Search Results - "Matikonda, Siddharth S."

Structure–Activity Relationships of Antibody-Drug Conjugates: A Systematic Review of Chemistry on the Trastuzumab Scaffold by Matikonda, Siddharth S., McLaughlin, Ryan, Shrestha, Pradeep, Lipshultz, Carol, Schnermann, Martin J.

“…Antibody-drug conjugates (ADCs) are a rapidly growing class of cancer therapeutics that seek to overcome the low therapeutic index of conventional cytotoxic…”
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Cyanine Phototruncation Enables Spatiotemporal Cell Labeling by Fukushima, Hiroshi, Matikonda, Siddharth S., Usama, Syed Muhammad, Furusawa, Aki, Kato, Takuya, Štacková, Lenka, Klán, Petr, Kobayashi, Hisataka, Schnermann, Martin J.

“…Photoconvertible tracking strategies assess the dynamic migration of cell populations. Here we develop phototruncation-assisted cell tracking (PACT) and apply…”
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Hypoxia Responsive Drug Delivery Systems in Tumor Therapy by Alimoradi, Houman, Matikonda, Siddharth S, Gamble, Allan B, Giles, Gregory I, Greish, Khaled

“…Hypoxia is a common characteristic of solid tumors. It is mainly determined by low levels of oxygen resulting from imperfect vascular networks supplying most…”
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Bioorthogonal prodrug activation driven by a strain-promoted 1,3-dipolar cycloaddition by Matikonda, Siddharth S, Orsi, Douglas L, Staudacher, Verena, Jenkins, Imogen A, Fiedler, Franziska, Chen, Jiayi, Gamble, Allan B

“…Due to the formation of hydrolysis-susceptible adducts, the 1,3-dipolar cycloaddition between an azide and strained -cyclooctene (TCO) has been disregarded in…”
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Preparation of Fluoroalkenes via the Shapiro Reaction: Direct Access to Fluorinated Peptidomimetics by Yang, Ming-Hsiu, Matikonda, Siddharth S, Altman, Ryan A

“…Fluoroalkenes represent a useful class of peptidomimetics with distinct biophysical properties. Current preparations of this functional group commonly provide…”
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Defining the Basis of Cyanine Phototruncation Enables a New Approach to Single-Molecule Localization Microscopy by Matikonda, Siddharth S, Helmerich, Dominic A, Meub, Mara, Beliu, Gerti, Kollmannsberger, Philip, Greer, Alexander, Sauer, Markus, Schnermann, Martin J

“…The light-promoted conversion of extensively used cyanine dyes to blue-shifted emissive products has been observed in various contexts. However, both the…”
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Photoblueing of organic dyes can cause artifacts in super-resolution microscopy by Helmerich, Dominic A., Beliu, Gerti, Matikonda, Siddharth S., Schnermann, Martin J., Sauer, Markus

“…Illumination of fluorophores can induce a loss of the ability to fluoresce, known as photobleaching. Interestingly, some fluorophores photoconvert to a…”
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Impact of Cyanine Conformational Restraint in the Near-Infrared Range by Matikonda, Siddharth S, Hammersley, Gabrielle, Kumari, Nikita, Grabenhorst, Lennart, Glembockyte, Viktorija, Tinnefeld, Philip, Ivanic, Joseph, Levitus, Marcia, Schnermann, Martin J

“…Appending conformationally restraining ring systems to the cyanine chromophore creates exceptionally bright fluorophores in the visible range. Here, we report…”
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Core remodeling leads to long wavelength fluoro-coumarins by Matikonda, Siddharth S, Ivanic, Joseph, Gomez, Miguel, Hammersley, Gabrielle, Schnermann, Martin J

“…Low molecular weight, uncharged far-red and NIR dyes would be enabling for a range of imaging applications. Rational redesign of the coumarin scaffold leads to…”
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Bluer Phototruncation: Retro-Diels–Alder of Heptamethine Cyanine to Trimethine Cyanine through an Allene Hydroperoxide Intermediate by Lapoot, Lloyd, Wang, Connor, Matikonda, Siddharth S., Schnermann, Martin J., Greer, Alexander

“…The photoconversion of heptamethine to pentamethine cyanines and of pentamethine to trimethine cyanines was recently reported. Here, we report mechanistic…”
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Ketone Incorporation Extends the Emission Properties of the Xanthene Scaffold Beyond 1000 nm by Daly, Harrison C., Matikonda, Siddharth S., Steffens, Helena C., Ruehle, Bastian, Resch‐Genger, Ute, Ivanic, Joseph, Schnermann, Martin J.

“…Imaging in the shortwave‐infrared region (SWIR, λ = 1000–2500 nm) has the potential to enable deep tissue imaging with high resolution. Critical to the…”
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Targetable Conformationally Restricted Cyanines Enable Photon‐Count‐Limited Applications by Eiring, Patrick, McLaughlin, Ryan, Matikonda, Siddharth S., Han, Zhongying, Grabenhorst, Lennart, Helmerich, Dominic A., Meub, Mara, Beliu, Gerti, Luciano, Michael, Bandi, Venu, Zijlstra, Niels, Shi, Zhen‐Dan, Tarasov, Sergey G., Swenson, Rolf, Tinnefeld, Philip, Glembockyte, Viktorija, Cordes, Thorben, Sauer, Markus, Schnermann, Martin J.

