Search Results - "Matikas, Alexios"

Genetic, transcriptional and post-translational regulation of the programmed death protein ligand 1 in cancer: biology and clinical correlations by Zerdes, Ioannis, Matikas, Alexios, Bergh, Jonas, Rassidakis, George Z., Foukakis, Theodoros

“…The programmed death protein 1 (PD-1) and its ligand (PD-L1) represent a well-characterized immune checkpoint in cancer, effectively targeted by monoclonal…”
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Response to A. Chauhan and A. Pal by Matikas, Alexios, Georgoulias, Vassilis

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Prognostic Implications of PD-L1 Expression in Breast Cancer: Systematic Review and Meta-analysis of Immunohistochemistry and Pooled Analysis of Transcriptomic Data by Matikas, Alexios, Zerdes, Ioannis, Lövrot, John, Richard, François, Sotiriou, Christos, Bergh, Jonas, Valachis, Antonios, Foukakis, Theodoros

“…Conflicting data have been reported on the prognostic value of PD-L1 protein and gene expression in breast cancer. Medline, Embase, Cochrane Library, and Web…”
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Targeting KRAS mutated non-small cell lung cancer: a history of failures and a future of hope for a diverse entity by Matikas, Alexios, Mistriotis, Dimitrios, Georgoulias, Vasilios, Kotsakis, Athanasios

“…Highlights • KRAS mutations are the most common genetic event in lung adenocarcinoma. • The prognostic and predictive value of KRAS mutations is unclear. •…”
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The interplay between eosinophils and T cells in breast cancer immunotherapy by Zerdes, Ioannis, Matikas, Alexios, Foukakis, Theodoros

“…Treatment with immune checkpoint inhibitors (ICI) has revolutionized cancer management for multiple tumor types, including breast cancer. However, not all…”
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Detection of circulating tumour cells before and following adjuvant chemotherapy and long-term prognosis of early breast cancer by Matikas, Alexios, Kotsakis, Athanasios, Apostolaki, Stella, Politaki, Helen, Perraki, Maria, Kalbakis, Kostas, Nikolaou, Michalis, Economopoulou, Panagiota, Hatzidaki, Dora, Georgoulias, Vassilis

“…Background The detection of circulating tumour cells (CTC) is prognostic for disease recurrence in early breast cancer (BC). This study aims to investigate…”
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Circulating Biomarkers in Non–Small-Cell Lung Cancer: Current Status and Future Challenges by Matikas, Alexios, Syrigos, Konstantinos N, Agelaki, Sofia

“…Abstract Despite recent advances, non–small-cell lung cancer remains a devastating disease and carries a grim prognosis. Major contributing factors include…”
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Clinically relevant gene signatures provide independent prognostic information in older breast cancer patients by Castresana-Aguirre, Miguel, Johansson, Annelie, Matikas, Alexios, Foukakis, Theodoros, Lindström, Linda S, Tobin, Nicholas P

“…The clinical utility of gene signatures in older breast cancer patients remains unclear. We aimed to determine signature prognostic capacity in this patient…”
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Systematic review and feasibility study on pre-analytical factors and genomic analyses on archival formalin-fixed paraffin-embedded breast cancer tissue by Salgkamis, Dimitrios, Sifakis, Emmanouil G., Agartz, Susanne, Wirta, Valtteri, Hartman, Johan, Bergh, Jonas, Foukakis, Theodoros, Matikas, Alexios, Zerdes, Ioannis

“…Formalin-fixed paraffin-embedded (FFPE) tissue represents a valuable source for translational cancer research. However, the widespread application of various…”
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G-CSF-induced aortitis: Two cases and review of the literature by Parodis, Ioannis, Dani, Lara, Notarnicola, Antonella, Martenhed, Git, Fernström, Pontus, Matikas, Alexios, Wiklander, Oscar P.B.

“…Febrile neutropenia is generally recognised as a complication of myelosuppressive chemotherapy. Recombinant human granulocyte colony stimulating factor (G-CSF)…”
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Chemotherapy use near the end-of-life in patients with metastatic breast cancer by Edman Kessler, Luisa, Sigfridsson, Johnny, Hatzidaki, Dora, Bergh, Jonas, Foukakis, Theodoros, Georgoulias, Vasilios, Matikas, Alexios

“…Introduction Very few data are available regarding the use of chemotherapy in patients with metastatic breast cancer (MBC) near the end-of-life, i.e., the…”
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Longitudinal molecular profiling elucidates immunometabolism dynamics in breast cancer by Wang, Kang, Zerdes, Ioannis, Johansson, Henrik J., Sarhan, Dhifaf, Sun, Yizhe, Kanellis, Dimitris C., Sifakis, Emmanouil G., Mezheyeuski, Artur, Liu, Xingrong, Loman, Niklas, Hedenfalk, Ingrid, Bergh, Jonas, Bartek, Jiri, Hatschek, Thomas, Lehtiö, Janne, Matikas, Alexios, Foukakis, Theodoros

