Search Results - "Matilla, Lara"

Myocardial Injury After Ischemia/Reperfusion Is Attenuated By Pharmacological Galectin-3 Inhibition by Ibarrola, Jaime, Matilla, Lara, Martínez-Martínez, Ernesto, Gueret, Alexandre, Fernández-Celis, Amaya, Henry, Jean-Paul, Nicol, Lionel, Jaisser, Frederic, Mulder, Paul, Ouvrard-Pascaud, Antoine, López-Andrés, Natalia

“…Although optimal therapy for myocardial infarction includes reperfusion to restore blood flow to the ischemic region, ischemia/reperfusion (IR) also initiates…”
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Targeting Fatty Acid-Binding Protein 4 Improves Pathologic Features of Aortic Stenosis by Garaikoetxea, Mattie, Martín-Núñez, Ernesto, Navarro, Adela, Matilla, Lara, Fernández-Celis, Amaya, Arrieta, Vanessa, García-Peña, Amaia, Gainza, Alicia, Álvarez, Virginia, Sádaba, Rafael, Jover, Eva, López-Andrés, Natalia

“…Aortic stenosis (AS) is a fibrocalcific disease of the aortic valves (AVs). Sex-differences in AS pathophysiology have recently been described. High levels of…”
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Beneficial Effects of Mineralocorticoid Receptor Antagonism on Myocardial Fibrosis in an Experimental Model of the Myxomatous Degeneration of the Mitral Valve by Ibarrola, Jaime, Garaikoetxea, Mattie, Garcia-Peña, Amaia, Matilla, Lara, Jover, Eva, Bonnard, Benjamin, Cuesta, Maria, Fernández-Celis, Amaya, Jaisser, Frederic, López-Andrés, Natalia

“…Mitral valve prolapse (MVP) patients develop myocardial fibrosis that is not solely explained by volume overload, but the pathophysiology has not been defined…”
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Influence of diabetes mellitus on the pathological profile of aortic stenosis: a sex-based approach by Martín-Núñez, Ernesto, Goñi-Olóriz, Miriam, Matilla, Lara, Garaikoetxea, Mattie, Mourino-Alvarez, Laura, Navarro, Adela, Fernández-Celis, Amaya, Tamayo, Ibai, Gainza, Alicia, Álvarez, Virginia, Sádaba, Rafael, Barderas, María G., Jover, Eva, López-Andrés, Natalia

“…Abstract Background Diabetes mellitus (DM) accelerates the progression of aortic stenosis (AS), but how their underlying molecular mechanisms interact is not…”
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Activation of the Interleukin-33/ST2 Pathway Exerts Deleterious Effects in Myxomatous Mitral Valve Disease by Garcia-Pena, Amaia, Ibarrola, Jaime, Navarro, Adela, Sadaba, Alba, Tiraplegui, Carolina, Garaikoetxea, Mattie, Arrieta, Vanessa, Matilla, Lara, Fernández-Celis, Amaya, Sadaba, Rafael, Alvarez, Virginia, Gainza, Alicia, Jover, Eva, López-Andrés, Natalia

“…Mitral valve disease (MVD) is a frequent cause of heart failure and death worldwide, but its etiopathogenesis is not fully understood. Interleukin (IL)-33…”
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Sex-Differences in Aortic Stenosis: Mechanistic Insights and Clinical Implications by Matilla, Lara, Garaikoetxea, Mattie, Arrieta, Vanessa, García-Peña, Amaia, Fernández-Celis, Amaya, Navarro, Adela, Gainza, Alicia, Álvarez, Virginia, Sádaba, Rafael, Jover, Eva, López-Andrés, Natalia

“…We aim to analyse sex-specific differences in aortic valves (AVs) and valve interstitial cells (VICs) from aortic stenosis (AS) patients. 238 patients with…”
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Beneficial Effects of Mineralocorticoid Receptor Pathway Blockade against Endothelial Inflammation Induced by SARS-CoV-2 Spike Protein by Jover, Eva, Matilla, Lara, Garaikoetxea, Mattie, Fernández-Celis, Amaya, Muntendam, Pieter, Jaisser, Frédéric, Rossignol, Patrick, López-Andrés, Natalia

