Search Results - "Matis, L A"

Myocardial infarction and apoptosis after myocardial ischemia and reperfusion : Role of the terminal complement components and inhibition by anti-C5 therapy by VAKEVA, A. P, AGAH, A, ROLLINS, S. A, MATIS, L. A, LAN LI, STAHL, G. L

“…Myocardial ischemia and reperfusion (MI/R)-induced tissue injury involves necrosis and apoptosis. However, the precise contribution of apoptosis to cell death,…”
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Effect of neutralizing antibodies to IL-10 and C5 on the renal damage caused by a pathogenic human anti-dsDNA antibody by Ravirajan, C. T., Wang, Y., Matis, L. A., Papadaki, L., Griffiths, M. H., Latchman, D. S., Isenberg, D. A.

“…Objectives. There is considerable evidence suggesting that anti-double-stranded deoxyribonucleic acid (anti-dsDNA) antibodies are involved in the pathogenesis…”
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Amelioration of lupus-like autoimmune disease in NZB/WF1 mice after treatment with a blocking monoclonal antibody specific for complement component C5 by Wang, Y, Hu, Q, Madri, J A, Rollins, S A, Chodera, A, Matis, L A

“…New Zealand black x New Zealand white (NZB/W) F1 mice spontaneously develop an autoimmune syndrome with notable similarities to human systemic lupus…”
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Anti-C5 Monoclonal Antibody Therapy Prevents Collagen-Induced Arthritis and Ameliorates Established Disease by Wang, Yi, Rollins, Scott A., Madri, Joseph A., Matis, Louis A.

“…Activated components of the complement system are potent mediators of inflammation that may play an important role in numerous disease states. For example,…”
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Inducible Costimulator Regulates Th2-Mediated Inflammation, but Not Th2 Differentiation, in a Model of Allergic Airway Disease by Tesciuba, Amanda G, Subudhi, Sumit, Rother, Russell P, Faas, Susan J, Frantz, Aric M, Elliot, David, Weinstock, Joel, Matis, Louis A, Bluestone, Jeffrey A, Sperling, Anne I

“…A novel costimulatory molecule expressed on activated T cells, inducible costimulator (ICOS), and its ligand, B7-related protein-1 (B7RP-1), were recently…”
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Expression of a functional human complement inhibitor in a transgenic pig as a model for the prevention of xenogeneic hyperacute organ rejection by Fodor, W L, Williams, B L, Matis, L A, Madri, J A, Rollins, S A, Knight, J W, Velander, W, Squinto, S P

“…The serious shortage of human organs available for transplantation has engendered a heightened interest in the use of animal organs (xenografts) for…”
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Peptide-major histocompatibility complex class II complexes with mixed agonist/antagonist properties provide evidence for ligand-related differences in T cell receptor-dependent intracellular signaling by RACIOPPI, L, RONCHESE, F, MATIS, L. A, GERMAIN, R. N

“…Clonal activation of CD4+ and CD8+ T lymphocytes depends on binding of peptide-major histocompatibility complex (MHC) molecule complexes by their alpha/beta…”
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The Molecular Basis of T-Cell Specificity by Matis, L A

“…Studies of TCR expression in antigen-specific immune responses have provided a large body of information correlating the primary structure of the TCR with…”
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Blockade of C5a and C5b-9 generation inhibits leukocyte and platelet activation during extracorporeal circulation by Rinder, C S, Rinder, H M, Smith, B R, Fitch, J C, Smith, M J, Tracey, J B, Matis, L A, Squinto, S P, Rollins, S A

“…Complement activation contributes to the systemic inflammatory response induced by cardiopulmonary bypass. At the cellular level, cardiopulmonary bypass…”
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Complement inhibition with an anti-C5 monoclonal antibody prevents hyperacute rejection in a xenograft heart transplantation model by HAO WANG, ROLLINS, S. A, ZUHUA GAO, GARCIA, B, ZHENG ZHANG, JINGJING XING, LAN LI, KELLERSMANN, R, MATIS, L. A, ZHONG, R

“…The present study was undertaken to determine whether anti-complement 5 (C5) monoclonal antibodies (mAb) prevent hyperacute rejection (HAR) in a…”
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Magnitude of Response of Histocompatibility-Restricted T-Cell Clones is a Function of the Product of the Concentrations of Antigen and Ia Molecules by Matis, Louis A., Glimcher, Laurie H., Paul, William E., Schwartz, Ronald H.