“…Although metabolic reprogramming within tumor cells and tumor microenvironment (TME) is well described in breast cancer, little is known about how the…”
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Management of Resistance to Crizotinib in Anaplastic Lymphoma Kinase-Positive Non–Small-cell Lung Cancer by Matikas, Alexios, Kentepozidis, Nikolaos, Georgoulias, Vassilis, Kotsakis, Athanasios

“…During the past decade, the recognition of an ever-expanding list of driver oncogenic mutations in non–small-cell lung cancer has resulted in rapid therapeutic…”
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Programmed death‐ligand 1 gene expression is a prognostic marker in early breast cancer and provides additional prognostic value to 21‐gene and 70‐gene signatures in estrogen receptor‐positive disease by Zerdes, Ioannis, Sifakis, Emmanouil G., Matikas, Alexios, Chrétien, Sebastian, Tobin, Nicholas P., Hartman, Johan, Rassidakis, George Z., Bergh, Jonas, Foukakis, Theodoros

“…Gene and protein expression of programmed death‐ligand 1 (PD‐L1) are prognostic in early breast cancer (BC), but their prognostic information is inconsistent…”
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Expression patterns and prognostic implications of tumor-infiltrating lymphocytes dynamics in early breast cancer patients receiving neoadjuvant therapy: A systematic review and meta-analysis by Zhu, Yajing, Tzoras, Evangelos, Matikas, Alexios, Bergh, Jonas, Valachis, Antonios, Zerdes, Ioannis, Foukakis, Theodoros

“…High levels of tumor-infiltrating lymphocytes (TILs) are associated with better outcomes in early breast cancer and higher pathological response rates to…”
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Interplay between copy number alterations and immune profiles in the early breast cancer Scandinavian Breast Group 2004-1 randomized phase II trial: results from a feasibility study by Zerdes, Ioannis, Simonetti, Michele, Matikas, Alexios, Harbers, Luuk, Acs, Balazs, Boyaci, Ceren, Zhang, Ning, Salgkamis, Dimitrios, Agartz, Susanne, Moreno-Ruiz, Pablo, Bai, Yalai, Rimm, David L., Hartman, Johan, Mezheyeuski, Artur, Bergh, Jonas, Crosetto, Nicola, Foukakis, Theodoros

“…Emerging data indicate that genomic alterations can shape immune cell composition in early breast cancer. However, there is a need for complementary imaging…”
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Expression of insulin‐like growth factor‐1 receptor in circulating tumor cells of patients with breast cancer is associated with patient outcomes by Spiliotaki, Maria, Mavroudis, Dimitris, Kokotsaki, Maria, Vetsika, Eleni‐Kyriaki, Stoupis, Ioannis, Matikas, Alexios, Kallergi, Galatea, Georgoulias, Vassilis, Agelaki, Sofia

“…In patients with breast cancer, markers of aggressiveness such as dysregulation of the insulin‐like growth factor receptor (IGF1R) system and E‐cadherin loss…”
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Dynamic evaluation of the immune infiltrate and immune function genes as predictive markers for neoadjuvant chemotherapy in hormone receptor positive, HER2 negative breast cancer by Matikas, Alexios, Lövrot, John, Ramberg, Anna, Eriksson, Margareta, Lindsten, Therese, Lekberg, Tobias, Hedenfalk, Ingrid, Loman, Niklas, Bergh, Jonas, Hatschek, Thomas, Erlandsson, Ann, Foukakis, Theodoros

“…Gene expression (GE) signatures and Tumor Infiltrating Lymphocytes (TIL) enumeration are predictive for response to neoadjuvant chemotherapy in HR- and in…”
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PD-1 protein and gene expression as prognostic factors in early breast cancer by Matikas, Alexios, Zerdes, Ioannis, Lövrot, John, Sifakis, Emmanouil, Richard, Francois, Sotiriou, Christos, Rassidakis, Georgios, Bergh, Jonas, Valachis, Antonis, Foukakis, Theodoros

“…BackgroundThere is a paucity of data on the prognostic value of programmed cell death protein 1 (PD-1) protein and gene expression in early breast cancer (BC)…”
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Targeting the PD-1/PD-L1 axis in the treatment of lung cancer by Matikas, Alexios, Aggelaki, Sofia

“…In recent years major advances in the field of molecular profiling of non-small cell lung cancer led to the identification of targetable driver mutations and…”
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