Celiac disease associated antibodies in persons with latent autoimmune diabetes of adult and type 2 diabetes

Celiac disease associated antibodies in persons with latent autoimmune diabetes of adult and type 2 diabetes

Background: Celiac Disease (CD) is present in 1-16.4% of patients with type 1 diabetes mellitus. The most important serological markers of CD are anti-endomysial (EMA), anti-tissue transglutaminase (tTGA) and antigliadin antibodies (AGA). Aim/hypothesis: The objective of this work is to determine th...

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Published in:Autoimmunity (Chur, Switzerland) Vol. 40; no. 2; pp. 103 - 107
Main Authors: Cruz, Julio Cesar Sánchez, Rode, Eduardo Cabrera, Gómez, Luis Sorell, Cabrera, José A. Galvan, Ortega, Ania Hernandez, Mato, Gisela Molina, Amador, Pedro A. Perich, Puig, Manuel E. Licea, Alonso, Emma Domínguez, Díaz-Horta, Oscar
Format: Journal Article
Language:English
Published: England Informa UK Ltd 01-03-2007
Taylor & Francis
Subjects:
Adult
Aged
antigliadin antibodies
antitissue transglutaminase antibodies
Autoantibodies - immunology
Body Mass Index
Celiac disease
Celiac Disease - immunology
Diabetes Mellitus, Type 1 - immunology
Diabetes Mellitus, Type 2 - immunology
Female
Gliadin - immunology
Humans
LADA
Male
Middle Aged
Transglutaminases - immunology
type 2 diabetes
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Summary:Background: Celiac Disease (CD) is present in 1-16.4% of patients with type 1 diabetes mellitus. The most important serological markers of CD are anti-endomysial (EMA), anti-tissue transglutaminase (tTGA) and antigliadin antibodies (AGA). Aim/hypothesis: The objective of this work is to determine the frequency of tTGA and/or AGA in latent autoimmune diabetes of adult (LADA) and subjects with type 2 diabetes (T2DM), as well as to evaluate their relation with several clinical and biochemical characteristics. Subjects and Methods: Forty three subjects with LADA and 99 with T2DM were studied. The presence of AGA, tTGA was determined in the sera of these patients. The variables: sex, age, duration of diabetes, treatment, body mass index (BMI) and fasting blood glucose concentration were also recorded. Results: No differences were found in the frequency of celiac disease associated antibodies between LADA and T2DM subjects. The presence of celiac disease related antibodies was more frequent in patients with a normal or low BMI. Conclusions: Celiac disease does not seem to be related with pancreatic autoimmunity in type 2 diabetes. Celiac disease causes a decrease of body mass index in type 2 diabetes while pancreatic islet autoimmunity in this entity masks this effect.
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ISSN:0891-6934
1607-842X
DOI:10.1080/08916930601118825