“…Background: Vascular endothelial cells activation and dysfunction mediate inflammation and abnormal coagulation in COVID-19 patients. Mineralocorticoid…”
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Estrogen Receptor-Alpha (ESR1) Governs the Lower Female Reproductive Tract Vulnerability to Candida albicans by Salinas-Muñoz, Laura, Campos-Fernández, Raúl, Mercader, Enrique, Olivera-Valle, Irene, Fernández-Pacheco, Carlota, Matilla, Lara, García-Bordas, Julio, Brazil, Jennifer C, Parkos, Charles A, Asensio, Fernando, Muñoz-Fernández, Maria A, Hidalgo, Andrés, Sánchez-Mateos, Paloma, Samaniego, Rafael, Relloso, Miguel

“…Estradiol-based therapies predispose women to vaginal infections. Moreover, it has long been known that neutrophils are absent from the vaginal lumen during…”
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Sex-dependent expression of neutrophil gelatinase-associated lipocalin in aortic stenosis by Jover, Eva, Matilla, Lara, Martín-Núñez, Ernesto, Garaikoetxea, Mattie, Navarro, Adela, Fernández-Celis, Amaya, Gainza, Alicia, Arrieta, Vanessa, García-Peña, Amaia, Álvarez, Virginia, Sádaba, Rafael, Jaisser, Frederic, López-Andrés, Natalia

“…Accumulating evidence suggest the existence of sex-related differences in the pathogenesis of aortic stenosis (AS) with inflammation, oxidative stress,…”
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Characterization of the sex-specific pattern of angiogenesis and lymphangiogenesis in aortic stenosis by Matilla, Lara, Martín-Núñez, Ernesto, Garaikoetxea, Mattie, Navarro, Adela, Vico, Julieta Anabela, Arrieta, Vanessa, García-Peña, Amaia, Fernández-Celis, Amaya, Gainza, Alicia, Álvarez, Virginia, Sádaba, Rafael, López-Andrés, Natalia, Jover, Eva

“…Objective We aim to analyze sex-related differences in angiogenesis and lymphangiogenesis in aortic valves (AVs) and valve interstitial cells (VICs) from…”
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Sex-specific role of galectin-3 in aortic stenosis by Matilla, Lara, Martín-Núéez, Ernesto, Garaikoetxea, Mattie, Navarro, Adela, Tamayo, Ibai, Fernández-Celis, Amaya, Gainza, Alicia, Fernández-Irigoyen, Joaquín, Santamaría, Enrique, Muntendam, Pieter, Ãlvarez, Virginia, Sádaba, Rafael, Jover, Eva, López-Andrés, Natalia

“…Abstract Background Aortic stenosis (AS) is characterized by inflammation, fibrosis, osteogenesis and angiogenesis. Men and women develop these mechanisms…”
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Soluble St2 Induces Cardiac Fibroblast Activation and Collagen Synthesis via Neuropilin-1 by Matilla, Lara, Arrieta, Vanessa, Jover, Eva, Garcia-Peña, Amaia, Martinez-Martinez, Ernesto, Sadaba, Rafael, Alvarez, Virginia, Navarro, Adela, Fernandez-Celis, Amaya, Gainza, Alicia, Santamaria, Enrique, Fernandez-Irigoyen, Joaquín, Rossignol, Patrick, Zannad, Faiez, Lopez-Andres, Natalia

“…Circulating levels of soluble interleukin 1 receptor-like 1 (sST2) are increased in heart failure and associated with poor outcome, likely because of the…”
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A Role for MMP-10 (Matrix Metalloproteinase-10) in Calcific Aortic Valve Stenosis by Matilla, Lara, Roncal, Carmen, Ibarrola, Jaime, Arrieta, Vanessa, García-Peña, Amaia, Fernández-Celis, Amaya, Navarro, Adela, Álvarez, Virginia, Gainza, Alicia, Orbe, Josune, Cachofeiro, Victoria, Zalba, Guillermo, Sádaba, Rafael, Rodríguez, José A., López-Andrés, Natalia

“…OBJECTIVE:Aortic valve (AV) calcification plays an important role in the progression of aortic stenosis (AS). MMP-10 (matrix metalloproteinase-10 or…”
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Sex-Related Signaling of Aldosterone/Mineralocorticoid Receptor Pathway in Calcific Aortic Stenosis by Matilla, Lara, Jover, Eva, Garaikoetxea, Mattie, Martín-Nuñez, Ernesto, Arrieta, Vanessa, García-Peña, Amaia, Navarro, Adela, Fernández-Celis, Amaya, Gainza, Alicia, Álvarez, Virginia, Álvarez de la Rosa, Diego, Sádaba, Rafael, Jaisser, Frederic, López-Andrés, Natalia

