Search Results - "Matkarimov, Bakhyt T."

XPC deficiency increases risk of hematologic malignancies through mutator phenotype and characteristic mutational signature by Yurchenko, Andrey A., Padioleau, Ismael, Matkarimov, Bakhyt T., Soulier, Jean, Sarasin, Alain, Nikolaev, Sergey

“…Recent studies demonstrated a dramatically increased risk of leukemia in patients with a rare genetic disorder, Xeroderma Pigmentosum group C (XP-C),…”
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Chargaff's second parity rule lies at the origin of additive genetic interactions in quantitative traits to make omnigenic selection possible by Matkarimov, Bakhyt T, Saparbaev, Murat K

“…Francis Crick's central dogma provides a residue-by-residue mechanistic explanation of the flow of genetic information in living systems. However, this…”
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The Human DNA glycosylases NEIL1 and NEIL3 Excise Psoralen-Induced DNA-DNA Cross-Links in a Four-Stranded DNA Structure by Martin, Peter R., Couvé, Sophie, Zutterling, Caroline, Albelazi, Mustafa S., Groisman, Regina, Matkarimov, Bakhyt T., Parsons, Jason L., Elder, Rhoderick H., Saparbaev, Murat K.

“…Interstrand cross-links (ICLs) are highly cytotoxic DNA lesions that block DNA replication and transcription by preventing strand separation. Previously, we…”
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DNA-Histone Cross-Links: Formation and Repair by Pachva, Manideep C, Kisselev, Alexei F, Matkarimov, Bakhyt T, Saparbaev, Murat, Groisman, Regina

“…The nucleosome is a stretch of DNA wrapped around a histone octamer. Electrostatic interactions and hydrogen bonds between histones and DNA are vital for the…”
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Evolutionary Origins of DNA Repair Pathways: Role of Oxygen Catastrophe in the Emergence of DNA Glycosylases by Prorok, Paulina, Grin, Inga R., Matkarimov, Bakhyt T., Ishchenko, Alexander A., Laval, Jacques, Zharkov, Dmitry O., Saparbaev, Murat

“…It was proposed that the last universal common ancestor (LUCA) evolved under high temperatures in an oxygen-free environment, similar to those found in…”
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Is there an advantageous arrangement of aromatic residues in proteins? Statistical analysis of aromatic interactions in globular proteins by Lobanov, Mikhail Yu, Pereyaslavets, Leonid B., Likhachev, Ilya V., Matkarimov, Bakhyt T., Galzitskaya, Oxana V.

“…[Display omitted] The aim of this study was to evaluate the favorability of different conformations of aromatic residues in proteins by analysing the…”
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Aberrant repair initiated by the adenine-DNA glycosylase does not play a role in UV-induced mutagenesis in Escherichia coli by Zutterling, Caroline, Mursalimov, Aibek, Talhaoui, Ibtissam, Koshenov, Zhanat, Akishev, Zhiger, Bissenbaev, Amangeldy K, Mazon, Gerard, Geacintov, Nicolas E, Gasparutto, Didier, Groisman, Regina, Zharkov, Dmitry O, Matkarimov, Bakhyt T, Saparbaev, Murat

“…DNA repair is essential to counteract damage to DNA induced by endo- and exogenous factors, to maintain genome stability. However, challenges to the faithful…”
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Characterization of DNA ADP-ribosyltransferase activities of PARP2 and PARP3: new insights into DNA ADP-ribosylation by Zarkovic, Gabriella, Belousova, Ekaterina A, Talhaoui, Ibtissam, Saint-Pierre, Christine, Kutuzov, Mikhail M, Matkarimov, Bakhyt T, Biard, Denis, Gasparutto, Didier, Lavrik, Olga I, Ishchenko, Alexander A

“…Abstract Poly(ADP-ribose) polymerases (PARPs) act as DNA break sensors and catalyze the synthesis of polymers of ADP-ribose (PAR) covalently attached to…”
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Insight into DNA substrate specificity of PARP1-catalysed DNA poly(ADP-ribosyl)ation by Matta, Elie, Kiribayeva, Assel, Khassenov, Bekbolat, Matkarimov, Bakhyt T., Ishchenko, Alexander A.

“…DNA-dependent poly(ADP-ribose) polymerases (PARPs) PARP1, PARP2 and PARP3 act as DNA break sensors signalling DNA damage. Upon detecting DNA damage, these…”
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Poly(ADP-ribose) polymerases covalently modify strand break termini in DNA fragments in vitro by Talhaoui, Ibtissam, Lebedeva, Natalia A, Zarkovic, Gabriella, Saint-Pierre, Christine, Kutuzov, Mikhail M, Sukhanova, Maria V, Matkarimov, Bakhyt T, Gasparutto, Didier, Saparbaev, Murat K, Lavrik, Olga I, Ishchenko, Alexander A

“…Poly(ADP-ribose) polymerases (PARPs/ARTDs) use nicotinamide adenine dinucleotide (NAD ) to catalyse the synthesis of a long branched poly(ADP-ribose) polymer…”
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Enhanced thermal stability enables human mismatch-specific thymine-DNA glycosylase to catalyse futile DNA repair by Manapkyzy, Diana, Joldybayeva, Botagoz, Ishchenko, Alexander A, Matkarimov, Bakhyt T, Zharkov, Dmitry O, Taipakova, Sabira, Saparbaev, Murat K

“…Human thymine-DNA glycosylase (TDG) excises T mispaired with G in a CpG context to initiate the base excision repair (BER) pathway. TDG is also involved in…”
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Aberrant base excision repair pathway of oxidatively damaged DNA: Implications for degenerative diseases by Talhaoui, Ibtissam, Matkarimov, Bakhyt T., Tchenio, Thierry, Zharkov, Dmitry O., Saparbaev, Murat K.

