conde, Ricardo, Embade, Nieves, Mato, José M, Millet, Oscar

“…COVID-19 currently represents one of the major health challenges worldwide. Albeit its infectious character, with onset affectation mainly at the respiratory…”
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Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes by Conde-Vancells, Javier, Rodriguez-Suarez, Eva, Embade, Nieves, Gil, David, Matthiesen, Rune, Valle, Mikel, Elortza, Felix, Lu, Shelly C, Mato, Jose M, Falcon-Perez, Juan M

“…Exosomes represent a discrete population of vesicles that are secreted from various cell types to the extracellular media. Their protein and lipid composition…”
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Metabolic subtypes of patients with NAFLD exhibit distinctive cardiovascular risk profiles by Martínez‐Arranz, Ibon, Bruzzone, Chiara, Noureddin, Mazen, Gil‐Redondo, Ruben, Mincholé, Itziar, Bizkarguenaga, Maider, Arretxe, Enara, Iruarrizaga‐Lejarreta, Marta, Fernández‐Ramos, David, Lopitz‐Otsoa, Fernando, Mayo, Rebeca, Embade, Nieves, Newberry, Elizabeth, Mittendorf, Bettina, Izquierdo‐Sánchez, Laura, Smid, Vaclav, Arnold, Jorge, Iruzubieta, Paula, Pérez Castaño, Ylenia, Krawczyk, Marcin, Marigorta, Urko M., Morrison, Martine C., Kleemann, Robert, Martín‐Duce, Antonio, Hayardeny, Liat, Vitek, Libor, Bruha, Radan, Aller de la Fuente, Rocío, Crespo, Javier, Romero‐Gomez, Manuel, Banales, Jesus M, Arrese, Marco, Cusi, Kenneth, Bugianesi, Elisabetta, Klein, Samuel, Lu, Shelly C., Anstee, Quentin M., Millet, Oscar, Davidson, Nicholas O., Alonso, Cristina, Mato, José M.

“…Background and Aims We previously identified subsets of patients with NAFLD with different metabolic phenotypes. Here we align metabolomic signatures with…”
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The use of pharmacological chaperones in rare diseases caused by reduced protein stability by Gil‐Martínez, Jon, Bernardo‐Seisdedos, Ganeko, Mato, José M, Millet, Oscar

“…Rare diseases are most often caused by inherited genetic disorders that, after translation, will result in a protein with altered function. Decreased protein…”
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MicroRNAs regulate methionine adenosyltransferase 1A expression in hepatocellular carcinoma by Yang, Heping, Cho, Michele E, Li, Tony W H, Peng, Hui, Ko, Kwang Suk, Mato, Jose M, Lu, Shelly C

“…MicroRNAs (miRNAs) and methionine adenosyltransferase 1A (MAT1A) are dysregulated in hepatocellular carcinoma (HCC), and reduced MAT1A expression correlates…”
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Liver‐specific deletion of prohibitin 1 results in spontaneous liver injury, fibrosis, and hepatocellular carcinoma in mice by Ko, Kwang Suk, Tomasi, Maria Lauda, Iglesias‐Ara, Ainhoa, French, Barbara A., French, Samuel W., Ramani, Komal, Lozano, Juan José, Oh, Pilsoo, He, Lina, Stiles, Bangyan L, Li, Tony W.H, Yang, Heping, Martínez‐Chantar, M. Luz, Mato, José M., Lu, Shelly C.

“…Prohibitin 1 (PHB1) is a highly conserved, ubiquitously expressed protein that participates in diverse processes including mitochondrial chaperone, growth and…”
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Exploration of Human Serum Lipoprotein Supramolecular Phospholipids Using Statistical Heterospectroscopy in n -Dimensions (SHY- n ): Identification of Potential Cardiovascular Risk Biomarkers Related to SARS-CoV-2 Infection by Masuda, Reika, Lodge, Samantha, Whiley, Luke, Gray, Nicola, Lawler, Nathan, Nitschke, Philipp, Bong, Sze-How, Kimhofer, Torben, Loo, Ruey Leng, Boughton, Berin, Zeng, Annie X, Hall, Drew, Schaefer, Hartmut, Spraul, Manfred, Dwivedi, Girish, Yeap, Bu B, Diercks, Tammo, Bernardo-Seisdedos, Ganeko, Mato, José M, Lindon, John C, Holmes, Elaine, Millet, Oscar, Wist, Julien, Nicholson, Jeremy K

“…SARS-CoV-2 infection causes a significant reduction in lipoprotein-bound serum phospholipids give rise to supramolecular phospholipid composite (SPC) signals…”
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The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injury by Barbier-Torres, Lucía, Iruzubieta, Paula, Fernández-Ramos, David, Delgado, Teresa C., Taibo, Daniel, Guitiérrez-de-Juan, Virginia, Varela-Rey, Marta, Azkargorta, Mikel, Navasa, Nicolas, Fernández-Tussy, Pablo, Zubiete-Franco, Imanol, Simon, Jorge, Lopitz-Otsoa, Fernando, Lachiondo-Ortega, Sofia, Crespo, Javier, Masson, Steven, McCain, Misti Vanette, Villa, Erica, Reeves, Helen, Elortza, Felix, Lucena, Maria Isabel, Hernández-Alvarez, Maria Isabel, Zorzano, Antonio, Andrade, Raúl J., Lu, Shelly C., Mato, José M., Anguita, Juan, Rincón, Mercedes, Martínez-Chantar, María Luz

“…Acetaminophen (APAP) is the active component of many medications used to treat pain and fever worldwide. Its overuse provokes liver injury and it is the second…”
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A molecular signature for the metabolic syndrome by urine metabolomics by Bruzzone, Chiara, Gil-Redondo, Rubén, Seco, Marisa, Barragán, Rocío, de la Cruz, Laura, Cannet, Claire, Schäfer, Hartmut, Fang, Fang, Diercks, Tammo, Bizkarguenaga, Maider, González-Valle, Beatriz, Laín, Ana, Sanz-Parra, Arantza, Coltell, Oscar, de Letona, Ander López, Spraul, Manfred, Lu, Shelly C, Buguianesi, Elisabetta, Embade, Nieves, Anstee, Quentin M, Corella, Dolores, Mato, José M, Millet, Oscar

“…Metabolic syndrome (MetS) is a multimorbid long-term condition without consensual medical definition and a diagnostic based on compatible symptomatology. Here…”
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Depletion of mitochondrial methionine adenosyltransferase α1 triggers mitochondrial dysfunction in alcohol-associated liver disease by Barbier-Torres, Lucía, Murray, Ben, Yang, Jin Won, Wang, Jiaohong, Matsuda, Michitaka, Robinson, Aaron, Binek, Aleksandra, Fan, Wei, Fernández-Ramos, David, Lopitz-Otsoa, Fernando, Luque-Urbano, Maria, Millet, Oscar, Mavila, Nirmala, Peng, Hui, Ramani, Komal, Gottlieb, Roberta, Sun, Zhaoli, Liangpunsakul, Suthat, Seki, Ekihiro, Van Eyk, Jennifer E., Mato, Jose M., Lu, Shelly C.

“…MATα1 catalyzes the synthesis of S-adenosylmethionine, the principal biological methyl donor. Lower MATα1 activity and mitochondrial dysfunction occur in…”
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