“…There are sex differences in the pathophysiology of aortic valve (AV) calcification in patients with aortic stenosis, although the molecular and cellular…”
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Soluble ST2 as a New Oxidative Stress and Inflammation Marker in Metabolic Syndrome by Roy, Ignacio, Jover, Eva, Matilla, Lara, Alvarez, Virginia, Fernández-Celis, Amaya, Beunza, Maite, Escribano, Elena, Gainza, Alicia, Sádaba, Rafael, López-Andrés, Natalia

“…Metabolic syndrome (MS) is a complex and prevalent disorder. Oxidative stress and inflammation might contribute to the progression of MS. Soluble ST2 (sST2) is…”
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Neuropilin-1 sex-dependently modulates inflammatory, angiogenic and osteogenic phenotypes in the calcifying valve interstitial cell by Matilla, Lara, Martín-Núñez, Ernesto, Navarro, Adela, Garaikoetxea, Mattie, Fernández-Celis, Amaya, Goñi-Olóriz, Miriam, Gainza, Alicia, Fernández-Irigoyen, Joaquín, Santamaría, Enrique, Tamayo, Ibai, Álvarez, Virginia, Sádaba, Rafael, Jover, Eva, López-Andrés, Natalia

“…[Display omitted] The pathological mechanisms underlying the sex-dependent presentation of calcific aortic stenosis (AS) remain poorly understood. We aim to…”
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Sex-Related Signaling of Aldosterone/Mineralocorticoid Receptor Pathway in Calcific Aortic Stenosis by Matilla, Lara, Jover, Eva, Garaikoetxea, Mattie, Martín-Nuñez, Ernesto, Arrieta, Vanessa, García-Peña, Amaia, Navarro, Adela, Fernández-Celis, Amaya, Gainza, Alicia, Álvarez, Virginia, de la Rosa, Diego Álvarez, Sádaba, Rafael, Jaisser, Frederic, López-Andrés, Natalia

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A New Role for the Aldosterone/Mineralocorticoid Receptor Pathway in the Development of Mitral Valve Prolapse by Ibarrola, Jaime, Garcia-Peña, Amaia, Matilla, Lara, Bonnard, Benjamin, Sádaba, Rafael, Arrieta, Vanessa, Alvarez, Virginia, Fernández-Celis, Amaya, Gainza, Alicia, Navarro, Adela, Alvarez de la Rosa, Diego, Rossignol, Patrick, Jaisser, Frederic, López-Andrés, Natalia

“…Mitral valve prolapse (MVP) is one of the most common valvular disorders. However, the molecular and cellular mechanisms involved in fibromyxomatous changes in…”
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Soluble ST2 promotes oxidative stress and inflammation in cardiac fibroblasts: an in vitro and in vivo study in aortic stenosis by Matilla, Lara, Ibarrola, Jaime, Arrieta, Vanessa, Garcia-Peña, Amaia, Martinez-Martinez, Ernesto, Sádaba, Rafael, Alvarez, Virginia, Navarro, Adela, Fernández-Celis, Amaya, Gainza, Alicia, Santamaría, Enrique, Fernández-Irigoyen, Joaquín, Bayes-Genis, Antoni, Rossignol, Patrick, López-Andrés, Natalia

“…Soluble ST2 (interleukin 1 receptor-like 1) (sST2) is involved in inflammatory diseases and increased in heart failure (HF). We herein investigated sST2…”
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Sex‐dependent expression of galectin‐1, a cardioprotective β‐galactoside‐binding lectin, in human calcific aortic stenosis by Jover, Eva, Martín‐Núñez, Ernesto, Garaikoetxea, Mattie, Matilla, Lara, Blanco‐Colio, Luis M., Pérez‐Sáez, Juan M., Navarro, Adela, Fernández‐Celis, Amaya, Gainza, Alicia, Álvarez, Virginia, Sádaba, Rafael, Tamayo, Ibai, Rabinovich, Gabriel A., Martín‐Ventura, José L., López‐Andrés, Natalia

“…We aimed to analyze sex‐related differences in galectin‐1 (Gal‐1), a β‐galactoside‐binding lectin, in aortic stenosis (AS) and its association with the…”
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