Search Results - "Matmati, Samah"
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Telomerase Repairs Collapsed Replication Forks at Telomeres
Published in Cell reports (Cambridge) (10-03-2020)“…Telomeres are difficult-to-replicate sites whereby replication itself may threaten telomere integrity. We investigate, in fission yeast, telomere replication…”
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Solving the Telomere Replication Problem
Published in Genes (31-01-2017)“…Telomeres are complex nucleoprotein structures that protect the extremities of linear chromosomes. Telomere replication is a major challenge because many…”
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Eroded telomeres are rearranged in quiescent fission yeast cells through duplications of subtelomeric sequences
Published in Nature communications (22-11-2017)“…While the mechanisms of telomere maintenance has been investigated in dividing cells, little is known about the stability of telomeres in quiescent cells and…”
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Stn1-Ten1 and Taz1 independently promote replication of subtelomeric fragile sequences in fission yeast
Published in Cell reports (Cambridge) (27-06-2023)“…Efficient replication of terminal DNA is crucial to maintain telomere stability. In fission yeast, Taz1 and the Stn1-Ten1 (ST) complex play prominent roles in…”
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Ssu72 phosphatase is a conserved telomere replication terminator
Published in The EMBO journal (01-04-2019)“…Telomeres, the protective ends of eukaryotic chromosomes, are replicated through concerted actions of conventional DNA polymerases and elongated by telomerase,…”
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The fission yeast Stn1-Ten1 complex limits telomerase activity via its SUMO-interacting motif and promotes telomeres replication
Published in Science advances (16-05-2018)“…Mammalian CST (CTC1-STN1-TEN1) complex fulfills numerous functions including rescue of the stalled replication forks and termination of telomerase action. In…”
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Pot1 promotes telomere DNA replication via the Stn1-Ten1 complex in fission yeast
Published in Nucleic acids research (11-12-2023)“…Abstract Telomeres are nucleoprotein complexes that protect the chromosome-ends from eliciting DNA repair while ensuring their complete duplication. Pot1 is a…”
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