“…Cyanine dyes are exceptionally useful probes for a range of fluorescence‐based applications, but their photon output can be limited by trans‐to‐cis…”
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Conformationally restrained pentamethine cyanines and use in reductive single molecule localization microscopy by Matikonda, Siddharth S, Götz, Ralph, McLaughlin, Ryan, Sauer, Markus, Schnermann, Martin J

“…Pentamethine cyanines are a class of far-red fluorophores that find extensive use in single-molecule localization microscopy (SMLM), as well as a broad range…”
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Mechanistic Evaluation of Bioorthogonal Decaging with trans-Cyclooctene: The Effect of Fluorine Substituents on Aryl Azide Reactivity and Decaging from the 1,2,3-Triazoline by Matikonda, Siddharth S, Fairhall, Jessica M, Fiedler, Franziska, Sanhajariya, Suchaya, Tucker, Robert A. J, Hook, Sarah, Garden, Anna L, Gamble, Allan B

“…Bioorthogonal prodrug activation/decaging strategies need to be selective, rapid and release the drug from the masking group upon activation. The rates of the…”
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Phototruncation cell tracking with near-infrared photoimmunotherapy using heptamethine cyanine dye to visualise migratory dynamics of immune cells by Fukushima, Hiroshi, Furusawa, Aki, Takao, Seiichiro, Matikonda, Siddharth S., Kano, Makoto, Okuyama, Shuhei, Yamamoto, Hiroshi, Choyke, Peter L., Schnermann, Martin J., Kobayashi, Hisataka

“…Noninvasive in vivo cell tracking is valuable in understanding the mechanisms that enhance anti-cancer immunity. We have recently developed a new method called…”
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Synthesis and Biological Evaluation of Aurachin D Analogues as Inhibitors of Mycobacterium tuberculosis Cytochrome bd Oxidase by Lawer, Aggie, Tyler, Chelsea, Hards, Kiel, Keighley, Laura M., Cheung, Chen-Yi, Kierek, Fabian, Su, Simon, Matikonda, Siddharth S., McInnes, Tyler, Tyndall, Joel D. A., Krause, Kurt L., Cook, Gregory M., Gamble, Allan B.

“…A revised total synthesis of aurachin D (1a), an isoprenoid quinolone alkaloid that targets Mycobacterium tuberculosis (Mtb) cytochrome bd (cyt-bd) oxidase,…”
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Stability, Kinetic, and Mechanistic Investigation of 1,8-Self-Immolative Cinnamyl Ether Spacers for Controlled Release of Phenols and Generation of Resonance and Inductively Stabilized Methides by Matikonda, Siddharth S, Fairhall, Jessica M, Tyndall, Joel D. A, Hook, Sarah, Gamble, Allan B

“…Three cinnamyl ether spacers (non-methyl, α-methyl, and γ-methyl) for caging of phenols have been synthesized and are physiologically stable. When triggered,…”
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Discovery and Structure Optimization of a Series of Isatin Derivatives as Mycobacterium tuberculosis Chorismate Mutase Inhibitors by Jeankumar, Variam U., Alokam, Reshma, Sridevi, Jonnalagadda P., Suryadevara, Priyanka, Matikonda, Siddharth S., Peddi, Santosh, Sahithi, Seedarala, Alvala, Mallika, Yogeeswari, Perumal, Sriram, Dharmarajan

“…In this study, the crystal structure of the Mycobacterium tuberculosis (MTB) enzyme chorismate mutase (CM) bound to transition state analogue (PDB: 2FP2) was…”
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Targetable Conformationally Restricted Cyanines Enable Photon‐Count‐Limited Applications by Eiring, Patrick, McLaughlin, Ryan, Matikonda, Siddharth S., Han, Zhongying, Grabenhorst, Lennart, Helmerich, Dominic A., Meub, Mara, Beliu, Gerti, Luciano, Michael, Bandi, Venu, Zijlstra, Niels, Shi, Zhen‐Dan, Tarasov, Sergey G., Swenson, Rolf, Tinnefeld, Philip, Glembockyte, Viktorija, Cordes, Thorben, Sauer, Markus, Schnermann, Martin J.

“…Cyanine dyes are exceptionally useful probes for a range of fluorescence‐based applications, but their photon output can be limited by trans‐to‐cis…”
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Phototruncation cell tracking with near-infrared photoimmunotherapy using heptamethine cyanine dye to visualise migratory dynamics of immune cellsResearch in context by Hiroshi Fukushima, Aki Furusawa, Seiichiro Takao, Siddharth S. Matikonda, Makoto Kano, Shuhei Okuyama, Hiroshi Yamamoto, Peter L. Choyke, Martin J. Schnermann, Hisataka Kobayashi

“…Background: Noninvasive in vivo cell tracking is valuable in understanding the mechanisms that enhance anti-cancer immunity. We have recently developed a new…”
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