“…The activation of specific T-cell clones by antigens is dependent upon the corecognition of restriction elements expressed on antigen-presenting cells (APC)…”
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Evidence that activation of human T cells by porcine endothelium involves direct recognition of porcine SLA and costimulation by porcine ligands for LFA-1 and CD2 by Rollins, S A, Kennedy, S P, Chodera, A J, Elliott, E A, Zavoico, G B, Matis, L A

“…In this study we present a comprehensive evaluation of the molecular interactions between human T cells and porcine aortic endothelial cells (PAEC) that…”
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Complement inhibition with an anti-C5 monoclonal antibody prevents acute cardiac tissue injury in an ex vivo model of pig-to-human xenotransplantation by Kroshus, T J, Rollins, S A, Dalmasso, A P, Elliott, E A, Matis, L A, Squinto, S P, Bolman, 3rd, R M

“…Prevention of hyperacute xenograft rejection in the pig-to-primate combination has been accomplished by removal of natural antibodies, complement depletion…”
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Serial MR Imaging of Experimental Autoimmune Encephalomyelitis Induced by Human White Matter or by Chimeric Myelin-Basic and Proteolipid Protein in the Common Marmoset by Jordan, E. Kay, McFarland, Hugh I, Lewis, Bobbi K, Tresser, Nancy, Gates, Michael A, Johnson, Michele, Lenardo, Michael, Matis, Louis A, McFarland, Henry F, Frank, Joseph A

“…Experimental autoimmune encephalomyelitis (EAE) in the marmoset was monitored by serial MR imaging to determine correlates to the natural-history MR studies in…”
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Complement-specific antibodies: Designing novel anti-inflammatories by Matis, Louis A, Rollins, Scott A

“…The immunoglobulin variable gene repertoire generates enormous diversity through both combinatorial and somatic mutational mechanisms. Consequently, it has the…”
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Role of porcine P-selectin in complement-dependent adhesion of human leukocytes to porcine endothelial cells by ROLLINS, S. A, JOHNSON, K. K, LAN LI, BIRKS, C, MATIS, L. A, ROTHER, R. P

“…Rapid leukocyte adherence to donor organ vasculature is a hallmark of hyperacute xenograft rejection. However, the molecular interactions required for…”
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Selection of Amino Acid Sequences in the Beta Chain of the T Cell Antigen Receptor by Hedrick, Stephen M., Engel, Isaac, McElligott, David L., Fink, Pamela J., Hsu, Mei-Ling, Hansburg, Daniel, Matis, Louis A.

“…The induction of an immune response in mammals is initiated by specifically reactive T lymphocytes. The specificity of the reaction is mediated by a complex…”
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Effective Antigen-Specific Immunotherapy in the Marmoset Model of Multiple Sclerosis by McFarland, Hugh I, Lobito, Adrian A, Johnson, Michele M, Palardy, Gregory R, Yee, Christina S. K, Jordan, E. Kay, Frank, Joseph A, Tresser, Nancy, Genain, Claude P, Mueller, John P, Matis, Louis A, Lenardo, Michael J

“…Mature T cells initially respond to Ag by activation and expansion, but high and repeated doses of Ag cause programmed cell death and can suppress T…”
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The Role of Fas in Autoimmune Diabetes by Chervonsky, Alexander V, Wang, Yi, Wong, F.Susan, Visintin, Irene, Flavell, Richard A, Janeway, Charles A, Matis, Louis A

“…Immunologically privileged sites express Fas ligand (FasL), which protects them from attack by activated T cells that express Fas and die upon contact with…”
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Ntk: A Csk-Related Protein-Tyrosine Kinase Expressed in Brain and T Lymphocytes by Lionel M. L. Chow, Jarvis, Christopher, Hu, Qile, Nye, Steven H., Gervais, Francois G., Veillette, Andre, Matis, Louis A.

“…The activity of Src-related protein-tyrosine kinases is repressed by the phosphorylation of a conserved carboxyl-terminal tyrosine by another cytoplasmic…”
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