“…In cellular organisms composition of DNA is constrained to only four nucleobases A, G, T and C, except for minor DNA base modifications such as methylation…”
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Reading Targeted DNA Damage in the Active Demethylation Pathway: Role of Accessory Domains of Eukaryotic AP Endonucleases and Thymine-DNA Glycosylases by Popov, Alexander V., Grin, Inga R., Dvornikova, Antonina P., Matkarimov, Bakhyt T., Groisman, Regina, Saparbaev, Murat, Zharkov, Dmitry O.

“…Base excision DNA repair (BER) is an important process used by all living organisms to remove nonbulky lesions from DNA. BER is usually initiated by DNA…”
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Mechanism of stimulation of DNA binding of the transcription factors by human apurinic/apyrimidinic endonuclease 1, APE1 by Bazlekowa-Karaban, Milena, Prorok, Paulina, Baconnais, Sonia, Taipakova, Sabira, Akishev, Zhiger, Zembrzuska, Dominika, Popov, Alexander V., Endutkin, Anton V., Groisman, Regina, Ishchenko, Alexander A., Matkarimov, Bakhyt T., Bissenbaev, Amangeldy, Le Cam, Eric, Zharkov, Dmitry O., Tudek, Barbara, Saparbaev, Murat

“…[Display omitted] •APE1 forms a stable complex with ssDNA longer than 15 mer;•APE1-catalyzed repair and TF-stimulating activities depend on the structure of…”
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Mechanistic insight into the role of Poly(ADP-ribosyl)ation in DNA topology modulation and response to DNA damage by Matkarimov, Bakhyt T, Zharkov, Dmitry O, Saparbaev, Murat K

“…Abstract Genotoxic stress generates single- and double-strand DNA breaks either through direct damage by reactive oxygen species or as intermediates of DNA…”
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The role of the N-terminal domain of human apurinic/apyrimidinic endonuclease 1, APE1, in DNA glycosylase stimulation by Kladova, Olga A., Bazlekowa-Karaban, Milena, Baconnais, Sonia, Piétrement, Olivier, Ishchenko, Alexander A., Matkarimov, Bakhyt T., Iakovlev, Danila A., Vasenko, Andrey, Fedorova, Olga S., Le Cam, Eric, Tudek, Barbara, Kuznetsov, Nikita A., Saparbaev, Murat

“…[Display omitted] •The redox domain of APE1 is required for DNA glycosylase activity stimulation.•APE1 stabilizes enzyme–substrate and stimulates disruption of…”
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Oxidatively Generated Guanine(C8)-Thymine(N3) Intrastrand Cross-links in Double-stranded DNA Are Repaired by Base Excision Repair Pathways by Talhaoui, Ibtissam, Shafirovich, Vladimir, Liu, Zhi, Saint-Pierre, Christine, Akishev, Zhiger, Matkarimov, Bakhyt T., Gasparutto, Didier, Geacintov, Nicholas E., Saparbaev, Murat

“…Oxidatively generated guanine radical cations in DNA can undergo various nucleophilic reactions including the formation of C8-guanine cross-links with adjacent…”
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Structural comparison of AP endonucleases from the exonuclease III family reveals new amino acid residues in human AP endonuclease 1 that are involved in incision of damaged DNA by Redrejo-Rodríguez, Modesto, Vigouroux, Armelle, Mursalimov, Aibek, Grin, Inga, Alili, Doria, Koshenov, Zhanat, Akishev, Zhiger, Maksimenko, Andrei, Bissenbaev, Amangeldy K., Matkarimov, Bakhyt T., Saparbaev, Murat, Ishchenko, Alexander A., Moréra, Solange

“…Oxidatively damaged DNA bases are substrates for two overlapping repair pathways: DNA glycosylase-initiated base excision repair (BER) and…”
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Ile351, Leu355 and Ile461 residues are essential for catalytic activity of bovine cytochrome P450scc (CYP11A1) by Glyakina, Anna V., Strizhov, Nicolai I., Karpov, Mikhail V., Dovidchenko, Nikita V., Matkarimov, Bakhyt T., Isaeva, Ludmila V., Efimova, Vera S., Rubtsov, Mikhail A., Novikova, Ludmila A., Donova, Marina V., Galzitskaya, Oxana V.

“…[Display omitted] •The considered cytochromes P450 have low homology, but quite similar space structures.•These proteins are depleted in Ala and Gly and…”
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